SHPRH

Details:

UniProt Entry: Q149N8
Gene: SHPRH
Class: RING
Family: RING10
Protein length: 1683
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2m85, 4qn1

Protein Sequence ▾

>Q149N8
MSSRRKRAPP VRVDEEKRQQ LHWNMHEDRR NEPIIISDDD EQPCPGSDTS SAHYIILSDS
LKEEVAHRDK KRCSKVVSFS KPIEKEETVG IFSPLSVKLN IVISPYHFDN SWKAFLGELT
LQLLPAQSLI ENFSERSITL MSSESSNQFL IYVHSKGEDV EKQKKEPMSI CDKGILVESS
FSGEMLEDLG WLQKKRRIKL YQKPEGNHII KVGIYLLEAG LAKLDFLSDA NSRMKKFNQL
MKKVMEKLHN SIIPDVLEED EDDPESEPEG QDIDELYHFV KQTHQQETQS IQVDVQHPAL
IPVLRPYQRE AVNWMLQQEC FRSSPATESA LHFLWREIVT SEGLKLYYNP YTGCIIREYP
NSGPQLLGGI LADEMGLGKT VEVLALILTH TRQDVKQDAL TLPEGKVVNY FIPSHYFGGK
LKKTEIQNIE FEPKEKVQCP PTRVMILTAV KEMNGKKGVS ILSIYKYVSS IYRYDVQRNR
SLLKRMLKCL IFEGLVKQIK GHGFSGTFTL GKNYKEEDIC DKTKKQAVGS PRKIQKETRK
SGNKDTDSEY LPSDTSDDDD DPYYYYYKSR RNRSKLRKKL VPSTKKGKSQ PFINPDSQGH
CPATSDSGIT DVAMSKSTCI SEFNQEHETE DCAESLNHAD SDVPPSNTMS PFNTSDYRFE
CICGELDQID RKPRVQCLKC HLWQHAKCVN YDEKNLKIKP FYCPHCLVAM EPVSTRATLI
ISPSSICHQW VDEINRHVRS SSLRVLVYQG VKKDGFLQPH FLAEQDIVII TYDVLRSELN
YVDIPHSNSE DGRRLRNQKR YMAIPSPLVA VEWWRICLDE AQMVECPTVK AAEMAQRLSG
INRWCISGTP VQRGLEDLFG LVVFLGIEPY CVKHWWVRLL YRPYCKKNPQ HLYSFIAKIL
WRSAKKDVID QIQIPPQTEE IHWLHFSPVE RHFYHRQHEV CCQDVVVKLR KISDWALKLS
SLDRRTVTSI LYPLLRLRQA CCHPQAVRGE FLPLQKSTMT MEELLTSLQK KCGTECEEAH
RQLVCALNGL AGIHIIKGEY ALAAELYREV LRSSEEHKGK LKTDSLQRLH ATHNLMELLI
ARHPGIPPTL RDGRLEEEAK QLREHYMSKC NTEVAEAQQA LYPVQQTIHE LQRKIHSNSP
WWLNVIHRAI EFTIDEELVQ RVRNEITSNY KQQTGKLSMS EKFRDCRGLQ FLLTTQMEEL
NKCQKLVREA VKNLEGPPSR NVIESATVCH LRPARLPLNC CVFCKADELF TEYESKLFSN
TVKGQTAIFE EMIEDEEGLV DDRAPTTTRG LWAISETERS MKAILSFAKS HRFDVEFVDE
GSTSMDLFEA WKKEYKLLHE YWMALRNRVS AVDELAMATE RLRVRDPREP KPNPPVLHII
EPHEVEQNRI KLLNDKAVAT SQLQKKLGQL LYLTNLEKSQ DKTSGGVNPE PCPICARQLG
KQWAVLTCGH CFCNECISII IEQYSVGSHR SSIKCAICRQ TTSHKEISYV FTSEKANQEE
DIPVKGSHST KVEAVVRTLM KIQLRDPGAK ALVFSTWQDV LDIISKALTD NNMEFAQISR
VKTFQENLSA FKRDPQINIL LLPLHTGSNG LTIIEATHVL LVEPILNPAH ELQAIGRVHR
IGQTKPTIVH RFLIKATIEE RMQAMLKTAE RSHTNSSAKH SEASVLTVAD LADLFTKETE
ELE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
260	395	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
273	407	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
300	875	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	SM00487
307	987	Domain	SNF2, N-terminal	IPR000330	PF00176
436	502	Domain	Linker histone H1/H5, domain H15	IPR005818	SM00526
436	515	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
438	512	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
438	512	Domain	Linker histone H1/H5, domain H15	IPR005818	PS51504
440	510	Domain	Linker histone H1/H5, domain H15	IPR005818	PF00538
440	512	Domain	Linker histone H1/H5, domain H15	IPR005818	cd00073
647	708	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
650	717	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
660	707	Domain	Zinc finger, PHD-type	IPR001965	SM00249
661	706	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
709	923	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
715	887	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
905	1679	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
1404	1486	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1432	1479	Domain	Zinc finger, RING-type	IPR001841	PS50089
1432	1478	Domain	Zinc finger, RING-type	IPR001841	SM00184
1448	1457	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
1487	1681	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
1514	1672	Domain	Helicase, C-terminal	IPR001650	PS51194
1514	1622	Domain	Helicase, C-terminal	IPR001650	PF00271
1542	1622	Domain	Helicase, C-terminal	IPR001650	SM00490

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006334	nucleosome assembly	Biological Process	IEA	GO_REF:0000002
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000117
GO:0000786	nucleosome	Cellular Component	IEA	GO_REF:0000002
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-8943003
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0004386	helicase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:17108083
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IDA	PMID:25023518
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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