HLTF

Details:

UniProt Entry: Q14527
Gene: HLTF
Class: RING
Family: RING10
Protein length: 1009
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2mzn, 4hre, 4hrh, 4s0n, 4xzf, 4xzg, 5bnh, 5k5f, 6kcs

Protein Sequence ▾

>Q14527
MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA
YIMDNKLAQI EGVVPFGANN AFTMPLHMTF WGKEENRKAV SDQLKKHGFK LGPAPKTLGF
NLESGWGSGR AGPSYSMPVH AAVQMTTEQL KTEFDKLFED LKEDDKTHEM EPAEAIETPL
LPHQKQALAW MVSRENSKEL PPFWEQRNDL YYNTITNFSE KDRPENVHGG ILADDMGLGK
TLTAIAVILT NFHDGRPLPI ERVKKNLLKK EYNVNDDSMK LGGNNTSEKA DGLSKDASRC
SEQPSISDIK EKSKFRMSEL SSSRPKRRKT AVQYIESSDS EEIETSELPQ KMKGKLKNVQ
SETKGRAKAG SSKVIEDVAF ACALTSSVPT TKKKMLKKGA CAVEGSKKTD VEERPRTTLI
ICPLSVLSNW IDQFGQHIKS DVHLNFYVYY GPDRIREPAL LSKQDIVLTT YNILTHDYGT
KGDSPLHSIR WLRVILDEGH AIRNPNAQQT KAVLDLESER RWVLTGTPIQ NSLKDLWSLL
SFLKLKPFID REWWHRTIQR PVTMGDEGGL RRLQSLIKNI TLRRTKTSKI KGKPVLELPE
RKVFIQHITL SDEERKIYQS VKNEGRATIG RYFNEGTVLA HYADVLGLLL RLRQICCHTY
LLTNAVSSNG PSGNDTPEEL RKKLIRKMKL ILSSGSDEEC AICLDSLTVP VITHCAHVFC
KPCICQVIQN EQPHAKCPLC RNDIHEDNLL ECPPEELARD SEKKSDMEWT SSSKINALMH
ALTDLRKKNP NIKSLVVSQF TTFLSLIEIP LKASGFVFTR LDGSMAQKKR VESIQCFQNT
EAGSPTIMLL SLKAGGVGLN LSAASRVFLM DPAWNPAAED QCFDRCHRLG QKQEVIITKF
IVKDSVEENM LKIQNKKREL AAGAFGTKKP NADEMKQAKI NEIRTLIDL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
60	154	Domain	HIRAN domain	IPR014905	SM00910
61	152	Domain	HIRAN domain	IPR014905	PF08797
206	328	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
214	644	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
236	614	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	SM00487
243	721	Domain	SNF2, N-terminal	IPR000330	PF00176
435	606	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	PS51192
456	645	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
651	1008	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
659	1009	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
740	813	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
760	801	Domain	Zinc finger, RING-type	IPR001841	PS50089
760	800	Domain	Zinc finger, RING-type	IPR001841	SM00184
775	784	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
834	950	Domain	Helicase, C-terminal	IPR001650	PF00271
837	996	Domain	Helicase, C-terminal	IPR001650	PS51194
865	950	Domain	Helicase, C-terminal	IPR001650	SM00490

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IDA	PMID:18316726
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:18316726
GO:0006281	DNA repair	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0042789	mRNA transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0050767	regulation of neurogenesis	Biological Process	IEA	GO_REF:0000107
GO:0071932	replication fork reversal	Biological Process	IDA	PMID:19948885
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	NAS	PMID:3126079
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0016363	nuclear matrix	Cellular Component	NAS	PMID:23415230
GO:0043596	nuclear replication fork	Cellular Component	IC	PMID:19948885
GO:0090575	RNA polymerase II transcription regulator complex	Cellular Component	IEA	GO_REF:0000107
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003824	catalytic activity	Molecular Function	IEA	GO_REF:0000043
GO:0004386	helicase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Molecular Function	IEA	GO_REF:0000002
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003697	single-stranded DNA binding	Molecular Function	IDA	PMID:26051180
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:10391891
GO:0008094	ATP-dependent activity, acting on DNA	Molecular Function	IBA	GO_REF:0000033
GO:0015616	DNA translocase activity	Molecular Function	IDA	PMID:19948885
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IDA	PMID:25023518
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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