| E3 Binder |
CHEMBL5078020 |
ChEMBL |
7.54 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3cc(C)c(C(=O)O)c(C)c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5089816 |
ChEMBL |
7.57 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3cc(F)c(C(=O)O)c(F)c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5092330 |
ChEMBL |
6.42 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(-c4nnn[nH]4)cc3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5087851 |
ChEMBL |
7.43 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)c(C(F)(F)F)c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5070545 |
ChEMBL |
7.37 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)c(C)c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5077539 |
ChEMBL |
7.48 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)c(F)c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5082511 |
ChEMBL |
7.54 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)c([N+](=O)[O-])c3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5092602 |
ChEMBL |
7.39 |
9P0 |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)cc3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5091126 |
ChEMBL |
7.36 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2cccc(-c3ccc(C(=O)O)s3)c2CSC[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL5089493 |
ChEMBL |
6.0 |
— |
— |
CC(=O)N1CCC[C@H]1C(=O)N[C@@H]1COC(=O)c2ccccc2C[S+]([O-])C[C@H](C(=O)N(C)C)NC1=O |
| E3 Binder |
CHEMBL4174405 |
ChEMBL |
7.68 |
— |
— |
CC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3928693 |
ChEMBL |
6.94 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3965182 |
ChEMBL |
6.2 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL3908796 |
ChEMBL |
6.61 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL5272223 |
ChEMBL |
7.51 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N1CSC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1CCCCC1)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3970907 |
ChEMBL |
6.14 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3617787 |
ChEMBL |
6.71 |
— |
— |
CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3982888 |
ChEMBL |
7.53 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3965115 |
ChEMBL |
7.37 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL4746924 |
ChEMBL |
7.72 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4762897 |
ChEMBL |
8.0 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CSC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4747777 |
ChEMBL |
6.68 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O |
| E3 Binder |
CHEMBL4749322 |
ChEMBL |
6.72 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)(C)O |
| E3 Binder |
CHEMBL4754176 |
ChEMBL |
7.89 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4776337 |
ChEMBL |
7.16 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4534676 |
ChEMBL |
7.64 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL3134422 |
ChEMBL |
7.67 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4750670 |
ChEMBL |
6.78 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4787250 |
ChEMBL |
6.94 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4796106 |
ChEMBL |
7.04 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4752720 |
ChEMBL |
6.55 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4750619 |
ChEMBL |
7.26 |
— |
— |
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O)C(C)C |
| E3 Binder |
CHEMBL3919787 |
ChEMBL |
6.06 |
— |
— |
CC(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL4177337 |
ChEMBL |
7.64 |
— |
— |
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)O |
| E3 Binder |
CHEMBL4743599 |
ChEMBL |
6.37 |
— |
— |
CC(=O)N[C@H]1C/C=C/C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4785587 |
ChEMBL |
7.36 |
— |
— |
CC(=O)N[C@H]1CCC(=O)NCC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4760303 |
ChEMBL |
7.96 |
— |
— |
CC(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4759189 |
ChEMBL |
6.97 |
— |
— |
CC(=O)N[C@H]1CCCC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4754751 |
ChEMBL |
7.47 |
— |
— |
CC(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4794133 |
ChEMBL |
7.8 |
— |
— |
CC(=O)N[C@H]1CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL3913014 |
ChEMBL |
8.03 |
— |
— |
CC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC1=O |
| E3 Binder |
CHEMBL4239409 |
ChEMBL |
7.32 |
— |
— |
CC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4760005 |
ChEMBL |
7.26 |
— |
— |
CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4250785 |
ChEMBL |
7.02 |
— |
— |
CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4247618 |
ChEMBL |
7.32 |
— |
— |
CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC1=O |
| E3 Binder |
CHEMBL4248736 |
ChEMBL |
8.21 |
— |
— |
CC(=O)N[C@H]1CSc2c(F)c(F)c(c(F)c2F)SC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4238711 |
ChEMBL |
7.21 |
— |
— |
CC(=O)N[C@H]1CSc2c(F)c(F)c(c(F)c2F)SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC1=O |
| E3 Binder |
CHEMBL4778658 |
ChEMBL |
7.04 |
— |
— |
CC(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4741548 |
ChEMBL |
6.01 |
— |
— |
CC(=O)Nc1ccc(C(Oc2ccc(N(CC(=O)O)S(=O)(=O)c3c(C)cc(C)cc3C)c3ccccc23)C(=O)O)cc1 |
| E3 Binder |
CHEMBL3601212 |
ChEMBL |
7.87 |
— |
— |
CC(=O)Nc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(NC(C)=O)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4515723 |
ChEMBL |
6.21 |
— |
— |
CC(=O)Nc1ccc(S(=O)(=O)N(Cc2c[nH]nn2)c2ccc(N(Cc3c[nH]nn3)S(=O)(=O)c3ccc(NC(C)=O)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4544116 |
ChEMBL |
7.8 |
— |
— |
CC(=O)Nc1ccc(S(=O)(=O)N(Cc2nn[nH]n2)c2ccc(N(Cc3nn[nH]n3)S(=O)(=O)c3ccc(NC(C)=O)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3601213 |
ChEMBL |
7.3 |
— |
— |
CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C(C)(C)C)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4748615 |
ChEMBL |
6.01 |
— |
— |
CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccccc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5285536 |
ChEMBL |
7.32 |
— |
— |
CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)CC[C@@H]2NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@H](Cc3ccccc3)NC2=O)C(N)=O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4169002 |
ChEMBL |
8.21 |
— |
— |
CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL3423017 |
ChEMBL |
6.0 |
— |
— |
CC(C)C[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)O |
| E3 Binder |
CHEMBL4790062 |
ChEMBL |
8.32 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O)C(C)C |
| E3 Binder |
CHEMBL4788971 |
ChEMBL |
8.44 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H]1CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O)C(C)C |
| E3 Binder |
CHEMBL3421645 |
ChEMBL |
7.52 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O |
| E3 Binder |
CHEMBL3423015 |
ChEMBL |
6.45 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)O |
| E3 Binder |
CHEMBL3975863 |
ChEMBL |
6.45 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL2402205 |
ChEMBL |
7.54 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)O |
| E3 Binder |
CHEMBL3632891 |
ChEMBL |
7.6 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)c1cc(N=C=S)ccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL3966742 |
ChEMBL |
7.59 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)c1ccc(N=C=S)cc1C1c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL3237244 |
ChEMBL |
7.8 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL4792032 |
ChEMBL |
7.96 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1C[C@H](F)CN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(C)C)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL4751630 |
ChEMBL |
7.7 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1C[C@H](F)CN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL4788462 |
ChEMBL |
7.62 |
— |
— |
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(F)cc(F)c1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1C[C@H](F)CN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(N)=O |
| E3 Binder |
CHEMBL5084845 |
ChEMBL |
8.24 |
— |
— |
CC1(C)CC2(C=C(C#N)C1=O)CN(c1ccccn1)CCO2 |
| E3 Binder |
CHEMBL5079553 |
ChEMBL |
8.51 |
— |
— |
CC1(C)CC2(C=C(C#N)C1=O)CN(c1cccnc1)CCO2 |
| E3 Binder |
CHEMBL5085834 |
ChEMBL |
8.49 |
— |
— |
CC1(C)CC2(C=C(C#N)C1=O)CN(c1ccncc1F)CCO2 |
| E3 Binder |
CHEMBL5090792 |
ChEMBL |
8.54 |
— |
— |
CC1(C)CC2(C=C(C#N)C1=O)OCc1cc(Cl)ccc12 |
| E3 Binder |
CHEMBL5275894 |
ChEMBL |
7.01 |
— |
— |
CC1(C)OB(c2ccc(COn3c(C(=O)NCc4ccc(-c5ccccc5)cc4)cccc3=O)cc2)OC1(C)C |
| E3 Binder |
CHEMBL5207900 |
ChEMBL |
6.64 |
— |
— |
CCCC1CCCCN1C(=O)C1CCCC(c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)C1 |
| E3 Binder |
CHEMBL5175068 |
ChEMBL |
6.66 |
— |
— |
CCCC1CCCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3c3cccnc3)c2)c1 |
| E3 Binder |
CHEMBL4440989 |
ChEMBL |
7.89 |
— |
— |
CCCCC1CCCN1C(=O)[C@@H]1CCC[C@H](c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)C1 |
| E3 Binder |
CHEMBL5277720 |
ChEMBL |
7.2 |
— |
— |
CCCCC1CCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1 |
| E3 Binder |
CHEMBL3946369 |
ChEMBL |
7.66 |
— |
— |
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O |
| E3 Binder |
CHEMBL5207192 |
ChEMBL |
6.37 |
— |
— |
CCCCOc1cc(N(CC(=O)O)S(=O)(=O)c2ccc(OC)cc2)ccc1N(CC(=O)O)S(=O)(=O)c1ccc(OC)cc1 |
| E3 Binder |
CHEMBL4175603 |
ChEMBL |
8.0 |
— |
— |
CCCC[C@@H]1CCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1 |
| E3 Binder |
CHEMBL3601221 |
ChEMBL |
7.38 |
— |
— |
CCCCc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(CCCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4872361 |
ChEMBL |
6.4 |
QH8 |
— |
CCCCc1ccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)cc1 |
| E3 Binder |
CHEMBL5174036 |
ChEMBL |
6.37 |
— |
— |
CCCOc1cc(N(CC(=O)O)S(=O)(=O)c2ccc(OC)cc2)ccc1N(CC(=O)O)S(=O)(=O)c1ccc(OC)cc1 |
| E3 Binder |
CHEMBL5208399 |
ChEMBL |
7.22 |
— |
— |
CCC[C@H]1CCCCN1C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1F |
| E3 Binder |
CHEMBL4850809 |
ChEMBL |
6.47 |
— |
— |
CCCc1ccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)cc1 |
| E3 Binder |
CHEMBL4857893 |
ChEMBL |
7.1 |
— |
— |
CCCc1ccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3[C@H]3C[C@@H]3c3ccccc3)c2)cc1 |
| E3 Binder |
CHEMBL1398345 |
ChEMBL |
6.15 |
— |
— |
CCN1C(=O)c2cccc3c(N)ccc(c23)C1=O |
| E3 Binder |
CHEMBL5184256 |
ChEMBL |
6.32 |
— |
— |
CCN1CCN(CC(=O)Nc2ccc(S(=O)(=O)N(CC(N)=O)c3ccc(N(CC(N)=O)S(=O)(=O)c4ccc(OC)cc4)c4ccccc34)cc2)CC1 |
| E3 Binder |
CHEMBL5185586 |
ChEMBL |
6.68 |
— |
— |
CCN1CCN(CCC(=O)Nc2ccc(S(=O)(=O)N(CC(N)=O)c3ccc(N(CC(N)=O)S(=O)(=O)c4ccc(OC)cc4)c4ccccc34)cc2)CC1 |
| E3 Binder |
CHEMBL5194748 |
ChEMBL |
6.24 |
— |
— |
CCN1CCN(CCCC(=O)Nc2ccc(S(=O)(=O)N(CC(N)=O)c3ccc(N(CC(N)=O)S(=O)(=O)c4ccc(OC)cc4)c4ccccc34)cc2)CC1 |
| E3 Binder |
CHEMBL1606122 |
ChEMBL |
6.06 |
— |
— |
CCNc1ccc2noc3c2c1C(=O)c1ccccc1-3 |
| E3 Binder |
CHEMBL3632882 |
ChEMBL |
7.07 |
— |
— |
CCOC(=O)CN(c1ccc(NS(=O)(=O)c2ccc(OC)cc2)c2ccccc12)S(=O)(=O)c1ccc(OC)cc1 |
| E3 Binder |
CHEMBL5203566 |
ChEMBL |
6.3 |
— |
— |
CCOc1cc(N(CC(=O)O)S(=O)(=O)c2ccc(OC)cc2)ccc1N(CC(=O)O)S(=O)(=O)c1ccc(OC)cc1 |
| E3 Binder |
CHEMBL4764502 |
ChEMBL |
6.82 |
— |
— |
CCOc1ccc(C(Oc2ccc(N(CC(=O)O)S(=O)(=O)c3c(C)cc(C)cc3C)c3ccccc23)C(=O)O)cc1 |
| E3 Binder |
CHEMBL4757197 |
ChEMBL |
7.32 |
— |
— |
CCOc1ccc(S(=O)(=O)NC(=O)CN(c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)S(=O)(=O)c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL3906697 |
ChEMBL |
6.64 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(CC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3928944 |
ChEMBL |
6.72 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(CCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3962296 |
ChEMBL |
6.82 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(CCCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3925906 |
ChEMBL |
6.75 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(SCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3953535 |
ChEMBL |
6.43 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(SCC(=O)OC)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3934789 |
ChEMBL |
6.0 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4083845 |
ChEMBL |
6.8 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc3c(C(=O)NN)c(C)n(S(=O)(=O)c4ccc(OCC)cc4)c3c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4077198 |
ChEMBL |
8.68 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc3c(C(=O)NO)c(C)n(S(=O)(=O)c4ccc(OCC)cc4)c3c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5273301 |
ChEMBL |
6.7 |
— |
— |
CCOc1ccc(S(=O)(=O)Nc2cc3c(C(=O)NO)cn(S(=O)(=O)c4ccc(OCC)cc4)c3c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4633657 |
ChEMBL |
9.06 |
— |
— |
CC[C@H](C(=O)O)[C@@H](c1ccc2c(c1)CN(C(=O)c1c(C)c(C)cc(C)c1C)CC2)c1ccc2c(nnn2CC)c1C |
| E3 Binder |
CHEMBL5285539 |
ChEMBL |
7.37 |
— |
— |
CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc2ccc(cc2)OCCSC[C@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC1=O |
| E3 Binder |
CHEMBL5286131 |
ChEMBL |
7.29 |
— |
— |
CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCSC)CSSC[C@@H](C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL2069630 |
ChEMBL |
7.21 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O |
| E3 Binder |
CHEMBL4755277 |
ChEMBL |
8.33 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)N1CCC[C@H]1C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4756743 |
ChEMBL |
8.12 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCC[C@H]1C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4756985 |
ChEMBL |
7.26 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4750320 |
ChEMBL |
7.52 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O |
| E3 Binder |
CHEMBL4781886 |
ChEMBL |
8.32 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4747827 |
ChEMBL |
8.38 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4748504 |
ChEMBL |
7.0 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O)C(C)C |
| E3 Binder |
CHEMBL4785277 |
ChEMBL |
7.58 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O)C(C)C |
| E3 Binder |
CHEMBL4740544 |
ChEMBL |
7.77 |
— |
— |
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H]1CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O)C(C)C |
| E3 Binder |
CHEMBL5266474 |
ChEMBL |
6.34 |
— |
— |
CCc1ccc(S(=O)(=O)N(CC(=O)O)c2cc(Sc3nc[nH]n3)c(O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4794097 |
ChEMBL |
6.72 |
— |
— |
CCc1ccc(S(=O)(=O)NC(=O)CN(c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)S(=O)(=O)c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL4635041 |
ChEMBL |
7.87 |
08A |
— |
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3cc(C)c4c(c3)CN(C(=O)c3ccccc3)CC4)ccc21 |
| E3 Binder |
CHEMBL4643134 |
ChEMBL |
9.15 |
— |
— |
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)ccc21 |
| E3 Binder |
CHEMBL4640695 |
ChEMBL |
7.69 |
— |
— |
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3c(F)cccc3F)CC4)ccc21 |
| E3 Binder |
CHEMBL4642419 |
ChEMBL |
8.57 |
PKG |
— |
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3ccccc3)CC4)ccc21 |
| E3 Binder |
CHEMBL4637979 |
ChEMBL |
7.22 |
— |
— |
CCn1nnc2c(C)c([C@@H](CC(=O)O)c3ccc4c(c3)CN(C(=O)c3ccccc3C)CC4)ccc21 |
| E3 Binder |
CHEMBL4634531 |
ChEMBL |
8.72 |
— |
— |
CCn1nnc2c(C)c([C@H](c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)[C@@H](C)C(=O)O)ccc21 |
| E3 Binder |
CHEMBL4644995 |
ChEMBL |
10.15 |
— |
— |
CCn1nnc2c(C)c([C@H](c3ccc4c(c3)CN(C(=O)c3c(C)c(C)cc(C)c3C)CC4)[C@H](C)C(=O)O)ccc21 |
| E3 Binder |
CHEMBL5204388 |
ChEMBL |
6.62 |
— |
— |
CN(C)C(=O)[C@H]1CCC[C@@H](c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)C1 |
| E3 Binder |
CHEMBL5075717 |
ChEMBL |
6.04 |
— |
— |
CN(C)C(=O)[C@H]1CSCc2ccccc2C(=O)OC[C@@H](NC(=O)[C@@H]2CCCN2C(=O)CCC(=O)O)C(=O)N1 |
| E3 Binder |
CHEMBL5076271 |
ChEMBL |
6.11 |
— |
— |
CN(C)C(=O)[C@H]1CSCc2ccccc2C(=O)OC[C@@H](NC(=O)[C@@H]2CCCN2C(=O)Cn2sc3ccccc3c2=O)C(=O)N1 |
| E3 Binder |
CHEMBL5090939 |
ChEMBL |
6.0 |
— |
— |
CN(C)C(=O)[C@H]1CSCc2ccccc2C(=O)OC[C@@H](NC(=O)[C@@H]2CCCN2C(=O)c2sccc2C#N)C(=O)N1 |
| E3 Binder |
CHEMBL5178836 |
ChEMBL |
6.32 |
— |
— |
CN(C)C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C(F)(F)F)c2)c1 |
| E3 Binder |
CHEMBL5195110 |
ChEMBL |
6.0 |
5VX |
— |
CN(C)C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C(F)(F)F)n2)c1 |
| E3 Binder |
CHEMBL5169432 |
ChEMBL |
6.43 |
5QZ |
— |
CN(C)C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1 |
| E3 Binder |
CHEMBL5203783 |
ChEMBL |
7.39 |
— |
— |
CN(C)C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CC3c3cn(C)nn3)c2)c1 |
| E3 Binder |
CHEMBL5191287 |
ChEMBL |
6.0 |
— |
— |
CN(C)C(=O)c1cccc(-c2cccc(-n3ncc(C(=O)O)c3C3CCCC3)c2)c1 |
| E3 Binder |
CHEMBL5220611 |
ChEMBL |
6.23 |
— |
— |
CN(C)c1ccc(S(=O)(=O)NCc2cccc(C(NC(=O)c3cccc4c3-c3ccccc3C4=O)C(=O)O)c2)cc1 |
| E3 Binder |
CHEMBL3632705 |
ChEMBL |
6.72 |
— |
— |
CN(C)c1ccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3ccc(N(C)C)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5220492 |
ChEMBL |
6.2 |
— |
— |
CN(C)c1cccc(S(=O)(=O)NCc2cccc(C(NC(=O)c3cccc4c3-c3ccccc3C4=O)C(=O)O)c2)c1 |
| E3 Binder |
CHEMBL5221116 |
ChEMBL |
6.55 |
— |
— |
CN(C)c1cccc(S(=O)(=O)NCc2cccc([C@@H](NC(=O)c3cccc4c3-c3ccccc3C4=O)C(=O)O)c2)c1 |
| E3 Binder |
CHEMBL4570791 |
ChEMBL |
6.24 |
— |
— |
CN(Cc1cc(C(CC(=O)O)c2ccc3c(c2)nnn3C)ccc1Cl)S(=O)(=O)c1cccnc1 |
| E3 Binder |
CHEMBL3818085 |
ChEMBL |
6.57 |
0PL |
— |
CN(Cc1cc([C@H](CC(=O)O)c2ccc3c(c2)nnn3C)ccc1Cl)S(=O)(=O)c1ccccc1 |
| E3 Binder |
CHEMBL1506185 |
ChEMBL |
6.27 |
— |
— |
CN1C(=O)C(=N)c2c3ccccc3c(O)c3c(Br)ccc1c23 |
| E3 Binder |
CHEMBL1412067 |
ChEMBL |
6.08 |
— |
— |
CN1C(=O)c2cccc3c(N)ccc(c23)C1=O |
| E3 Binder |
CHEMBL4459946 |
ChEMBL |
6.2 |
— |
— |
CN1CCN(C(=O)COc2ccc(C(=O)/C=C/c3ccccc3C(F)(F)F)cc2)CC1.Cl |
| E3 Binder |
CHEMBL4441857 |
ChEMBL |
6.01 |
— |
— |
CN1CCN(C(=O)COc2ccc(C(=O)/C=C/c3ccccc3Cl)cc2)CC1.Cl |
| E3 Binder |
CHEMBL4062108 |
ChEMBL |
6.54 |
— |
— |
CNNC(=O)c1c(C)n(S(=O)(=O)c2ccc(OC)cc2)c2c1cc(NS(=O)(=O)c1ccc(OC)cc1)c1ccccc12 |
| E3 Binder |
CHEMBL1387366 |
ChEMBL |
6.4 |
— |
— |
CNc1ccc2c3c(cccc13)C(=O)N(C)C2=O |
| E3 Binder |
CHEMBL4530659 |
ChEMBL |
7.16 |
— |
— |
COC1(c2cccnc2-c2cnn(C)c2)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4565642 |
ChEMBL |
8.15 |
— |
— |
COC1(c2ncc(F)cc2-c2cnc(C)s2)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4557371 |
ChEMBL |
8.7 |
— |
— |
COC1(c2ncc(F)cc2-c2cnn(C)c2)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4584154 |
ChEMBL |
8.22 |
— |
— |
COC1(c2ncc(F)cc2Br)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4462699 |
ChEMBL |
7.75 |
— |
— |
COC1(c2ncc(F)cc2C(F)F)C=C(C#N)C(=O)C2(CC2)C1 |
| E3 Binder |
CHEMBL4542755 |
ChEMBL |
8.1 |
— |
— |
COC1(c2ncc(F)cc2OC(F)F)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4593124 |
ChEMBL |
7.25 |
— |
— |
COC1(c2ncccc2-c2cnn(C)c2)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4535670 |
ChEMBL |
7.35 |
— |
— |
COC1(c2ncccc2Br)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4463989 |
ChEMBL |
7.62 |
— |
— |
COC1(c2ncccc2C(F)(F)F)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4446699 |
ChEMBL |
8.7 |
— |
— |
CO[C@]1(c2ncc(F)cc2-c2ccns2)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4442320 |
ChEMBL |
7.48 |
— |
— |
CO[C@]1(c2ncc(F)cc2C(F)F)C=C(C#N)C(=O)C(C)(C)C1 |
| E3 Binder |
CHEMBL4583328 |
ChEMBL |
7.85 |
— |
— |
CO[C@]1(c2ncccc2C(F)F)C=C(C#N)C(=O)C2(CC2)C1 |
| E3 Binder |
CHEMBL5070465 |
ChEMBL |
7.44 |
— |
— |
COc1cc(-c2cccc3c2CSC[C@H](C(=O)N(C)C)NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(C)=O)COC3=O)ccc1C(=O)O |
| E3 Handle |
— |
PROTACDB3 |
6.0* |
LQ4 |
— |
COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC |
| E3 Binder |
CHEMBL4554007 |
ChEMBL |
7.36 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN(C)S(=O)(=O)c3ccccc3)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4567490 |
ChEMBL |
6.58 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3C(C)COc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4447060 |
ChEMBL |
7.7 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3CC(C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4540327 |
ChEMBL |
7.43 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3CCN(C)c4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4464511 |
ChEMBL |
7.46 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3CCOc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4450921 |
ChEMBL |
8.0 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3C[C@@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4457466 |
ChEMBL |
7.38 |
— |
— |
COc1cc(C(CC(=O)O)c2ccc(C)c(CN3C[C@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4454051 |
ChEMBL |
6.75 |
— |
— |
COc1cc(C(CC(=O)O)c2cccc(CN3CC(C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Handle |
— |
PROTACDB3 |
6.0* |
J6K |
— |
COc1cc([C@@H](CC(=O)O)c2ccc(C)c(CN(C)S(=O)(=O)c3ccccc3)c2)cc2nnn(C)c12 |
| E3 Handle |
CHEMBL3819587 |
PROTACDB3, ChEMBL |
9.0 |
L6I |
— |
COc1cc([C@@H](CC(=O)O)c2ccc(C)c(CN3C[C@@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4578025 |
ChEMBL |
7.62 |
— |
— |
COc1cc([C@H](CC(=O)O)c2ccc(C)c(CN3C[C@@H](C)Oc4ccccc4S3(=O)=O)c2)cc2nnn(C)c12 |
| E3 Binder |
CHEMBL4740287 |
ChEMBL |
7.62 |
— |
— |
COc1ccc(C(Oc2ccc(N(CC(=O)O)S(=O)(=O)c3c(C)cc(C)cc3C)c3ccccc23)C(=O)O)cc1 |
| E3 Binder |
CHEMBL5172151 |
ChEMBL |
6.11 |
— |
— |
COc1ccc(COc2cc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)ccc2N(CC(=O)O)S(=O)(=O)c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL4099355 |
ChEMBL |
6.77 |
— |
— |
COc1ccc(NNC(=O)c2c(C)n(S(=O)(=O)c3ccc(OC)cc3)c3c2cc(NS(=O)(=O)c2ccc(OC)cc2)c2ccccc23)cc1 |
| E3 Binder |
CHEMBL4641126 |
ChEMBL |
6.72 |
— |
— |
COc1ccc(S(=O)(=O)Cc2ccc(N(C(C)C(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4634673 |
ChEMBL |
6.17 |
— |
— |
COc1ccc(S(=O)(=O)Cc2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4647946 |
ChEMBL |
6.62 |
— |
— |
COc1ccc(S(=O)(=O)Cc2ccc(N([C@@H](C)C(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4632722 |
ChEMBL |
6.82 |
— |
— |
COc1ccc(S(=O)(=O)Cc2ccc(N([C@H](C)C(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4635609 |
ChEMBL |
6.0 |
— |
— |
COc1ccc(S(=O)(=O)N(C)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4747622 |
ChEMBL |
6.21 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)C2CC2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4789691 |
ChEMBL |
6.4 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4762197 |
ChEMBL |
6.92 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2ccc(C)cc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4763416 |
ChEMBL |
6.89 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2ccc(F)cc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4756384 |
ChEMBL |
6.29 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2ccc(O)cc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4750621 |
ChEMBL |
7.19 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2ccccc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4780799 |
ChEMBL |
6.11 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)NS(=O)(=O)c2cccnc2)c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)cc1 |
| E3 Binder |
CHEMBL4440393 |
ChEMBL |
7.51 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(NC(=O)CCCC(=O)NCCN)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4545736 |
ChEMBL |
7.67 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(NC(=O)CCCC(=O)NCCNC(=O)CCCC[C@@H]4SC[C@@H]5NC(=O)N[C@@H]54)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4476281 |
ChEMBL |
7.83 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(NC(=O)CCCC(=O)NCCNC(=S)Nc4ccc5c(c4)C(=O)OC54c5ccc(O)cc5Oc5cc(O)ccc54)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3600394 |
ChEMBL |
6.22 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OC)c2)cc1 |
| E3 Binder |
CHEMBL5197641 |
ChEMBL |
6.02 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCCCc3ccccc3)c2)cc1 |
| E3 Binder |
CHEMBL5194986 |
ChEMBL |
6.41 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccc(-c4ccccc4)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5170573 |
ChEMBL |
6.21 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccc(C)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5193318 |
ChEMBL |
6.04 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccc(F)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5181239 |
ChEMBL |
6.08 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccc(Oc4ccccc4)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5179491 |
ChEMBL |
6.32 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccc4ccccc4c3)c2)cc1 |
| E3 Binder |
CHEMBL5195422 |
ChEMBL |
6.37 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3cccc(OC)c3)c2)cc1 |
| E3 Binder |
CHEMBL5204857 |
ChEMBL |
6.1 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3cccc4ccccc34)c2)cc1 |
| E3 Binder |
CHEMBL5172581 |
ChEMBL |
6.37 |
GX8 |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3ccccc3)c2)cc1 |
| E3 Binder |
CHEMBL5169973 |
ChEMBL |
6.12 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(OCc3cccnc3)c2)cc1 |
| E3 Binder |
CHEMBL5170433 |
ChEMBL |
6.05 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c(Oc3ccc4ccccc4c3)c2)cc1 |
| E3 Binder |
CHEMBL3237245 |
ChEMBL |
8.45 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4166445 |
ChEMBL |
7.0 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ncccc23)cc1 |
| E3 Binder |
CHEMBL3600957 |
ChEMBL |
6.01 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)cc2)cc1 |
| E3 Binder |
CHEMBL4857990 |
ChEMBL |
6.74 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3Br)c3ccccc23)c(Br)c1 |
| E3 Binder |
CHEMBL4588743 |
ChEMBL |
7.54 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N3CCC[C@H]3C(=O)O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4522423 |
ChEMBL |
6.35 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N[C@@H](CC(=O)O)C(=O)O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4438752 |
ChEMBL |
6.26 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N[C@@H](CCC(=O)O)C(=O)O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4462141 |
ChEMBL |
6.23 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N[C@@H](Cc3c[nH]c4ccccc34)C(=O)O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4440603 |
ChEMBL |
6.52 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N[C@@H](Cc3ccccc3)C(=O)O)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4640093 |
ChEMBL |
6.55 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(F)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4174651 |
ChEMBL |
7.22 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4637137 |
ChEMBL |
6.62 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ncc(N(CC(=O)O)S(=O)(=O)c3ccc(F)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4641049 |
ChEMBL |
6.92 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(=O)O)c2ncc(N(CC(F)(F)F)S(=O)(=O)c3ccc(F)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4648321 |
ChEMBL |
6.89 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(F)(F)F)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(F)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4646536 |
ChEMBL |
7.14 |
Q5V |
— |
COc1ccc(S(=O)(=O)N(CC(F)(F)F)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4634168 |
ChEMBL |
7.26 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(F)F)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4856564 |
ChEMBL |
6.67 |
GFD |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc(N)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4850046 |
ChEMBL |
6.97 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc(N=C=S)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5206662 |
ChEMBL |
6.15 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc(NC(=O)CCN4CCN(C(C)C)CC4)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3632711 |
ChEMBL |
7.36 |
41P |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4860091 |
ChEMBL |
6.18 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc(S(=O)(=O)CCN=C=S)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4849182 |
ChEMBL |
6.34 |
— |
— |
COc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(N(CC(N)=O)S(=O)(=O)c3ccc([S+]([O-])CCCN=C=S)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4640762 |
ChEMBL |
6.68 |
— |
— |
COc1ccc(S(=O)(=O)N(CCF)c2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4640621 |
ChEMBL |
6.82 |
— |
— |
COc1ccc(S(=O)(=O)N(Cc2ccccc2CN([C@@H](C)C(=O)O)S(=O)(=O)c2ccc(OC)cc2)[C@@H](C)C(=O)O)cc1 |
| E3 Binder |
CHEMBL4646358 |
ChEMBL |
6.21 |
— |
— |
COc1ccc(S(=O)(=O)N(Cc2ccccc2CN([C@H](C)C(=O)O)S(=O)(=O)c2ccc(OC)cc2)[C@H](C)C(=O)O)cc1 |
| E3 Binder |
CHEMBL4858288 |
ChEMBL |
7.97 |
— |
— |
COc1ccc(S(=O)(=O)N(Cc2nnn[nH]2)c2ccc(N(Cc3nnn[nH]3)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4739983 |
ChEMBL |
7.66 |
— |
— |
COc1ccc(S(=O)(=O)NC(=O)CN(c2cccc3c2CCN3C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)c2cccc(OC)c2)S(=O)(=O)c2ccc(OC)cc2)cc1 |
| E3 Binder |
CHEMBL4070735 |
ChEMBL |
6.58 |
— |
— |
COc1ccc(S(=O)(=O)Nc2cc3c(C(=O)NNc4ccc([N+](=O)[O-])cc4)c(C)n(S(=O)(=O)c4ccc(OC)cc4)c3c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4091619 |
ChEMBL |
6.75 |
— |
— |
COc1ccc(S(=O)(=O)Nc2cc3c(C(=O)NNc4ccccc4)c(C)n(S(=O)(=O)c4ccc(OC)cc4)c3c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4632368 |
ChEMBL |
6.9 |
— |
— |
COc1ccc(S(=O)(=O)Nc2ccc(N(C(C)C(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5219681 |
ChEMBL |
7.01 |
— |
— |
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)N3CCSC3=O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3617852 |
ChEMBL |
7.54 |
Q5Y |
— |
COc1ccc(S(=O)(=O)Nc2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL2402207 |
ChEMBL |
6.6 |
IQK |
— |
COc1ccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3632881 |
ChEMBL |
6.39 |
— |
— |
COc1ccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3cccc(OC)c3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4649822 |
ChEMBL |
6.64 |
— |
— |
COc1ccc(S(=O)(=O)Nc2cnc(N(CC(=O)O)S(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4744304 |
ChEMBL |
7.24 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2c(C)cc(C)cc2C)c1 |
| E3 Binder |
CHEMBL4746187 |
ChEMBL |
6.96 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2ccc(C)cc2)c1 |
| E3 Binder |
CHEMBL4764588 |
ChEMBL |
6.24 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2ccc(F)cc2)c1 |
| E3 Binder |
CHEMBL4752539 |
ChEMBL |
6.64 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2ccc(NC(C)=O)cc2)c1 |
| E3 Binder |
CHEMBL4797348 |
ChEMBL |
6.82 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2cccc(OC)c2)c1 |
| E3 Binder |
CHEMBL4748294 |
ChEMBL |
6.62 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2ccccc2)c1 |
| E3 Binder |
CHEMBL4793592 |
ChEMBL |
6.8 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)NS(=O)(=O)c2ccccc2)S(=O)(=O)c2ccccc2OC)c1 |
| E3 Binder |
CHEMBL4764494 |
ChEMBL |
6.75 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(C)cc2OC)N2CCc3c2cccc3N(CC(=O)O)S(=O)(=O)c2c(C)cc(C)cc2C)c1 |
| E3 Binder |
CHEMBL4758373 |
ChEMBL |
6.19 |
— |
— |
COc1cccc(C(C(=O)NS(=O)(=O)c2ccc(OC)cc2OC)N2CCc3c2cccc3N(CC(=O)O)S(=O)(=O)c2c(C)cc(C)cc2C)c1 |
| E3 Binder |
CHEMBL3601219 |
ChEMBL |
7.18 |
— |
— |
COc1cccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3cccc(OC)c3)c3ccccc23)c1 |
| E3 Binder |
CHEMBL4847787 |
ChEMBL |
6.77 |
QHQ |
— |
COc1cccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1 |
| E3 Binder |
CHEMBL4860934 |
ChEMBL |
7.4 |
QHZ |
— |
COc1cccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3[C@H]3C[C@@H]3c3ccccc3)c2)c1 |
| E3 Binder |
CHEMBL5219706 |
ChEMBL |
7.4 |
— |
— |
COc1cccc(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(C)=O)c3[C@H]3C[C@@H]3c3ccccc3)c2)c1 |
| E3 Binder |
CHEMBL3632699 |
ChEMBL |
6.2 |
— |
— |
COc1cccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3cccc(OC)c3)c3ccccc23)c1 |
| E3 Binder |
CHEMBL4450274 |
ChEMBL |
6.0 |
— |
— |
COc1ccccc1/C=C/C(=O)c1ccc(OCCCN2CCCC2)cc1.Cl |
| E3 Binder |
CHEMBL4872820 |
ChEMBL |
6.71 |
— |
— |
CS(=O)(=O)Nc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(NS(C)(=O)=O)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4793109 |
ChEMBL |
6.75 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)CCCn2cc(nn2)CCNC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4778030 |
ChEMBL |
6.31 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4791554 |
ChEMBL |
8.51 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4747964 |
ChEMBL |
8.52 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4764193 |
ChEMBL |
8.47 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4740349 |
ChEMBL |
8.13 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)CCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL4243641 |
ChEMBL |
6.56 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL5176959 |
ChEMBL |
8.55 |
— |
— |
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc2ccc(cc2)OCCSC[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O |
| E3 Binder |
CHEMBL3423016 |
ChEMBL |
8.3 |
— |
— |
C[C@@H](O)[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O |
| E3 Binder |
CHEMBL4516372 |
ChEMBL |
7.51 |
— |
— |
C[C@@H](O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)C1CSCN1C(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NC(CC1CCCCC1)C(=O)O |
| E3 Binder |
CHEMBL3946551 |
ChEMBL |
7.02 |
— |
— |
C[C@@H](O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CCNC(=O)c1ccc(N=C=S)cc1C1c2ccc(O)cc2Oc2cc(O)ccc21)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| E3 Binder |
CHEMBL5283782 |
ChEMBL |
7.4 |
— |
— |
C[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)Cc2ccc(cc2)OCCSC[C@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC1=O |
| E3 Binder |
CHEMBL4160447 |
ChEMBL |
8.0 |
— |
— |
C[C@H](Oc1cccc(-c2cccc(-n3ncc(C(=O)O)c3[C@@H]3C[C@H]3c3cn(C)nn3)c2)c1)C1CCCCC1 |
| E3 Binder |
CHEMBL48802 |
ChEMBL |
6.06 |
— |
— |
C[S+]([O-])CCCCN=C=S |
| E3 Binder |
CHEMBL4542179 |
ChEMBL |
6.5 |
— |
— |
Cc1c(S(=O)(=O)N(C)Cc2cc(C(CC(=O)O)c3ccc4c(c3)nnn4C)ccc2Cl)cnn1C |
| E3 Binder |
CHEMBL3827630 |
ChEMBL |
6.7 |
— |
— |
Cc1c(S(=O)(=O)Nc2ccc(N3CC[C@@H](C(=O)O)C3)c3ccccc23)sc2ccc(Cl)cc12 |
| E3 Binder |
CHEMBL4865528 |
ChEMBL |
6.18 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(-c4nnn[nH]4)c3C3CC3)c2)c1C |
| E3 Binder |
CHEMBL4868608 |
ChEMBL |
6.14 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c1C |
| E3 Binder |
CHEMBL4856469 |
ChEMBL |
6.68 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3[C@H]3C[C@@H]3c3ccccc3)c2)c1C |
| E3 Binder |
CHEMBL4861607 |
ChEMBL |
6.43 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)N(CC(N)=O)c2cccc(-n3ncc(C(=O)O)c3[C@@H]3C[C@H]3c3ccccc3)c2)c1C |
| E3 Binder |
CHEMBL3827019 |
ChEMBL |
6.7 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc(N3CCC(C(=O)O)C3)c3ccccc23)c1C |
| E3 Binder |
CHEMBL3827626 |
ChEMBL |
7.0 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc(N3CC[C@@H](C(=O)O)C3)c3ccccc23)c1C |
| E3 Binder |
CHEMBL3827496 |
ChEMBL |
6.16 |
— |
— |
Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc(N3CC[C@@H](C(=O)O)C3)c3ncccc23)c1C |
| E3 Binder |
CHEMBL3899754 |
ChEMBL |
7.32 |
51M |
— |
Cc1cc(C)c(C)c(S(=O)(=O)Nc2ccc(N3CC[C@H](C(=O)O)C3)c3ccccc23)c1C |
| E3 Binder |
CHEMBL3601214 |
ChEMBL |
6.01 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3c(C)cc(C)cc3C)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4748547 |
ChEMBL |
6.37 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccc(Br)cc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4795421 |
ChEMBL |
6.72 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccc(Cl)cc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4793340 |
ChEMBL |
6.77 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccc(F)cc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4796980 |
ChEMBL |
6.8 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccc(O)cc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4777247 |
ChEMBL |
6.3 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccc(OC(C)C)cc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4747613 |
ChEMBL |
6.24 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2ccc(OC(C(=O)O)c3ccccc3)c3ccccc23)c(C)c1 |
| E3 Binder |
CHEMBL4847150 |
ChEMBL |
6.2 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3C3CC3)c2)c(C)c1 |
| E3 Binder |
CHEMBL4861831 |
ChEMBL |
7.01 |
— |
— |
Cc1cc(C)c(S(=O)(=O)N(CC(=O)O)c2cccc(-n3ncc(C(=O)O)c3[C@H]3C[C@@H]3c3ccccc3)c2)c(C)c1 |
| E3 Binder |
CHEMBL4473977 |
ChEMBL |
6.96 |
— |
— |
Cc1ccc(C(CC(=O)O)c2ccc3c(c2)nnn3C)cc1CN(C)S(=O)(=O)c1ccccc1 |
| E3 Binder |
CHEMBL5184245 |
ChEMBL |
7.85 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2cc(OCc3ccc(F)cc3)c(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL5197111 |
ChEMBL |
6.36 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c(OCc3ccc(-c4ccccc4)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5181633 |
ChEMBL |
6.35 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c(OCc3ccc(F)cc3)c2)cc1 |
| E3 Binder |
CHEMBL5206821 |
ChEMBL |
6.42 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c(OCc3ccc4ccccc4c3)c2)cc1 |
| E3 Binder |
CHEMBL5193997 |
ChEMBL |
6.35 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c(OCc3ccccc3)c2)cc1 |
| E3 Binder |
CHEMBL3601208 |
ChEMBL |
7.74 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL3601205 |
ChEMBL |
6.01 |
— |
— |
Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C)cc3)cc2)cc1 |
| E3 Binder |
CHEMBL3632704 |
ChEMBL |
6.05 |
— |
— |
Cc1ccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL1969108 |
ChEMBL |
6.94 |
— |
— |
Cc1ccc(S(=O)(=O)Oc2nc3nc4ccccc4nc3nc2OS(=O)(=O)c2ccc(C)cc2)cc1 |
| E3 Binder |
CHEMBL5284493 |
ChEMBL |
7.05 |
T6I |
— |
Cc1ccc([C@@H](NC(=O)[C@@H](F)c2ccc3c(c2)CCCC3)[C@@H](C)C(=O)O)cc1 |
| E3 Binder |
CHEMBL4875171 |
ChEMBL |
6.28 |
— |
— |
Cc1cccc(NS(C)(=O)=O)c1C |
| E3 Binder |
CHEMBL5208847 |
ChEMBL |
6.0 |
— |
— |
Cc1cccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3cccc(C)c3)c(OCc3ccccc3)c2)c1 |
| E3 Binder |
CHEMBL4167793 |
ChEMBL |
6.12 |
— |
— |
Cc1cccc2c1CCN(C(=O)[C@@H]1CCCC[C@@H]1C(=O)O)[C@@H]2CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL3890847 |
ChEMBL |
6.12 |
1VX |
— |
Cc1cccc2c1CCN(C(=O)[C@@H]1CCCC[C@@H]1C(=O)O)[C@@H]2CN1Cc2ccccc2C1=O |
| E3 Binder |
CHEMBL3422852 |
ChEMBL |
6.12 |
— |
— |
Cc1cccc2c1CCN(C(=O)[C@H]1CCCC[C@H]1C(=O)O)[C@@H]2CN1Cc2ccccc2C1=O |
| E3 Binder |
CHEMBL5075461 |
ChEMBL |
8.6 |
— |
— |
Cc1ccncc1N1CCOC2(C=C(C#N)C(=O)C(C)(C)C2)C1 |
| E3 Binder |
CHEMBL5077969 |
ChEMBL |
8.35 |
— |
— |
Cc1cncc(N2CCOC3(C=C(C#N)C(=O)C(C)(C)C3)C2)c1 |
| E3 Binder |
CHEMBL3827061 |
ChEMBL |
6.4 |
— |
— |
Cc1nc(-c2ccccc2)sc1S(=O)(=O)Nc1ccc(N2CC[C@@H](C(=O)O)C2)c2ccccc12 |
| E3 Binder |
CHEMBL4635896 |
ChEMBL |
7.25 |
— |
— |
Cn1nnc2cc(C(CC(=O)O)c3ccc4c(c3)CN(C(=O)c3ccccc3)CC4)ccc21 |
| E3 Binder |
CHEMBL3601220 |
ChEMBL |
6.93 |
— |
— |
N#Cc1ccc(S(=O)(=O)N(CC(=O)O)c2ccc(N(CC(=O)O)S(=O)(=O)c3ccc(C#N)cc3)c3ccccc23)cc1 |
| E3 Binder |
CHEMBL4860948 |
ChEMBL |
6.24 |
— |
— |
NC(=O)CN(c1cccc(-n2ncc(C(=O)O)c2C2CC2)c1)S(=O)(=O)c1ccccc1 |
| E3 Binder |
CHEMBL5287949 |
ChEMBL |
6.92 |
— |
— |
NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)O |
| E3 Binder |
CHEMBL5270467 |
ChEMBL |
7.0 |
— |
— |
N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
| E3 Binder |
CHEMBL4635873 |
ChEMBL |
6.24 |
— |
— |
O=C(O)CN(Cc1ccccc1CN(CC(=O)O)S(=O)(=O)c1ccc(OCc2ccccc2)cc1)S(=O)(=O)c1ccc(OCc2ccccc2)cc1 |
| E3 Binder |
CHEMBL4637517 |
ChEMBL |
6.38 |
— |
— |
O=C(O)CN(Cc1ccccc1CN(CC(=O)O)S(=O)(=O)c1ccc2oc3ccccc3c2c1)S(=O)(=O)c1ccc2oc3ccccc3c2c1 |
| E3 Binder |
CHEMBL4860663 |
ChEMBL |
8.05 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2cc3c(cc2Cl)OCCO3)c2ccccc12)S(=O)(=O)c1cc2c(cc1Cl)OCCO2 |
| E3 Binder |
CHEMBL5175042 |
ChEMBL |
6.12 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(-c3ccccc3)cc2)c(OCc2ccccc2)c1)S(=O)(=O)c1ccc(-c2ccccc2)cc1 |
| E3 Binder |
CHEMBL5189242 |
ChEMBL |
6.23 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(Br)cc2)c(OCc2ccccc2)c1)S(=O)(=O)c1ccc(Br)cc1 |
| E3 Binder |
CHEMBL3601211 |
ChEMBL |
7.44 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(Br)cc2)c2ccccc12)S(=O)(=O)c1ccc(Br)cc1 |
| E3 Binder |
CHEMBL3601218 |
ChEMBL |
6.91 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccccc12)S(=O)(=O)c1ccc(C(F)(F)F)cc1 |
| E3 Binder |
CHEMBL3601210 |
ChEMBL |
7.37 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(Cl)cc2)c2ccccc12)S(=O)(=O)c1ccc(Cl)cc1 |
| E3 Binder |
CHEMBL3601209 |
ChEMBL |
7.26 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(F)cc2)c2ccccc12)S(=O)(=O)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL4846463 |
ChEMBL |
7.94 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(N3C(=O)c4ccccc4C3=O)cc2)c2ccccc12)S(=O)(=O)c1ccc(N2C(=O)c3ccccc3C2=O)cc1 |
| E3 Binder |
CHEMBL4862491 |
ChEMBL |
6.9 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(NC(=O)C(F)(F)F)cc2)c2ccccc12)S(=O)(=O)c1ccc(NC(=O)C(F)(F)F)cc1 |
| E3 Binder |
CHEMBL3601216 |
ChEMBL |
6.75 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c2ccccc12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 |
| E3 Binder |
CHEMBL4851973 |
ChEMBL |
6.84 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc3c(c2)CCCO3)c2ccccc12)S(=O)(=O)c1ccc2c(c1)CCCO2 |
| E3 Binder |
CHEMBL4867904 |
ChEMBL |
6.79 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc3c(c2)CCO3)c2ccccc12)S(=O)(=O)c1ccc2c(c1)CCO2 |
| E3 Binder |
CHEMBL4853900 |
ChEMBL |
7.5 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc3c(c2)OCCO3)c2ccccc12)S(=O)(=O)c1ccc2c(c1)OCCO2 |
| E3 Binder |
CHEMBL4863099 |
ChEMBL |
6.83 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccc3c(c2)OCO3)c2ccccc12)S(=O)(=O)c1ccc2c(c1)OCO2 |
| E3 Binder |
CHEMBL3601217 |
ChEMBL |
7.32 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2cccc3ccccc23)c2ccccc12)S(=O)(=O)c1cccc2ccccc12 |
| E3 Binder |
CHEMBL3601215 |
ChEMBL |
7.46 |
— |
— |
O=C(O)CN(c1ccc(N(CC(=O)O)S(=O)(=O)c2ccccc2)c2ccccc12)S(=O)(=O)c1ccccc1 |
| E3 Binder |
CHEMBL4757005 |
ChEMBL |
6.11 |
— |
— |
O=C(O)CN(c1ccc(OC(C(=O)O)c2ccccc2)c2ccccc12)S(=O)(=O)c1cccc2ccccc12 |
| E3 Binder |
CHEMBL4847104 |
ChEMBL |
6.89 |
QH2 |
— |
O=C(O)CN(c1cccc(-n2ncc(C(=O)O)c2[C@H]2C[C@@H]2c2ccccc2)c1)S(=O)(=O)c1ccccc1 |
| E3 Binder |
CHEMBL4648175 |
ChEMBL |
6.37 |
— |
— |
O=C(O)CN(c1cnc(N(CC(=O)O)S(=O)(=O)c2ccc(F)cc2)c2ccccc12)S(=O)(=O)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL4641622 |
ChEMBL |
6.46 |
— |
— |
O=C(O)CN(c1cnc(N(CC(=O)O)S(=O)(=O)c2ccc(O)cc2)c2ccccc12)S(=O)(=O)c1ccc(O)cc1 |
| E3 Binder |
CHEMBL4645359 |
ChEMBL |
6.38 |
— |
— |
O=C(O)CN(c1ncc(N(CC(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c2ccccc12)S(=O)(=O)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL4634711 |
ChEMBL |
6.59 |
— |
— |
O=C(O)[C@H]1CCCC[C@H]1C(=O)N1CCc2c(C#CCO)cccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL4639381 |
ChEMBL |
7.01 |
— |
— |
O=C(O)[C@H]1CCCC[C@H]1C(=O)N1CCc2c(O)cccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL4636738 |
ChEMBL |
6.74 |
— |
— |
O=C(O)[C@H]1CCCC[C@H]1C(=O)N1CCc2c(OCCO)cccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL2381968 |
ChEMBL |
6.25 |
1VV |
— |
O=C(O)[C@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL5275178 |
ChEMBL |
7.01 |
— |
— |
O=C(O)[C@H]1CCC[C@H]1C(=O)N1CCc2c(O)cccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL4638389 |
ChEMBL |
6.06 |
— |
— |
O=C(O)[C@H]1CC[C@H]1C(=O)N1CCc2c(O)cccc2[C@H]1CN1C(=O)c2ccccc2C1=O |
| E3 Binder |
CHEMBL4208450 |
ChEMBL |
6.8 |
— |
— |
O=C(O)c1ccc(NC2=C/C(=N/S(=O)(=O)c3ccc4ccccc4c3)c3ccccc3C2=O)cc1 |
| E3 Binder |
CHEMBL5176162 |
ChEMBL |
6.92 |
— |
— |
O=C(O)c1cnn(-c2cccc(-c3cccc(C(=O)N4CCCCC4)c3F)c2)c1C1CC1 |
| E3 Binder |
CHEMBL5206413 |
ChEMBL |
6.52 |
— |
— |
O=C(O)c1cnn(-c2cccc([C@@H]3CCC[C@H](C(=O)N4CCCCC4)C3)c2)c1C1CC1 |
| E3 Binder |
CHEMBL3632706 |
ChEMBL |
6.18 |
— |
— |
O=S(=O)(Nc1ccc(NS(=O)(=O)c2ccc(F)cc2)c2ccccc12)c1ccc(F)cc1 |
| E3 Binder |
CHEMBL4876513 |
ChEMBL |
6.52 |
— |
— |
O=S(=O)(c1ccc(C(F)(F)F)cc1)N(Cc1nnn[nH]1)c1ccc(N(Cc2nnn[nH]2)S(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccccc12 |
| E3 Binder |
CHEMBL4865999 |
ChEMBL |
8.14 |
— |
— |
O=S(=O)(c1ccc2c(c1)OCCO2)N(Cc1nnn[nH]1)c1ccc(N(Cc2nnn[nH]2)S(=O)(=O)c2ccc3c(c2)OCCO3)c2ccccc12 |