HIC1

Details:

UniProt Entry: Q14526
Gene: HIC1
Class: RING
Family: RING6
Protein length: 733
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q14526
MTFPEADILL KSGECAGQTM LDTMEAPGHS RQLLLQLNNQ RTKGFLCDVI IVVQNALFRA
HKNVLAASSA YLKSLVVHDN LLNLDHDMVS PAVFRLVLDF IYTGRLADGA EAAAAAAVAP
GAEPSLGAVL AAASYLQIPD LVALCKKRLK RHGKYCHLRG GGGGGGGYAP YGRPGRGLRA
ATPVIQACYP SPVGPPPPPA AEPPSGPEAA VNTHCAELYA SGPGPAAALC ASERRCSPLC
GLDLSKKSPP GSAAPERPLA ERELPPRPDS PPSAGPAAYK EPPLALPSLP PLPFQKLEEA
APPSDPFRGG SGSPGPEPPG RPDGPSLLYR WMKHEPGLGS YGDELGRERG SPSERCEERG
GDAAVSPGGP PLGLAPPPRY PGSLDGPGAG GDGDDYKSSS EETGSSEDPS PPGGHLEGYP
CPHLAYGEPE SFGDNLYVCI PCGKGFPSSE QLNAHVEAHV EEEEALYGRA EAAEVAAGAA
GLGPPFGGGG DKVAGAPGGL GELLRPYRCA SCDKSYKDPA TLRQHEKTHW LTRPYPCTIC
GKKFTQRGTM TRHMRSHLGL KPFACDACGM RFTRQYRLTE HMRIHSGEKP YECQVCGGKF
AQQRNLISHM KMHAVGGAAG AAGALAGLGG LPGVPGPDGK GKLDFPEGVF AVARLTAEQL
SLKQQDKAAA AELLAQTTHF LHDPKVALES LYPLAKFTAE LGLSPDKAAE VLSQGAHLAA
GPDGRTIDRF SPT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
22	157	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
24	151	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
37	152	Domain	BTB/POZ domain	IPR000210	PF00651
47	110	Domain	BTB/POZ domain	IPR000210	PS50097
47	153	Domain	BTB/POZ domain	IPR000210	SM00225
433	463	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
437	459	Domain	Zinc finger C2H2-type	IPR013087	SM00355
437	464	Domain	Zinc finger C2H2-type	IPR013087	PS50157
439	459	Domain	Zinc finger C2H2-type	IPR013087	PS00028
505	557	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
507	529	Domain	Zinc finger C2H2-type	IPR013087	PF00096
507	534	Domain	Zinc finger C2H2-type	IPR013087	PS50157
507	529	Domain	Zinc finger C2H2-type	IPR013087	SM00355
509	529	Domain	Zinc finger C2H2-type	IPR013087	PS00028
535	557	Domain	Zinc finger C2H2-type	IPR013087	SM00355
535	562	Domain	Zinc finger C2H2-type	IPR013087	PS50157
535	557	Domain	Zinc finger C2H2-type	IPR013087	PF00096
537	557	Domain	Zinc finger C2H2-type	IPR013087	PS00028
544	600	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
563	585	Domain	Zinc finger C2H2-type	IPR013087	SM00355
563	590	Domain	Zinc finger C2H2-type	IPR013087	PS50157
563	585	Domain	Zinc finger C2H2-type	IPR013087	PF00096
565	585	Domain	Zinc finger C2H2-type	IPR013087	PS00028
591	613	Domain	Zinc finger C2H2-type	IPR013087	SM00355
591	614	Domain	Zinc finger C2H2-type	IPR013087	PS50157
591	613	Domain	Zinc finger C2H2-type	IPR013087	PF00096
593	613	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0006355	regulation of DNA-templated transcription	Biological Process	TAS	PMID:7585125
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Biological Process	IEA	GO_REF:0000120
GO:0009966	regulation of signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0030178	negative regulation of Wnt signaling pathway	Biological Process	IDA	PMID:16724116
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-4090281
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:15231840
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IDA	PMID:15231840
GO:0005515	protein binding	Molecular Function	IPI	PMID:12052894
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0042826	histone deacetylase binding	Molecular Function	IDA	PMID:12052894
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:15231840
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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