TRI14

Details:

UniProt Entry: Q14142
Gene: TRIM14
Class: RING
Family: RING5
Protein length: 442
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6jbm

Protein Sequence ▾

>Q14142
MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL GAHRGHPVGL
ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL KANAESSKTW LKGKFTELRL
LLDEEEALAK KFIDKNTQLT LQVYREQADS CREQLDIMND LSNRVWSISQ EPDPVQRLQA
YTATEQEMQQ QMSLGELCHP VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS
DPSSTKPGTL LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV
PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS AAARLGCNRQ
SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG VLAFYDVTGG MSHLHTFRAT
FQEPLYPALR LWEGAISIPR LP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
19	61	Domain	B-box-type zinc finger	IPR000315	SM00336
22	58	Domain	B-box-type zinc finger	IPR000315	PF00643
24	58	Domain	B-box-type zinc finger	IPR000315	PS50119
249	442	Domain	B30.2/SPRY domain	IPR001870	PS50188
253	438	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
259	435	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
265	282	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
266	318	Domain	SPRY-associated	IPR006574	SM00589
269	441	Domain	TRIM14, PRY/SPRY domain	IPR044116	cd13738
270	317	Domain	SPRY-associated	IPR006574	PF13765
304	328	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
319	442	Domain	SPRY domain	IPR003877	SM00449
321	431	Domain	SPRY domain	IPR003877	PF00622
335	348	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
382	406	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
413	431	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006954	inflammatory response	Biological Process	IDA	PMID:21914792
GO:0071108	protein K48-linked deubiquitination	Biological Process	IMP	PMID:18162577
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005741	mitochondrial outer membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0045335	phagocytic vesicle	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0060090	molecular adaptor activity	Molecular Function	IDA	PMID:35145029
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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