ZMY11

Details:

UniProt Entry: Q15326
Gene: ZMYND11
Class: RING
Family: RING1
Protein length: 602
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 4ns5, 5hda

Protein Sequence ▾

>Q15326
MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV
KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR
VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG
KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI
ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ
KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG
RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS
SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD
RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV
EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR
KR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
86	151	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
94	156	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
100	148	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
102	146	Domain	Zinc finger, PHD-type	IPR001965	SM00249
103	145	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
134	263	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
151	257	Domain	Bromodomain	IPR001487	SM00297
157	268	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
184	241	Domain	Bromodomain	IPR001487	PF00439
186	238	Domain	Bromodomain	IPR001487	PS50014
278	329	Domain	PWWP domain	IPR000313	SM00293
280	331	Domain	PWWP domain	IPR000313	PS50812
282	349	Domain	PWWP domain	IPR000313	PF00855
563	598	Domain	Zinc finger, MYND-type	IPR002893	PS50865
563	598	Domain	Zinc finger, MYND-type	IPR002893	PS01360

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0034243	regulation of transcription elongation by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000120
GO:0009966	regulation of signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IMP	PMID:20732415
GO:0046329	negative regulation of JNK cascade	Biological Process	IMP	PMID:20732415
GO:0051607	defense response to virus	Biological Process	IDA	PMID:26845565
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:20732415
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0003714	transcription corepressor activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140003	histone H3K36me3 reader activity	Molecular Function	IEA	GO_REF:0000107
GO:0003690	double-stranded DNA binding	Molecular Function	IDA	PMID:24675531
GO:0005515	protein binding	Molecular Function	IPI	PMID:10734313

Enzyme–Substrate Interactions ▾

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