BACD2

Details:

UniProt Entry: Q13829
Gene: TNFAIP1
Class: Other E3 Components
Family: Adaptor
Protein length: 316
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13829
MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR
MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC
QSALQDKKDS YQPVCNIPII TSLKEEERLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL
KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE
FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEETFELRD RVRRIHVKRY
STYDDRQLGH QSTHRD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
23	279	Family	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1/2/3	IPR045068	PTHR11145
26	131	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
27	122	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
28	128	Domain	BTB/POZ domain	IPR000210	SM00225
28	96	Domain	BTB/POZ domain	IPR000210	PS50097
30	120	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0006915	apoptotic process	Biological Process	TAS	PMID:19637314
GO:0006955	immune response	Biological Process	IEP	PMID:1370465
GO:0016477	cell migration	Biological Process	IMP	PMID:19782033
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0035024	negative regulation of Rho protein signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0043149	stress fiber assembly	Biological Process	IMP	PMID:19782033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045740	positive regulation of DNA replication	Biological Process	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9696266
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19615732
GO:0030332	cyclin binding	Molecular Function	IEA	GO_REF:0000107
GO:0031267	small GTPase binding	Molecular Function	IDA	PMID:19637314
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956

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