CUL2

Details:

UniProt Entry: Q13617
Gene: CUL2
Class: Other E3 Components
Family: Scaffold
Protein length: 745
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13617
MSLKPRVVDF DETWNKLLTT IKAVVMLEYV ERATWNDRFS DIYALCVAYP EPLGERLYTE
TKIFLENHVR HLHKRVLESE EQVLVMYHRY WEEYSKGADY MDCLYRYLNT QFIKKNKLTE
ADLQYGYGGV DMNEPLMEIG ELALDMWRKL MVEPLQAILI RMLLREIKND RGGEDPNQKV
IHGVINSFVH VEQYKKKFPL KFYQEIFESP FLTETGEYYK QEASNLLQES NCSQYMEKVL
GRLKDEEIRC RKYLHPSSYT KVIHECQQRM VADHLQFLHA ECHNIIRQEK KNDMANMYVL
LRAVSTGLPH MIQELQNHIH DEGLRATSNL TQENMPTLFV ESVLEVHGKF VQLINTVLNG
DQHFMSALDK ALTSVVNYRE PKSVCKAPEL LAKYCDNLLK KSAKGMTENE VEDRLTSFIT
VFKYIDDKDV FQKFYARMLA KRLIHGLSMS MDSEEAMINK LKQACGYEFT SKLHRMYTDM
SVSADLNNKF NNFIKNQDTV IDLGISFQIY VLQAGAWPLT QAPSSTFAIP QELEKSVQMF
ELFYSQHFSG RKLTWLHYLC TGEVKMNYLG KPYVAMVTTY QMAVLLAFNN SETVSYKELQ
DSTQMNEKEL TKTIKSLLDV KMINHDSEKE DIDAESSFSL NMNFSSKRTK FKITTSMQKD
TPQEMEQTRS AVDEDRKMYL QAAIVRIMKA RKVLRHNALI QEVISQSRAR FNPSISMIKK
CIEVLIDKQY IERSQASADE YSYVA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	380	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
11	745	Family	Cullin	IPR045093	PTHR11932
14	644	Domain	Cullin, N-terminal	IPR001373	PF00888
382	654	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
386	618	Domain	Cullin homology domain	IPR016158	PS50069
416	568	Domain	Cullin homology domain	IPR016158	SM00182
657	745	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
657	745	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
672	739	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
675	735	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
718	745	Conserved_site	Cullin, conserved site	IPR016157	PS01256

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000117
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0140627	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	Biological Process	IDA	PMID:29779948
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031981	nuclear lumen	Cellular Component	IEA	GO_REF:0000117
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0031462	Cul2-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1234159
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000120
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	TAS	Reactome:R-HSA-8956106
GO:0005515	protein binding	Molecular Function	IPI	PMID:12504026
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033

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