CUL3

>Q13618
MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN
AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR
DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR
GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR
INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLGCMY
KLFSRVPNGL KTMCECMSSY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLLESF
NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR
FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS
NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL
AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT
ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIENGHIFT
VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN
VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
27	764	Family	Cullin	IPR045093	PTHR11932
31	385	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
34	665	Domain	Cullin, N-terminal	IPR001373	PF00888
377	675	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
383	635	Domain	Cullin homology domain	IPR016158	PS50069
413	563	Domain	Cullin homology domain	IPR016158	SM00182
680	768	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
682	764	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
695	762	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
698	760	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
741	768	Conserved_site	Cullin, conserved site	IPR016157	PS01256

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000278	mitotic cell cycle	Biological Process	IEA	GO_REF:0000120
GO:0000902	cell morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0001831	trophectodermal cellular morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006366	transcription by RNA polymerase II	Biological Process	IDA	PMID:9852112
GO:0006368	transcription elongation by RNA polymerase II	Biological Process	IDA	PMID:9852112
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Biological Process	IDA	PMID:35989311
GO:0006979	response to oxidative stress	Biological Process	IDA	PMID:36075446
GO:0007369	gastrulation	Biological Process	IEA	GO_REF:0000107
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IDA	PMID:10500095
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:31601708
GO:0032480	negative regulation of type I interferon production	Biological Process	IDA	PMID:36394357
GO:0032481	positive regulation of type I interferon production	Biological Process	IDA	PMID:17404045
GO:0032869	cellular response to insulin stimulus	Biological Process	IDA	PMID:27708159
GO:0034198	cellular response to amino acid starvation	Biological Process	IDA	PMID:35338845
GO:0034599	cellular response to oxidative stress	Biological Process	IDA	PMID:15601839
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0044346	fibroblast apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	IMP	PMID:23391734
GO:0070294	renal sodium ion absorption	Biological Process	ISS	PMID:14608358
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:27708159
GO:0071230	cellular response to amino acid stimulus	Biological Process	IDA	PMID:29769719
GO:0072576	liver morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0160240	RNA polymerase II transcription initiation surveillance	Biological Process	IDA	PMID:39504960
GO:1900076	regulation of cellular response to insulin stimulus	Biological Process	IC	PMID:27708159
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:35338845
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:29769719
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	TAS	PMID:8681378
GO:0001822	kidney development	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:22358839
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Biological Process	IDA	PMID:22358839
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000117
GO:0006950	response to stress	Biological Process	IEA	GO_REF:0000117
GO:0006954	inflammatory response	Biological Process	IEA	GO_REF:0000107
GO:0007080	mitotic metaphase chromosome alignment	Biological Process	IMP	PMID:17543862
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0007229	integrin-mediated signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0008284	positive regulation of cell population proliferation	Biological Process	TAS	PMID:9733711
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0010558	negative regulation of macromolecule biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000043
GO:0016477	cell migration	Biological Process	IMP	PMID:19782033
GO:0017145	stem cell division	Biological Process	ISS	GO_REF:0000024
GO:0030030	cell projection organization	Biological Process	IEA	GO_REF:0000043
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IGI	PMID:24844779
GO:0031648	protein destabilization	Biological Process	IGI	PMID:24844779
GO:0032467	positive regulation of cytokinesis	Biological Process	IMP	PMID:19261606
GO:0035024	negative regulation of Rho protein signal transduction	Biological Process	IMP	PMID:19782033
GO:0040016	embryonic cleavage	Biological Process	ISS	GO_REF:0000024
GO:0043149	stress fiber assembly	Biological Process	IMP	PMID:19782033
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	Biological Process	IMP	PMID:17543862
GO:0048208	COPII vesicle coating	Biological Process	IMP	PMID:22358839
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:14528312
GO:0071630	nuclear protein quality control by the ubiquitin-proteasome system	Biological Process	IDA	PMID:27561354
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	TAS	PMID:8681378
GO:0140252	regulation protein catabolic process at postsynapse	Biological Process	IEA	GO_REF:0000107
GO:1901992	positive regulation of mitotic cell cycle phase transition	Biological Process	IMP	PMID:23213400
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:27708159
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0000922	spindle pole	Cellular Component	IEA	GO_REF:0000044
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-5635854
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005827	polar microtubule	Cellular Component	IDA	PMID:19995937
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1504190
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:19617556
GO:0005929	cilium	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	HDA	PMID:19946888
GO:0031514	motile cilium	Cellular Component	IEA	GO_REF:0000120
GO:0036126	sperm flagellum	Cellular Component	IDA	PMID:28395323
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0072686	mitotic spindle	Cellular Component	IDA	PMID:23213400
GO:0098794	postsynapse	Cellular Component	IEA	GO_REF:0000108
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15983046
GO:0005112	Notch binding	Molecular Function	IPI	PMID:25401743
GO:0005515	protein binding	Molecular Function	IPI	PMID:12609982
GO:0030332	cyclin binding	Molecular Function	IEA	GO_REF:0000107
GO:0031208	POZ domain binding	Molecular Function	IDA	PMID:14528312
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000107
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:14528312
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:15601839