CHD4

Details:

UniProt Entry: Q14839

Gene: CHD4

Class: RING

Family: RING10

Protein length: 1912

Database confidence: 0.125

InterPro: InterPro Entry

Mode of Action: Unclassified

AlphaFold Model: Link

PDB Structures: 1mm2, 1mm3, 2ee1, 2l5u, 2l75, 2n5n, 4o9i, 6bgg, 6q3m, 6ryr, 6ryu, 8d4y

Protein Sequence ▾

>Q14839
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP
RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA LRSDSEGSDY TPGKKKKKKL
GPKKEKKSKS KRKEEEEEED DDDDSKEPKS SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA
FSQFVRPLIA AKNPKIAVSK MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM
VTATEVAPPP PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK KKKKGEEEVT
AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD MEKAPEGKWS CPHCEKEGIQ
WEAKEDNSEG EEILEEVGGD LEEEDDHHME FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL
PEIPNGEWLC PRCTCPALKG KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE
RQFFVKWQGM SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD QASWESEDVE
IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP PETPTVDPTV KYERQPEYLD
ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV
SAPLSTIINW EREFEMWAPD MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE
ASVKFHVLLT SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML GPHMLRRLKA
DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR GGGNQVSLLN VVMDLKKCCN
HPYLFPVAAM EAPKMPNGMY DGSALIRASG KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD
LLEDFLEHEG YKYERIDGGI TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT
VIIYDSDWNP HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD DKAIERLLDR
NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER EIIKQEESVD PDYWEKLLRH
HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ EDRDWQDDQS DNQSDYSVAS EEGDEDFDER
SEAPRRPSRK GLRNDKDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT
TQWLVRDLRG KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ PNTPAPVPPA
EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP ASEDEKVVVE PPEGEEKVEK
AEVKERTEEP METEPKGAAD VEKVEEKSAI DLTPIVVEDK EEKKEEEEKK EVMLQNGETP
KDLNDEKQKK NIKQRFMFNI ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG
IINHGYARWQ DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL HKVLKQLEEL
LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA PEPTPQQVAQ QQ

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
164	217	Domain	CHD, N-terminal	IPR012958	PF08073
342	416	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
361	420	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
370	417	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
372	416	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
372	415	Domain	Zinc finger, PHD-type	IPR001965	SM00249
373	414	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
442	501	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
449	496	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
451	494	Domain	Zinc finger, PHD-type	IPR001965	SM00249
451	495	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
452	493	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
464	584	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
499	579	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
529	586	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
606	675	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
620	677	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
622	657	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
623	673	Domain	Chromo domain	IPR023780	PF00385
705	957	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
722	934	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	SM00487
722	966	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
738	922	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	PS51192
744	1024	Domain	SNF2, N-terminal	IPR000330	PF00176
868	877	Conserved_site	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	IPR002464	PS00690
959	1229	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
967	1195	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
1051	1164	Domain	Helicase, C-terminal	IPR001650	PF00271
1054	1203	Domain	Helicase, C-terminal	IPR001650	PS51194
1080	1164	Domain	Helicase, C-terminal	IPR001650	SM00490
1289	1353	Domain	Domain of unknown function DUF1087	IPR009463	SM01147
1294	1352	Domain	Domain of unknown function DUF1087	IPR009463	PF06465
1366	1523	Domain	CHD subfamily II, SANT-like domain	IPR009462	SM01146
1383	1520	Domain	CHD subfamily II, SANT-like domain	IPR009462	PF06461
1726	1871	Domain	CHD, C-terminal 2	IPR012957	PF08074

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000120
GO:0015671	oxygen transport	Biological Process	IDA	PMID:19065339
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IMP	PMID:25593309
GO:0010629	negative regulation of gene expression	Biological Process	IGI	PMID:33301730
GO:0042659	regulation of cell fate specification	Biological Process	NAS	PMID:22560079
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	NAS	PMID:22560079
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	NAS	PMID:19927129
GO:0051963	regulation of synapse assembly	Biological Process	IEA	GO_REF:0000107
GO:0072553	terminal button organization	Biological Process	IEA	GO_REF:0000107
GO:2000736	regulation of stem cell differentiation	Biological Process	NAS	PMID:22560079
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0016581	NuRD complex	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000117
GO:0150048	cerebellar granule cell to Purkinje cell synapse	Cellular Component	IEA	GO_REF:0000107
GO:0000781	chromosome, telomeric region	Cellular Component	IDA	PMID:25150861
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0090734	site of DNA damage	Cellular Component	IDA	PMID:25593309
GO:0032991	protein-containing complex	Cellular Component	HDA	PMID:16217013
GO:0090575	RNA polymerase II transcription regulator complex	Cellular Component	IDA	PMID:29795351
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0004386	helicase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IEA	GO_REF:0000117
GO:0031492	nucleosomal DNA binding	Molecular Function	HDA	PMID:16217013
GO:0001221	transcription coregulator binding	Molecular Function	IPI	PMID:29795351
GO:0003682	chromatin binding	Molecular Function	IBA	GO_REF:0000033
GO:0003714	transcription corepressor activity	Molecular Function	IDA	PMID:33859416
GO:0005515	protein binding	Molecular Function	IPI	PMID:10220385
GO:0016887	ATP hydrolysis activity	Molecular Function	IBA	GO_REF:0000033
GO:0042393	histone binding	Molecular Function	IBA	GO_REF:0000033
GO:0042826	histone deacetylase binding	Molecular Function	IPI	PMID:27616479
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Molecular Function	IPI	PMID:22926524
GO:0140658	ATP-dependent chromatin remodeler activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL2103840	ChEMBL	8.52	—	—	CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12

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