KCNB1

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
23	152	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
31	140	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
31	140	Domain	BTB/POZ domain	IPR000210	SM00225
33	132	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
82	92	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
130	143	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
161	313	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
165	179	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
189	423	Domain	Ion transport domain	IPR005821	PF00520
253	266	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
306	314	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
330	344	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
394	405	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
401	412	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
417	428	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
451	466	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PR01495
467	478	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
467	613	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PF03521
508	520	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
524	536	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
538	549	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
576	587	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
649	680	Family	Potassium channel, voltage dependent, Kv2	IPR003973	PF03521
726	737	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514
755	769	Family	Potassium channel, voltage dependent, Kv2.1	IPR004350	PR01514

GO term	Name	Ontology	Evidence	Reference
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006887	exocytosis	Biological Process	IEA	GO_REF:0000043
GO:0006904	vesicle docking involved in exocytosis	Biological Process	ISS	GO_REF:0000024
GO:0007215	glutamate receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0010701	positive regulation of norepinephrine secretion	Biological Process	ISS	GO_REF:0000024
GO:0031669	cellular response to nutrient levels	Biological Process	ISS	GO_REF:0000024
GO:0033605	positive regulation of catecholamine secretion	Biological Process	ISS	GO_REF:0000024
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0042593	glucose homeostasis	Biological Process	ISS	GO_REF:0000024
GO:0045163	clustering of voltage-gated potassium channels	Biological Process	IEA	GO_REF:0000107
GO:0045956	positive regulation of calcium ion-dependent exocytosis	Biological Process	ISS	GO_REF:0000024
GO:0046676	negative regulation of insulin secretion	Biological Process	ISS	GO_REF:0000024
GO:0048678	response to axon injury	Biological Process	IEA	GO_REF:0000107
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071277	cellular response to calcium ion	Biological Process	IEA	GO_REF:0000107
GO:0071333	cellular response to glucose stimulus	Biological Process	ISS	GO_REF:0000024
GO:0071805	potassium ion transmembrane transport	Biological Process	ISS	GO_REF:0000024
GO:0072659	protein localization to plasma membrane	Biological Process	ISS	GO_REF:0000024
GO:0090314	positive regulation of protein targeting to membrane	Biological Process	ISS	GO_REF:0000024
GO:0097623	potassium ion export across plasma membrane	Biological Process	IEA	GO_REF:0000107
GO:0098900	regulation of action potential	Biological Process	ISS	GO_REF:0000024
GO:1900454	positive regulation of long-term synaptic depression	Biological Process	ISS	GO_REF:0000024
GO:1902065	response to L-glutamate	Biological Process	IEA	GO_REF:0000107
GO:2000671	regulation of motor neuron apoptotic process	Biological Process	ISS	GO_REF:0000024
GO:0030424	axon	Cellular Component	IBA	GO_REF:0000033
GO:0032590	dendrite membrane	Cellular Component	IBA	GO_REF:0000033
GO:0032809	neuronal cell body membrane	Cellular Component	IBA	GO_REF:0000033
GO:0045211	postsynaptic membrane	Cellular Component	IBA	GO_REF:0000033
GO:0098981	cholinergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099634	postsynaptic specialization membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0009986	cell surface	Cellular Component	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016324	apical plasma membrane	Cellular Component	IEA	GO_REF:0000107
GO:0016328	lateral plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0030425	dendrite	Cellular Component	ISS	GO_REF:0000024
GO:0042383	sarcolemma	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043005	neuron projection	Cellular Component	IEA	GO_REF:0000043
GO:0043025	neuronal cell body	Cellular Component	IEA	GO_REF:0000107
GO:0043204	perikaryon	Cellular Component	ISS	GO_REF:0000024
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000120
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:1990635	proximal dendrite	Cellular Component	IEA	GO_REF:0000107
GO:0008076	voltage-gated potassium channel complex	Cellular Component	ISS	GO_REF:0000024
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0000149	SNARE binding	Molecular Function	IEA	GO_REF:0000107
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000120
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	ISS	GO_REF:0000024
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:10484328
GO:0015271	outward rectifier potassium channel activity	Molecular Function	IEA	GO_REF:0000107
GO:0015459	potassium channel regulator activity	Molecular Function	IBA	GO_REF:0000033
GO:0044325	transmembrane transporter binding	Molecular Function	IEA	GO_REF:0000107
GO:0046982	protein heterodimerization activity	Molecular Function	ISS	GO_REF:0000024

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3577208	ChEMBL	6.23	—	—	COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1C1=C(c2c(OC)cccc2OC)c2c(O)cc(C)c(OC)c2C1=O
E3 Binder	CHEMBL3577209	ChEMBL	6.0	—	—	COc1cccc(OC)c1C(=O)c1c(O)cc(C)c(OC)c1CC(=O)c1c(OC)c(C)cc(O)c1C(=O)c1c(OC)cccc1OC

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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

KCNB1

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾