KCNC3

Details:

UniProt Entry: Q14003
Gene: KCNC3
Class: Other E3 Components
Family: Adaptor
Protein length: 757
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q14003
MLSSVCVSSF RGRQGASKQQ PAPPPQPPES PPPPPLPPQQ QQPAQPGPAA SPAGPPAPRG
PGDRRAEPCP GLPAAAMGRH GGGGGDSGKI VINVGGVRHE TYRSTLRTLP GTRLAGLTEP
EAAARFDYDP GADEFFFDRH PGVFAYVLNY YRTGKLHCPA DVCGPLFEEE LGFWGIDETD
VEACCWMTYR QHRDAEEALD SFEAPDPAGA ANAANAAGAH DGGLDDEAGA GGGGLDGAGG
ELKRLCFQDA GGGAGGPPGG AGGAGGTWWR RWQPRVWALF EDPYSSRAAR YVAFASLFFI
LISITTFCLE THEGFIHISN KTVTQASPIP GAPPENITNV EVETEPFLTY VEGVCVVWFT
FEFLMRITFC PDKVEFLKSS LNIIDCVAIL PFYLEVGLSG LSSKAAKDVL GFLRVVRFVR
ILRIFKLTRH FVGLRVLGHT LRASTNEFLL LIIFLALGVL IFATMIYYAE RIGADPDDIL
GSNHTYFKNI PIGFWWAVVT MTTLGYGDMY PKTWSGMLVG ALCALAGVLT IAMPVPVIVN
NFGMYYSLAM AKQKLPKKKN KHIPRPPQPG SPNYCKPDPP PPPPPHPHHG SGGISPPPPI
TPPSMGVTVA GAYPAGPHTH PGLLRGGAGG LGIMGLPPLP APGEPCPLAQ EEVIEINRAD
PRPNGDPAAA ALAHEDCPAI DQPAMSPEDK SPITPGSRGR YSRDRACFLL TDYAPSPDGS
IRKATGAPPL PPQDWRKPGP PSFLPDLNAN AAAWISP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	18	Domain	Potassium channel, voltage dependent, Kv3, inactivation domain	IPR021105	PF11404
1	15	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582
59	73	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582
86	202	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
88	192	Domain	BTB/POZ domain	IPR000210	SM00225
88	192	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
90	184	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
134	144	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
135	148	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
150	165	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
168	189	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
214	227	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582
231	246	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582
266	430	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
280	292	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
290	547	Domain	Ion transport domain	IPR005821	PF00520
322	335	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582
423	431	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
447	461	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
527	538	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
552	566	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
577	593	Family	Potassium channel, voltage dependent, Kv3.3	IPR005404	PR01582

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0030866	cortical actin cytoskeleton organization	Biological Process	IDA	PMID:26997484
GO:0051262	protein tetramerization	Biological Process	IDA	PMID:23734863
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0042734	presynaptic membrane	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0032590	dendrite membrane	Cellular Component	IBA	GO_REF:0000033
GO:0032809	neuronal cell body membrane	Cellular Component	IBA	GO_REF:0000033
GO:0043679	axon terminus	Cellular Component	IBA	GO_REF:0000033
GO:0045211	postsynaptic membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005938	cell cortex	Cellular Component	IEA	GO_REF:0000044
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000044
GO:0030425	dendrite	Cellular Component	IEA	GO_REF:0000044
GO:0032591	dendritic spine membrane	Cellular Component	IEA	GO_REF:0000044
GO:0043204	perikaryon	Cellular Component	IEA	GO_REF:0000044
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0022836	gated channel activity	Molecular Function	IEA	GO_REF:0000117
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:26997484
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

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