RAPSN

Details:

UniProt Entry: Q13702
Gene: RAPSN
Class: RING
Family: RING9
Protein length: 412
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q13702
MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV TAHSEMGRYK
EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ
LGGQVSLSMG NAFLGLSVFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE
KALFFPCKAA ELVNNYGKGW SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG
DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK
ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE
LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	80	Domain	Rapsyn, myristoylation/linker region, N-terminal	IPR019568	PF10579
2	192	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
2	10	Conserved_site	43kDa postsynaptic, conserved site	IPR018293	PS00405
3	20	Family	43kDa postsynaptic protein	IPR001237	PR00217
6	39	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
10	167	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	SSF48452
24	42	Family	43kDa postsynaptic protein	IPR001237	PR00217
83	116	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
123	156	Repeat	Tetratricopeptide repeat	IPR019734	PS50005
123	156	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
128	334	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	SSF48452
139	320	Domain	MalT-like TPR region	IPR041617	PF17874
163	196	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
193	351	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
206	239	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
246	279	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
286	319	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
357	406	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
363	403	Domain	Zinc finger, RING-type	IPR001841	PS50089
363	403	Domain	Zinc finger, RING-type	IPR001841	PF13639
363	402	Domain	Zinc finger, RING-type	IPR001841	SM00184
377	392	Family	43kDa postsynaptic protein	IPR001237	PR00217
394	410	Family	43kDa postsynaptic protein	IPR001237	PR00217

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007268	chemical synaptic transmission	Biological Process	IEA	GO_REF:0000002
GO:0097049	motor neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:2000673	positive regulation of motor neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0007528	neuromuscular junction development	Biological Process	IEA	GO_REF:0000107
GO:0071340	skeletal muscle acetylcholine-gated channel clustering	Biological Process	IEA	GO_REF:0000107
GO:0098880	maintenance of postsynaptic specialization structure	Biological Process	IEA	GO_REF:0000108
GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Biological Process	IEA	GO_REF:0000107
GO:1900075	positive regulation of neuromuscular synaptic transmission	Biological Process	IEA	GO_REF:0000120
GO:1901626	regulation of postsynaptic membrane organization	Biological Process	IEA	GO_REF:0000120
GO:1903540	establishment of protein localization to postsynaptic membrane	Biological Process	IEA	GO_REF:0000120
GO:0007271	synaptic transmission, cholinergic	Biological Process	IGI	PMID:18420419
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000002
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0045211	postsynaptic membrane	Cellular Component	IEA	GO_REF:0000120
GO:0099634	postsynaptic specialization membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000107
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0031594	neuromuscular junction	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0033130	acetylcholine receptor binding	Molecular Function	IEA	GO_REF:0000002
GO:0043495	protein-membrane adaptor activity	Molecular Function	IEA	GO_REF:0000002
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IEA	GO_REF:0000107
GO:0035255	ionotropic glutamate receptor binding	Molecular Function	IEA	GO_REF:0000120
GO:0098879	structural constituent of postsynaptic specialization	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾

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