CUL1

Details:

UniProt Entry: Q13616
Gene: CUL1
Class: Other E3 Components
Family: Scaffold
Protein length: 776
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13616
MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT
QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT
NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT
ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL
NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE
LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA
SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL
SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT
LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE
VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK
MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
16	776	Family	Cullin	IPR045093	PTHR11932
17	409	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
21	658	Domain	Cullin, N-terminal	IPR001373	PF00888
413	686	Homologous_superfamily	Cullin homology domain superfamily	IPR036317	SSF75632
417	644	Domain	Cullin homology domain	IPR016158	PS50069
447	594	Domain	Cullin homology domain	IPR016158	SM00182
604	671	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
672	776	Homologous_superfamily	Winged helix-like DNA-binding domain superfamily	IPR036388	G3DSA:1.10.10.10
687	776	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
703	770	Domain	Cullin protein, neddylation domain	IPR019559	SM00884
706	766	Domain	Cullin protein, neddylation domain	IPR019559	PF10557
749	776	Conserved_site	Cullin, conserved site	IPR016157	PS01256

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0008283	cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0009887	animal organ morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000117
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0010498	proteasomal protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0000045	autophagosome assembly	Biological Process	IDA	PMID:28890335
GO:0007040	lysosome organization	Biological Process	IDA	PMID:24448649
GO:0010507	negative regulation of autophagy	Biological Process	IDA	PMID:32561715
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:22017875
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:32561715
GO:0034599	cellular response to oxidative stress	Biological Process	IDA	PMID:39880951
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:12087098
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:10644755
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:25038658
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:10230407
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:19008854
GO:1904037	positive regulation of epithelial cell apoptotic process	Biological Process	IDA	PMID:34480022
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:22017875
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000120
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0005634	nucleus	Cellular Component	IC	PMID:15145941
GO:0005737	cytoplasm	Cellular Component	IC	PMID:11961546
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-1363328
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1168642
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:19617556
GO:1990452	Parkin-FBXW7-Cul1 ubiquitin ligase complex	Cellular Component	IPI	PMID:12628165
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000120
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:11961546
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033

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