CUL4A

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
55	401	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
57	755	Family	Cullin	IPR045093	PTHR11932
63	660	Domain	Cullin, N-terminal	IPR001373	PF00888
400	671	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
404	632	Domain	Cullin homology domain	IPR016158	PS50069
434	582	Domain	Cullin homology domain	IPR016158	SM00182
671	759	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
686	759	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
688	753	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
691	751	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
732	759	Conserved_site	Cullin, conserved site	IPR016157	PS01256

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0034644	cellular response to UV	Biological Process	IEA	GO_REF:0000117
GO:0042254	ribosome biogenesis	Biological Process	IEA	GO_REF:0000117
GO:0008283	cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0007283	spermatogenesis	Biological Process	IDA	PMID:34065512
GO:0008284	positive regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0030097	hemopoiesis	Biological Process	IEA	GO_REF:0000107
GO:0030853	negative regulation of granulocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0035019	somatic stem cell population maintenance	Biological Process	IEA	GO_REF:0000107
GO:0035279	miRNA-mediated gene silencing by mRNA destabilization	Biological Process	IDA	PMID:16289642
GO:0042110	T cell activation	Biological Process	IDA	PMID:34065512
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0045732	positive regulation of protein catabolic process	Biological Process	IDA	PMID:11027288
GO:0051246	regulation of protein metabolic process	Biological Process	IEA	GO_REF:0000120
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	IMP	PMID:23391734
GO:0097510	base-excision repair, AP site formation via deaminated base removal	Biological Process	IDA	PMID:18973764
GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	Biological Process	IDA	PMID:29779948
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:2000001	regulation of DNA damage checkpoint	Biological Process	IEA	GO_REF:0000107
GO:2000819	regulation of nucleotide-excision repair	Biological Process	IEA	GO_REF:0000107
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	TAS	PMID:8681378
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0032502	developmental process	Biological Process	IEA	GO_REF:0000117
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	TAS	PMID:8681378
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-5652005
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IDA	PMID:16949367
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:12504025
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:20870715
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:34065512

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4475993	ChEMBL	6.33	—	—	CC(=O)CN1C(=O)C(=O)c2cc(Br)ccc21
E3 Binder	CHEMBL4585473	ChEMBL	6.85	—	—	CCOC(=O)Oc1c(Cl)cc2oc(=O)sc2c1Cl
E3 Binder	CHEMBL4462527	ChEMBL	6.72	—	—	CCOC(=O)Oc1cc2oc(=O)sc2cc1Cl
E3 Binder	CHEMBL4444266	ChEMBL	6.63	—	—	COC(=O)Oc1cc2oc(=O)sc2cc1Cl
E3 Binder	CHEMBL1540912	ChEMBL	6.0	—	—	COc1ccc(-c2c(C#N)c(S)nc3c2CCC3)cc1
E3 Binder	CHEMBL4592960	ChEMBL	6.13	—	—	COc1ccc(-c2c3c([nH]c(=S)c2C#N)CCCC3)cc1
E3 Binder	CHEMBL4442009	ChEMBL	6.03	—	—	Clc1ccc2nc(Cl)c3nnnn3c2c1
E3 Binder	CHEMBL4539276	ChEMBL	6.94	—	—	N#Cc1c(-c2ccc(O)cc2)c2c([nH]c1=S)CCCC2
E3 Binder	CHEMBL1532407	ChEMBL	6.26	—	—	N#Cc1c(S)nc2c(c1-c1ccco1)CCCC2

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CUL4A

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾