HERC3

Details:

UniProt Entry: Q15034
Gene: HERC3
Class: HECT
Family: HECT1
Protein length: 1050
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q15034
MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL
NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT
TEDSVAVPRL IQKLNQQTIL QVSCGNWHCL ALAADGQFFT WGKNSHGQLG LGKEFPSQAS
PQRVRSLEGI PLAQVAAGGA HSFALSLSGA VFGWGMNNAG QLGLSDEKDR ESPCHVKLLR
TQKVVYISCG EEHTAVLTKS GGVFTFGAGS CGQLGHDSMN DEVNPRRVLE LMGSEVTQIA
CGRQHTLAFV PSSGLIYAFG CGARGQLGTG HTCNVKCPSP VKGYWAAHSG QLSARADRFK
YHIVKQIFSG GDQTFVLCSK YENYSPAVDF RTMNQAHYTS LINDETIAVW RQKLSEHNNA
NTINGVVQIL SSAACWNGSF LEKKIDEHFK TSPKIPGIDL NSTRVLFEKL MNSQHSMILE
QILNSFESCL IPQLSSSPPD VEAMRIYLIL PEFPLLQDSK YYITLTIPLA MAILRLDTNP
SKVLDNWWSQ VCPKYFMKLV NLYKGAVLYL LRGRKTFLIP VLFNNYITAA LKLLEKLYKV
NLKVKHVEYD TFYIPEISNL VDIQEDYLMW FLHQAGMKAR PSIIQDTVTL CSYPFIFDAQ
AKTKMLQTDA ELQMQVAVNG ANLQNVFMLL TLEPLLARSP FLVLHVRRNN LVGDALRELS
IHSDIDLKKP LKVIFDGEEA VDAGGVTKEF FLLLLKELLN PIYGMFTYYQ DSNLLWFSDT
CFVEHNWFHL IGITCGLAIY NSTVVDLHFP LALYKKLLNV KPGLEDLKEL SPTEGRSLQE
LLDYPGEDVE ETFCLNFTIC RESYGVIEQK KLIPGGDNVT VCKDNRQEFV DAYVNYVFQI
SVHEWYTAFS SGFLKVCGGK VLELFQPSEL RAMMVGNSNY NWEELEETAI YKGDYSATHP
TVKLFWETFH EFPLEKKKKF LLFLTGSDRI PIYGMASLQI VIQSTASGEE YLPVAHTCYN
LLDLPKYSSK EILSARLTQA LDNYEGFSLA

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	122	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
1	52	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
2	380	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
36	49	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
39	49	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
52	99	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
53	102	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
55	71	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
89	99	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
103	152	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
103	155	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
103	119	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
123	419	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
142	158	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
155	205	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
156	208	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
158	172	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
208	257	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
209	260	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
247	257	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
250	268	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
260	308	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
261	312	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
309	330	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
313	377	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
314	380	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
687	1043	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
702	1048	Domain	HECT domain	IPR000569	cd00078
721	1050	Domain	HECT domain	IPR000569	SM00119
723	1050	Domain	HECT domain	IPR000569	PS50237
753	1049	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:28514442
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The E3 Ligome database, including all associated data, metadata, and documentation, is the intellectual property of Goethe University (PROXIDRUGs consortium) under the InnoDATA project.
The contents of this Database are protected under applicable copyright and database protection laws.

Prohibited Use

Use of the Database or any derivative works for commercial purposes without prior written consent from Dr. Ramachandra M. Bhaskara (Goethe University, Frankfurt and the PROXIDRUGs consortia).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Commercial purpose

The sale, lease, license, or other transfer of DATA or MODIFICATIONS to a for-profit organization. COMMERCIAL PURPOSES shall also include uses of DATA or MODIFICATIONS by any other organization, including RECIPIENT, to perform contract research to screen E3–substrate networks and compound libraries, to manufacture products for general sale or to conduct research activities that result in any sale, lease, license, or transfer of DATA or MODIFICATIONS for-profit organization.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Licensing

Unless otherwise stated, the Human E3 Ligome Database and all associated data are licensed under the Creative Commons Attribution 4.0 International License ( CC BY-NC-SA 4.0).
Contributors must agree to license their contributions under the same CC BY-NC-SA 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta, A., Cristiani, A., Nikte, S.V. et al. Multi-scale classification decodes the complexity of the human E3 ligome. Nat Commun 16, 11382 (2025).

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.