CALI

Details:

UniProt Entry: Q13939
Gene: CCIN
Class: Other E3 Components
Family: Adaptor
Protein length: 588
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13939
MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN
DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC
NDFLIKSICR ANCLRYLFLA ELFELKEVSD VAYSGIRDNF HYWASPEGSM HFMRCPPVIF
GRLLRDENLH VLNEDQALSA LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL
VGMENTSSHT TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY
IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD
LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EVWCLAGKMS IPMDGTAVIT
KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT STGDVVQCIT FPIEFNHRPL LSFQQDNILC
VHSHRQSVEI NLQKVKASKT TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ
TKDYTINPNA FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	464	Family	BTB-kelch protein	IPR017096	PIRSF037037
1	128	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
6	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
18	127	Domain	BTB/POZ domain	IPR000210	PF00651
28	98	Domain	BTB/POZ domain	IPR000210	PS50097
28	128	Domain	BTB/POZ domain	IPR000210	SM00225
133	237	Domain	BTB/Kelch-associated	IPR011705	SM00875
133	234	Domain	BTB/Kelch-associated	IPR011705	PF07707
249	467	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
280	327	Repeat	Kelch repeat type 1	IPR006652	SM00612
281	577	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
328	375	Repeat	Kelch repeat type 1	IPR006652	SM00612
367	410	Repeat	Kelch repeat type 1	IPR006652	PF01344
376	423	Repeat	Kelch repeat type 1	IPR006652	SM00612
468	579	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
507	579	Family	BTB-kelch protein	IPR017096	PIRSF037037

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000120
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	HDA	PMID:21630459
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0033150	cytoskeletal calyx	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.