SQSTM

>Q13501
MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN
MVHPNVICDG CNGPVVGTRY KCSVCPDYDL CSVCEGKGLH RGHTKLAFPS PFGHLSEGFS
HSRWLRKVKH GHFGWPGWEM GPPGNWSPRP PRAGEARPGP TAESASGPSE DPSVNFLKNV
GESVAAALSP LGIEVDIDVE HGGKRSRLTP VSPESSSTEE KSSSQPSSCC SDPSKPGGNV
EGATQSLAEQ MRKIALESEG RPEEQMESDN CSGGDDDWTH LSSKEVDPST GELQSLQMPE
SEGPSSLDPS QEGPTGLKEA ALYPHLPPEA DPRLIESLSQ MLSMGFSDEG GWLTRLLQTK
NYDIGAALDT IQYSKHPPPL

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
3	102	Domain	PB1 domain	IPR000270	SM00666
3	102	Domain	PB1 domain	IPR000270	PS51745
4	102	Domain	Sequestosome-1, PB1 domain	IPR034866	cd06402
41	100	Domain	PB1 domain	IPR000270	PF00564
116	168	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
122	165	Domain	Zinc finger, ZZ-type	IPR000433	SM00291
123	173	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
123	159	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
128	154	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
379	440	Domain	Sequestosome-1, UBA domain	IPR033741	PF16577
387	436	Homologous_superfamily	UBA-like superfamily	IPR009060	SSF46934
389	434	Domain	Ubiquitin-associated domain	IPR015940	PS50030
393	432	Domain	Sequestosome-1, UBA domain	IPR033741	cd14320
394	433	Domain	Ubiquitin-associated domain	IPR015940	SM00165

GO term	Name	Ontology	Evidence	Reference
GO:0006366	transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:15572695
GO:0030163	protein catabolic process	Biological Process	IDA	PMID:36221902
GO:0033554	cellular response to stress	Biological Process	IDA	PMID:37802024
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:25371197
GO:0035973	aggrephagy	Biological Process	IDA	PMID:17580304
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:33799071
GO:0071211	protein targeting to vacuole involved in autophagy	Biological Process	IDA	PMID:37802024
GO:0000422	autophagy of mitochondrion	Biological Process	NAS	PMID:20098416
GO:0000423	mitophagy	Biological Process	IBA	GO_REF:0000033
GO:0000425	pexophagy	Biological Process	IDA	PMID:26344566
GO:0001659	temperature homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0002931	response to ischemia	Biological Process	IEA	GO_REF:0000107
GO:0006606	protein import into nucleus	Biological Process	IEA	GO_REF:0000107
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000120
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007032	endosome organization	Biological Process	IBA	GO_REF:0000033
GO:0008104	protein localization	Biological Process	TAS	PMID:8650207
GO:0010508	positive regulation of autophagy	Biological Process	IDA	PMID:28871090
GO:0010821	regulation of mitochondrion organization	Biological Process	NAS	PMID:20890124
GO:0016197	endosomal transport	Biological Process	TAS	PMID:12857745
GO:0016236	macroautophagy	Biological Process	ISS	GO_REF:0000024
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:31281713
GO:0035556	intracellular signal transduction	Biological Process	TAS	PMID:8650207
GO:0043065	positive regulation of apoptotic process	Biological Process	TAS	Reactome:R-HSA-205043
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IMP	PMID:12857745
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:12857745
GO:0046578	regulation of Ras protein signal transduction	Biological Process	NAS	PMID:8618896
GO:0061635	regulation of protein complex stability	Biological Process	IDA	PMID:25127057
GO:0070342	brown fat cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0097009	energy homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0098780	response to mitochondrial depolarisation	Biological Process	IGI	PMID:20457763
GO:0110076	negative regulation of ferroptosis	Biological Process	IMP	PMID:26403645
GO:0140694	membraneless organelle assembly	Biological Process	IEA	GO_REF:0000107
GO:1900273	positive regulation of long-term synaptic potentiation	Biological Process	ISS	GO_REF:0000024
GO:1903078	positive regulation of protein localization to plasma membrane	Biological Process	ISS	GO_REF:0000024
GO:1905719	protein localization to perinuclear region of cytoplasm	Biological Process	IDA	PMID:27368102
GO:0005776	autophagosome	Cellular Component	IEA	GO_REF:0000044
GO:0030017	sarcomere	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IC	PMID:31281713
GO:0005829	cytosol	Cellular Component	IDA	PMID:8650207
GO:0016235	aggresome	Cellular Component	IBA	GO_REF:0000033
GO:0043232	intracellular membraneless organelle	Cellular Component	IEA	GO_REF:0000107
GO:0044753	amphisome	Cellular Component	IBA	GO_REF:0000033
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0000407	phagophore assembly site	Cellular Component	IEA	GO_REF:0000120
GO:0000932	P-body	Cellular Component	IDA	PMID:20357094
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-204947
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000107
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005770	late endosome	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0016234	inclusion body	Cellular Component	IEA	GO_REF:0000117
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0044754	autolysosome	Cellular Component	IEA	GO_REF:0000107
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0097225	sperm midpiece	Cellular Component	IEA	GO_REF:0000107
GO:0097413	Lewy body	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005080	protein kinase C binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:14676191
GO:0019899	enzyme binding	Molecular Function	IPI	PMID:27368102
GO:0019901	protein kinase binding	Molecular Function	IDA	PMID:8650207
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IEA	GO_REF:0000107
GO:0030971	receptor tyrosine kinase binding	Molecular Function	TAS	PMID:8650207
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:25127057
GO:0035255	ionotropic glutamate receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0035591	signaling adaptor activity	Molecular Function	IDA	PMID:27498865
GO:0038023	signaling receptor activity	Molecular Function	IDA	PMID:28871090
GO:0042169	SH2 domain binding	Molecular Function	IDA	PMID:8650207
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000120
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:12857745
GO:0044877	protein-containing complex binding	Molecular Function	IEA	GO_REF:0000107
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IBA	GO_REF:0000033
GO:0140036	ubiquitin-modified protein reader activity	Molecular Function	IEA	GO_REF:0000107
GO:0140311	protein sequestering activity	Molecular Function	IDA	PMID:37306101
GO:0140313	molecular sequestering activity	Molecular Function	IDA	PMID:31281713
GO:0140693	molecular condensate scaffold activity	Molecular Function	IEA	GO_REF:0000107

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P00338	LDHA	Yes	No	No	No	—	No	E3-specific

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3906697	ChEMBL	6.64	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(CC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL3928944	ChEMBL	6.72	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(CCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL3962296	ChEMBL	6.82	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(CCCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL3925906	ChEMBL	6.75	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(SCC(=O)O)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL3953535	ChEMBL	6.43	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(SCC(=O)OC)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL3934789	ChEMBL	6.0	—	—	CCOc1ccc(S(=O)(=O)Nc2cc(Sc3nc[nH]n3)c(NS(=O)(=O)c3ccc(OCC)cc3)c3ccccc23)cc1
E3 Binder	CHEMBL2402207	ChEMBL	6.04	IQK	—	COc1ccc(S(=O)(=O)Nc2ccc(NS(=O)(=O)c3ccc(OC)cc3)c3ccccc23)cc1