TF2H2

Details:

UniProt Entry: Q13888
Gene: GTF2H2
Class: RING
Family: RING1
Protein length: 395
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 1z60, 5ivw, 5iy6, 5iy7, 5iy8, 5iy9, 5o85, 5of4, 6nmi, 6o9l, 6o9m, 6ro4, 7ad8, 7egb, 7egc, 7ena, 7enc, 7lbm, 7nvr, 7nvw, 7nvx, 7nvy, 7nvz, 7nw0, 8gxq, 8gxs

Protein Sequence ▾

>Q13888
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL
SGNPRKHITS LKKAVDMTCH GEPSLYNSLS IAMQTLKHMP GHTSREVLII FSSLTTCDPS
NIYDLIKTLK AAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHVSPPP
ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG ELKDQHVYVC
AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	388	Family	TFIIH subunit Ssl1/p44	IPR012170	PIRSF015919
54	241	Homologous_superfamily	von Willebrand factor A-like domain superfamily	IPR036465	G3DSA:3.40.50.410
56	226	Homologous_superfamily	von Willebrand factor A-like domain superfamily	IPR036465	SSF53300
56	236	Domain	Ssl1-like	IPR007198	cd01453
58	233	Domain	von Willebrand factor, type A	IPR002035	SM00327
60	236	Domain	von Willebrand factor, type A	IPR002035	PS50234
64	255	Domain	Ssl1-like	IPR007198	PF04056
288	388	Family	TFIIH subunit Ssl1/p44	IPR012170	TIGR00622
323	385	Homologous_superfamily	C1-like domain superfamily	IPR046349	SSF57889
326	395	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
344	387	Domain	TFIIH C1-like domain	IPR004595	SM01047
345	385	Domain	TFIIH C1-like domain	IPR004595	PF07975
360	380	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002031	G protein-coupled receptor internalization	Biological Process	IMP	PMID:15775968
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000120
GO:0006289	nucleotide-excision repair	Biological Process	IEA	GO_REF:0000002
GO:0006351	DNA-templated transcription	Biological Process	IEA	GO_REF:0000002
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006366	transcription by RNA polymerase II	Biological Process	IDA	PMID:27193682
GO:0006367	transcription initiation at RNA polymerase II promoter	Biological Process	IDA	PMID:10924514
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0009411	response to UV	Biological Process	TAS	PMID:8194529
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-109639
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0000438	core TFIIH complex portion of holo TFIIH complex	Cellular Component	IDA	PMID:27193682
GO:0000439	transcription factor TFIIH core complex	Cellular Component	IEA	GO_REF:0000002
GO:0005669	transcription factor TFIID complex	Cellular Component	IDA	PMID:27193682
GO:0005675	transcription factor TFIIH holo complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:11445587
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016251	RNA polymerase II general transcription initiation factor activity	Molecular Function	IDA	PMID:10924514
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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