CUL4B

Details:

UniProt Entry: Q13620
Gene: CUL4B
Class: Other E3 Components
Family: Scaffold
Protein length: 913
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13620
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN
SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR
FEDTLEFVGF DAKMAEESSS SSSSSSPTAA TSQQQQLKNK SILISSVASV HHANGLAKSS
TTVSSFANSK PGSAKKLVIK NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL
YQAVENLCSY KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI LLLIERERNG
EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE GQKLMQEREV PEYLHHVNKR
LEEEADRLIT YLDQTTQKSL IATVEKQLLG EHLTAILQKG LNNLLDENRI QDLSLLYQLF
SRVRGGVQVL LQQWIEYIKA FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF
INAMKEAFET FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK DMELSKDIMI
QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE MVKLQEIFKT FYLGKHSGRK
LQWQSTLGHC VLKAEFKEGK KELQVSLFQT LVLLMFNEGE EFSLEEIKQA TGIEDGELRR
TLQSLACGKA RVLAKNPKGK DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE
RVFQDRQYQI DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME
RDKENPNQYN YIA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
209	555	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
210	909	Family	Cullin	IPR045093	PTHR11932
217	814	Domain	Cullin, N-terminal	IPR001373	PF00888
554	825	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
558	786	Domain	Cullin homology domain	IPR016158	PS50069
588	736	Domain	Cullin homology domain	IPR016158	SM00182
825	913	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
840	913	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
842	907	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
845	905	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
886	913	Conserved_site	Cullin, conserved site	IPR016157	PS01256

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0034644	cellular response to UV	Biological Process	IEA	GO_REF:0000117
GO:0042254	ribosome biogenesis	Biological Process	IEA	GO_REF:0000117
GO:0017038	protein import	Biological Process	IEA	GO_REF:0000002
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	NAS	PMID:8681378
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0048708	astrocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0070914	UV-damage excision repair	Biological Process	IDA	PMID:22334663
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000002
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IDA	PMID:16949367
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002
GO:0003684	damaged DNA binding	Molecular Function	IDA	PMID:22334663
GO:0005515	protein binding	Molecular Function	IPI	PMID:12609982

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