BIRC2

>Q13490
MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR
KCPICRGIIK GTVRTFLS

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
44	115	Repeat	BIR repeat	IPR001370	SM00238
46	113	Repeat	BIR repeat	IPR001370	PS01282
49	115	Repeat	BIR repeat	IPR001370	cd00022
49	114	Repeat	BIR repeat	IPR001370	PF00653
49	114	Repeat	BIR repeat	IPR001370	PS50143
182	252	Repeat	BIR repeat	IPR001370	SM00238
184	250	Repeat	BIR repeat	IPR001370	PS01282
185	252	Repeat	BIR repeat	IPR001370	cd00022
187	250	Repeat	BIR repeat	IPR001370	PF00653
187	251	Repeat	BIR repeat	IPR001370	PS50143
267	338	Repeat	BIR repeat	IPR001370	SM00238
269	336	Repeat	BIR repeat	IPR001370	PS01282
270	336	Repeat	BIR repeat	IPR001370	cd00022
272	337	Repeat	BIR repeat	IPR001370	PS50143
272	336	Repeat	BIR repeat	IPR001370	PF00653
391	437	Domain	BIRC2/BIRC3, UBA domain	IPR041933	cd14394
452	579	Homologous_superfamily	Death-like domain superfamily	IPR011029	G3DSA:1.10.533.10
453	541	Domain	CARD domain	IPR001315	SM00114
453	551	Homologous_superfamily	Death-like domain superfamily	IPR011029	SSF47986
453	543	Domain	CARD domain	IPR001315	PS50209
459	540	Domain	CARD domain	IPR001315	PF00619
571	605	Domain	Zinc finger, RING-type	IPR001841	SM00184
571	606	Domain	Zinc finger, RING-type	IPR001841	PS50089

GO term	Name	Ontology	Evidence	Reference
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:1902531	regulation of intracellular signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0034121	regulation of toll-like receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0039535	regulation of RIG-I signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0050727	regulation of inflammatory response	Biological Process	IEA	GO_REF:0000117
GO:0060544	regulation of necroptotic process	Biological Process	IEA	GO_REF:0000117
GO:0070424	regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0001890	placenta development	Biological Process	IEA	GO_REF:0000107
GO:0060546	negative regulation of necroptotic process	Biological Process	IEA	GO_REF:0000107
GO:0071356	cellular response to tumor necrosis factor	Biological Process	IEA	GO_REF:0000107
GO:1901222	regulation of non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:1902443	negative regulation of ripoptosome assembly involved in necroptotic process	Biological Process	IEA	GO_REF:0000107
GO:1902916	positive regulation of protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:2000377	regulation of reactive oxygen species metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:11907583
GO:0001666	response to hypoxia	Biological Process	IEA	GO_REF:0000120
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS	PMID:8548810
GO:0042127	regulation of cell population proliferation	Biological Process	TAS	PMID:18414036
GO:0043066	negative regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:11907583
GO:0045088	regulation of innate immune response	Biological Process	TAS	PMID:21447281
GO:0045471	response to ethanol	Biological Process	IEA	GO_REF:0000120
GO:0045595	regulation of cell differentiation	Biological Process	TAS	PMID:18414036
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0051591	response to cAMP	Biological Process	IEA	GO_REF:0000120
GO:0051726	regulation of cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0070266	necroptotic process	Biological Process	IEA	GO_REF:0000107
GO:1902523	positive regulation of protein K63-linked ubiquitination	Biological Process	IDA	PMID:21931591
GO:1902524	positive regulation of protein K48-linked ubiquitination	Biological Process	IDA	PMID:21931591
GO:1902527	positive regulation of protein monoubiquitination	Biological Process	IDA	PMID:21931591
GO:1904975	response to bleomycin	Biological Process	IEA	GO_REF:0000120
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0001741	XY body	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-168915
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	ISS	GO_REF:0000024
GO:0032991	protein-containing complex	Cellular Component	IEA	GO_REF:0000120
GO:0035631	CD40 receptor complex	Cellular Component	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0003713	transcription coactivator activity	Molecular Function	IMP	PMID:21653699
GO:0005515	protein binding	Molecular Function	IPI	PMID:11084335
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22493164
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Molecular Function	IBA	GO_REF:0000033
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:16510124
GO:0044877	protein-containing complex binding	Molecular Function	IEA	GO_REF:0000120
GO:0051087	protein-folding chaperone binding	Molecular Function	IPI	PMID:18239673
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0098770	FBXO family protein binding	Molecular Function	IPI	PMID:16510124

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8NBP7	PCSK9	Yes	Yes	No	No	—	No	E3-specific
Q86VP3	PACS2	Yes	Yes	No	No	—	No	Cluster-specific
P42574	CASP3	Yes	Yes	No	No	11084335	EBI-524076	Cluster-specific
Q9Y6D9	MD1L1	Yes	Yes	No	No	—	No	E3-specific
P55210	CASP7	Yes	Yes	Yes	No	11084335	EBI-523986	Cluster-specific
P55060	XPO2	Yes	Yes	No	No	—	No	E3-specific
P57078	RIPK4	Yes	Yes	Yes	No	21931591	EBI-4422352	Cluster-specific
Q96HS1	PGAM5	Yes	Yes	No	No	—	No	Cluster-specific

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3236383	ChEMBL	6.7	—	—	C#CCOCC(C(=O)N1CC[C@@H]2C[C@@H]3CCC[C@H](NC(=O)[C@H](C)NC)C(=O)N3[C@@H]2C1)c1ccccc1
E3 Binder	CHEMBL3108923	ChEMBL	8.4	—	—	C#CCO[C@@H]1CCc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C
E3 Binder	CHEMBL3108925	ChEMBL	8.0	—	—	C#CCO[C@H]1CCc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C
E3 Binder	CHEMBL3108924	ChEMBL	7.4	—	—	C#CCO[C@H]1CCc2ccccc2[C@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C
E3 Binder	CHEMBL3699974	ChEMBL	7.23	—	—	C=C(c1ccccc1)c1cc2c(cn1)C(C)(C)CN2C(=O)CN1C[C@@H](C)NC[C@@H]1COC
E3 Binder	CHEMBL3700079	ChEMBL	7.66	—	—	CC(C)C(F)(F)c1cc2c(cn1)C(C)(C)CN2C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCCC1=O
E3 Binder	CHEMBL3700094	ChEMBL	7.68	—	—	CC(C)CC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCOCC1)CC2(C)C
E3 Binder	CHEMBL5186855	ChEMBL	6.82	—	—	CC(C)[C@H](NC(=O)[C@H](C)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4173890	ChEMBL	8.42	—	—	CC1=C(C)C(=O)N(C[C@H]2CN[C@H](C)CN2CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)C1
E3 Binder	CHEMBL3700081	ChEMBL	7.62	—	—	CCC(F)(F)c1cc2c(cn1)C(C)(C)CN2C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CC[C@@H](F)C1
E3 Binder	CHEMBL3700061	ChEMBL	7.54	—	—	CCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCCC1=O)CC2(C)C
E3 Binder	CHEMBL3700106	ChEMBL	7.62	—	—	CCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCOC[C@H]1COC)CC2(C)C
E3 Binder	CHEMBL3700014	ChEMBL	7.1	—	—	CCC1(CC)CN(C(=O)CN2C[C@@H](C)NC[C@@H]2C(=O)N2CCOCC2)c2cc(Cl)ccc21
E3 Binder	CHEMBL4111272	ChEMBL	6.3	—	—	CCC1(CC)Oc2nc(NC(=O)[C@@H](C)NC)ccc2N(c2ccc(Cl)cc2)C1=O
E3 Binder	CHEMBL3893895	ChEMBL	6.3	—	—	CCC1(CC)Oc2nc(NC(=O)[C@H](C)N)ccc2N(c2ccc(Cl)cc2)C1=O
E3 Binder	CHEMBL4090609	ChEMBL	7.62	—	—	CCCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCCC1=O)CC2(C)C
E3 Binder	CHEMBL4518625	ChEMBL	8.89	—	—	CCO[C@@H]1C[C@@H]2CN(C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCC(F)(F)CC3)[C@H](C(=O)N[C@H]3CCOc4ccccc43)CN2C1
E3 Binder	CHEMBL3699946	ChEMBL	6.3	—	—	CCS(=O)(=O)c1ccc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1COC)CC2(C)C
E3 Binder	CHEMBL3700104	ChEMBL	7.77	—	—	CC[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(C(C)(F)F)cc21
E3 Binder	CHEMBL234346	ChEMBL	9.49	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)O
E3 Binder	CHEMBL365059	ChEMBL	6.73	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(N)=O
E3 Binder	CHEMBL3039522	ChEMBL	9.0	GT6	—	CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c(-c2[nH]c3cc(F)ccc3c2C[C@@H]2C[C@H](O)CN2C(=O)[C@H](CC)NC(=O)[C@H](C)NC)[nH]c2cc(F)ccc12
E3 Binder	CHEMBL2204567	ChEMBL	8.82	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CCNC(=O)CCc1cn(CCOCCOCCOCCNC(=O)[C@@H](NC(=O)[C@@H]3CC[C@@H]4CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N43)c3ccccc3)nn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL1957022	ChEMBL	8.59	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CCNCc1cc(Cl)cc(Cl)c1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL1957025	ChEMBL	8.48	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CCNCc1ccc(C(C)(C)C)cc1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL2204574	ChEMBL	8.85	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCCC#CC#CCCCC(=O)NC[C@H]1CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@H]1NC(=O)[C@H](CC)NC)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204578	ChEMBL	8.42	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCCCC#CC#CCCCCCC(=O)NC[C@H]1CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@H]1NC(=O)[C@H](CC)NC)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204575	ChEMBL	8.85	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCCCCCCCC(=O)NC[C@H]1CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@H]1NC(=O)[C@H](CC)NC)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204579	ChEMBL	8.46	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCCCc1cn(CCCCc3ccc(CCCCn4cc(CCCCC(=O)NC[C@H]5CC[C@H]6CC[C@@H](C(=O)NC(c7ccccc7)c7ccccc7)N6C(=O)[C@H]5NC(=O)[C@H](CC)NC)nn4)cc3)nn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204573	ChEMBL	8.54	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCc1cn(C[C@H]3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@H]3NC(=O)[C@H](CC)NC)nn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204569	ChEMBL	8.49	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)COCC(=O)NCCOCCOCCOCCNC(=O)[C@@H](NC(=O)[C@@H]1CC[C@@H]3CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N31)c1ccccc1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204576	ChEMBL	8.77	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)COCCOCCOCC(=O)NC[C@H]1CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@H]1NC(=O)[C@H](CC)NC)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL4098982	ChEMBL	8.96	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)c1ccccc1)CC[C@H]2C(=O)N[C@H](C(=O)NCCN(Cc1ccccn1)Cc1ccccn1)c1ccccc1
E3 Binder	CHEMBL2204572	ChEMBL	8.77	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)c1cn(C[C@H]3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@H]3NC(=O)[C@H](CC)NC)nn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2205249	ChEMBL	7.75	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNCc1ccccc1)CC[C@H]2C(=O)N[C@@H](c1ccccc1)c1cn(CCCCc2ccc(CCCCn3cc([C@@H](NC(=O)[C@@H]4CC[C@@H]5CC[C@H](CNCc6ccccc6)[C@H](NC(=O)[C@H](CC)NC)C(=O)N54)c4ccccc4)nn3)cc2)nn1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204581	ChEMBL	8.27	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CO)CC[C@H]2C(=O)N[C@@H](c1ccccc1)c1cn(CCCCc2ccc(CCCCn3cc([C@@H](NC(=O)[C@@H]4CC[C@@H]5CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N54)c4ccccc4)nn3)cc2)nn1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204582	ChEMBL	8.72	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CO)CC[C@H]2C(=O)N[C@H](C(=O)NCCCCCCCCNC(=O)[C@@H](NC(=O)[C@@H]1CC[C@@H]2CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N21)c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2205247	ChEMBL	8.59	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CO)CC[C@H]2C(=O)N[C@H](C(=O)NCCCCCNc1c(NCCCCCNC(=O)[C@@H](NC(=O)[C@@H]2CC[C@@H]3CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N32)c2ccccc2)c(=O)c1=O)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2205246	ChEMBL	8.82	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CO)CC[C@H]2C(=O)N[C@H](C(=O)NCCCOCCOCCOCCCNC(=O)[C@@H](NC(=O)[C@@H]1CC[C@@H]2CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N21)c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2205248	ChEMBL	8.96	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CO)CC[C@H]2C(=O)N[C@H](C(=O)NCCNC(=O)CCC#CC#CCCC(=O)NCCNC(=O)[C@@H](NC(=O)[C@@H]1CC[C@@H]2CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N21)c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL2204568	ChEMBL	8.3	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1Cn1cc(CCC(=O)NCCOCCOCCOCCNC(=O)[C@@H](NC(=O)[C@@H]3CC[C@@H]4CC[C@H](CO)[C@H](NC(=O)[C@H](CC)NC)C(=O)N43)c3ccccc3)nn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1.O=C(O)C(F)(F)F
E3 Binder	CHEMBL3094405	ChEMBL	9.0	—	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@@H]2Cc3cc(C#N)ccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094403	ChEMBL	8.85	—	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@@H]2Cc3cc(Cl)cc(Cl)c3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094404	ChEMBL	8.96	—	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@@H]2Cc3cc(Cl)ccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094408	ChEMBL	8.85	2DY	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@@H]2Cc3ccccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094407	ChEMBL	8.92	2DX	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@H]2CCCN2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL4460096	ChEMBL	8.55	—	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@H]2Cc3cc(Cl)ccc3N2C[C@H]1C(=O)N[C@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094409	ChEMBL	8.77	—	—	CC[C@H](NC)C(=O)N[C@H](C(=O)N1C[C@H]2Cc3ccccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL514738	ChEMBL	8.89	—	—	CC[C@H](NC)C(=O)N[C@H]1CCC[C@H]2CC[C@@H](C(=O)N(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL3696514	ChEMBL	7.19	—	—	CC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)c3ccccc3)cc21
E3 Binder	CHEMBL3699972	ChEMBL	7.72	—	—	CC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3696522	ChEMBL	6.89	—	—	CNC(=O)[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)c3ccccc3)cc21
E3 Binder	CHEMBL3958644	ChEMBL	7.55	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccc(C)cn2)n1
E3 Binder	CHEMBL3978628	ChEMBL	7.28	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccc(F)cn2)n1
E3 Binder	CHEMBL3937728	ChEMBL	7.23	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccc(OC)cn2)n1
E3 Binder	CHEMBL3975877	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)nc(C)c3c(=O)n(C)n(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3971543	ChEMBL	8.15	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)nc3cccc(C)n23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3955142	ChEMBL	8.0	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)nc3ccccn23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3929299	ChEMBL	8.3	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ncnc2C)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3927049	ChEMBL	8.52	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)noc2C)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3936420	ChEMBL	7.96	—	—	CNC(C)C(=O)Nc1cc(-c2c(Cl)cnc3ccccc23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3923542	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2c(OC)ccc3nccc(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3932969	ChEMBL	8.7	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3c2c(C)nn3C)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3967322	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3cncc(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3951871	ChEMBL	8.52	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3cnn(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3923211	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3nc(C)c(C)n23)cc(NC(=O)c2cc3c(cn2)COC3)n1
E3 Binder	CHEMBL3889562	ChEMBL	6.46	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3nc(C)c(C)n23)cc(NC(=O)c2cc3ccccc3[nH]2)n1
E3 Binder	CHEMBL3932853	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3nc(C)c(C)n23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3946388	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3nc(C)c(C)n23)cc(NC(=O)c2ccc(OC)cn2)n1
E3 Binder	CHEMBL3960445	ChEMBL	8.52	—	—	CNC(C)C(=O)Nc1cc(-c2cccc3nn(C)c(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3903484	ChEMBL	6.76	—	—	CNC(C)C(=O)Nc1cc(-c2cccnc2)c(-c2cncnc2)c(C#Cc2ccccc2)n1
E3 Binder	CHEMBL3938332	ChEMBL	8.1	—	—	CNC(C)C(=O)Nc1cc(-c2ccnc3cc(F)cc(F)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3931465	ChEMBL	6.6	—	—	CNC(C)C(=O)Nc1cc(-c2ccncc2)c(-c2cncnc2)c(C#Cc2ccccc2)n1
E3 Binder	CHEMBL3926020	ChEMBL	7.55	—	—	CNC(C)C(=O)Nc1cc(-c2ccncc2C#N)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3959673	ChEMBL	7.77	—	—	CNC(C)C(=O)Nc1cc(-c2ccncc2C)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3928237	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cnc3cccc(Cl)n23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3937672	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2cncc3ccn(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3935909	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2nc(C)nc3c(C)c(C)n(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3929287	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2nc(C)nc3c(C)nn(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3953439	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2nc(C)nc3c(C)nn(C)c23)cc(NC(=O)c2ncc(Cl)cc2F)n1
E3 Binder	CHEMBL3929227	ChEMBL	7.26	—	—	CNC(C)C(=O)Nc1cc(-c2nc(OC)nc3c(C)nn(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3969043	ChEMBL	8.52	—	—	CNC(C)C(=O)Nc1cc(-c2nccc3c(=O)n(C)n(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3975889	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2nccc3cccc(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3935487	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2cc(C)nc(C)c2)n1
E3 Binder	CHEMBL3963948	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2cc(F)c3ncccc3c2)n1
E3 Binder	CHEMBL3917949	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2cc(F)cc(F)c2)n1
E3 Binder	CHEMBL3926762	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccc(-n3cnc(C)c3)cc2)n1
E3 Binder	CHEMBL3909016	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccc3nc(C)ccc3c2)n1
E3 Binder	CHEMBL3898413	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2cnc3c(cnn3C)c2)n1
E3 Binder	CHEMBL3898998	ChEMBL	8.7	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(NC(=O)c2cc3c(cn2)COC3)n1
E3 Binder	CHEMBL3935993	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3944851	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(NC(=O)c2ncc(Cl)cc2C)n1
E3 Binder	CHEMBL3906797	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3cccc(Cl)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3946504	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3cccc(F)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3915777	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3nc(C)n(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3916269	ChEMBL	9.0	—	—	CNC(C)C(=O)Nc1cc(-c2ncnc3oc(C)c(C)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3943738	ChEMBL	7.02	—	—	CNC(C)C(=O)Nc1cc(-c2nn(C)c3ncnc(N)c23)cc(NC(=O)c2ccccn2)n1
E3 Binder	CHEMBL4552412	ChEMBL	7.82	—	—	CN[C@@H](C)C(=O)NC(Cc1cc(C)c(C(F)(F)F)cc1F)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(OS(=O)(=O)F)cccc21
E3 Binder	CHEMBL4276715	ChEMBL	7.76	—	—	CN[C@@H](C)C(=O)N[C@@H](CCN)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL5175233	ChEMBL	6.82	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5174454	ChEMBL	7.4	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5193194	ChEMBL	6.69	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5170823	ChEMBL	7.1	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5195146	ChEMBL	6.58	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)O)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5181541	ChEMBL	6.84	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1ccc(S(=O)(=O)F)c(OC)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4277819	ChEMBL	6.74	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1ccc(S(=O)(=O)F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4291896	ChEMBL	6.58	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cccc(S(=O)(=O)F)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4288478	ChEMBL	8.35	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1cc(C)c(C(F)(F)F)cc1F)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL4288043	ChEMBL	6.45	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(C(F)(F)F)c(Cl)c1)C(=O)N1CCC[C@@H]1c1cncc(Cc2ccccc2)n1
E3 Binder	CHEMBL4291176	ChEMBL	6.7	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(CP(=O)(O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4437401	ChEMBL	7.7	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(OS(=O)(=O)F)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL4283320	ChEMBL	6.84	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL4288451	ChEMBL	7.66	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc(S(=O)(=O)O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL4277802	ChEMBL	7.62	—	—	CN[C@@H](C)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL2431755	ChEMBL	6.57	—	—	CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(C#N)n(-c3ccccc3C#N)c3ccccc23)c2ccccc2OC12CCOCC2.Cl
E3 Binder	CHEMBL4280168	ChEMBL	7.32	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C
E3 Binder	CHEMBL4581366	ChEMBL	7.85	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(OS(=O)(=O)F)cccc21)C1CCCCC1
E3 Handle	CHEMBL2048500	PROTACpedia, PROTACDB3, ChEMBL	8.22	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)OC)C(c1ccccc1)c1ccccc1)C1CCCCC1
E3 Binder	CHEMBL3108931	ChEMBL	10.0	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108827	ChEMBL	10.0	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Handle	CHEMBL2063869	PROTACDB3, ChEMBL	7.98	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1snnc1-c1ccccc1)C1CCCCC1
E3 Binder	CHEMBL2204571	ChEMBL	7.9	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1Cn1nnnc1Sc1ccccc1)[C@H](C)OCC#CC#CCO[C@@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCC[C@H]1Cn1nnnc1Sc1ccccc1
E3 Handle	CHEMBL2431768	PROTACDB3, ChEMBL	9.4	IUN	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCCCC1
E3 Handle	CHEMBL4164385	PROTACDB3, ChEMBL	8.32	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2cccc(OC)c2)cs1)C1CCCCC1
E3 Binder	CHEMBL4172268	ChEMBL	6.66	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2cccc(OCCOCCOCCNC(=O)c3cccc(-c4cc(Nc5ccc(OC(F)(F)F)cc5)ncn4)c3)c2)cs1)C1CCCCC1
E3 Binder	CHEMBL1230673	ChEMBL	7.8	9JZ	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H](C)[C@H]1C(=O)Nc1ccccc1-c1ncccn1)C1CCCCC1
E3 Binder	CHEMBL479725	ChEMBL	6.89	419	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2CC[C@H](NC(=O)C(c3ccccc3)c3ccccc3)[C@H]21)C(C)(C)C
E3 Binder	CHEMBL511444	ChEMBL	7.48	G13	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2CC[C@H](NC(=O)c3cccc4ccccc34)[C@H]21)C(C)(C)C
E3 Binder	CHEMBL3339223	ChEMBL	8.3	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2ccc(CN(C(=O)[C@@H]3Cc4ccccc4CN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@@H](COC)c3ccccc3)cc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339221	ChEMBL	8.15	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2ccc(CN(C(=O)[C@@H]3Cc4ccccc4CN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](C)c3ccccc3F)cc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339224	ChEMBL	8.1	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2ccc(CN(C(=O)[C@@H]3Cc4ccccc4CN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](COC)c3ccccc3)cc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339220	ChEMBL	7.6	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2ccc(CN(C(=O)[C@@H]3Cc4ccccc4CN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H]3CCCc4ccccc43)cc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](Oc2ccccc2)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3094406	ChEMBL	8.66	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2CCCN2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL2365533	ChEMBL	8.68	1YH	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H]2CCCN2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3142652	ChEMBL	8.68	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H]2CCCN2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1.Cl.Cl
E3 Binder	CHEMBL3216147	ChEMBL	8.46	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H]2C[C@@H]3C[C@@H]3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1.Cl.Cl
E3 Binder	CHEMBL3216595	ChEMBL	7.55	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H]2C[C@H]3C[C@H]3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1.Cl.Cl
E3 Binder	CHEMBL3091493	ChEMBL	8.55	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H]2Cc3ccccc3N2C[C@H]1C(=O)N[C@@H]1CCOc2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3339216	ChEMBL	7.1	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(C#Cc3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339218	ChEMBL	7.96	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)Nc3nc4cc(C(=O)N[C@H]5C[C@@H](C(=O)N[C@@H]6CCCc7ccccc76)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C5)ccc4s3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339219	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)Nc3ncc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)o3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339217	ChEMBL	7.6	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(CCc3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339214	ChEMBL	8.0	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3339215	ChEMBL	7.12	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(OCc3ccc(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1C[C@H]2CC[C@@H]1N(CCc1ccccc1)C2)C1CCCCC1
E3 Binder	CHEMBL472832	ChEMBL	8.9	—	—	CN[C@@H](C)C(=O)N[C@H]1C/C=C\C[C@H]2[C@@H](Cc3ccccc3)C[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL481422	ChEMBL	9.1	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL1774160	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCCCCCCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774031	ChEMBL	8.55	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCCCCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774159	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCCCc4ccc(CCCCCCCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL2158599	ChEMBL	8.55	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774158	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCc4ccc(CCCCCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL1774163	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCOCCCCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774162	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCNC(=O)NCCCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774154	ChEMBL	9.3	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCc4ccc(CCCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL1774166	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCc4ccc(CCCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](Cc8c[nH]c9ccccc89)NC(C)=O)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL1774161	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCc4cn(CCCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774157	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCc4ccc(CCCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL1774164	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCOCCCCOCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774165	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCOCCOCCOCCn4cc([C@@H](NC(=O)[C@@H]5CC[C@@H]6CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N65)c5ccccc5)nn4)nn3)N2C1=O
E3 Binder	CHEMBL1774156	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCc4ccc(CCn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL1773083	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(Cc4ccc(Cn5cc([C@@H](NC(=O)[C@@H]6CC[C@@H]7CCCC[C@H](NC(=O)[C@H](C)NC)C(=O)N76)c6ccccc6)nn5)cc4)nn3)N2C1=O
E3 Binder	CHEMBL481213	ChEMBL	9.17	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL481421	ChEMBL	7.54	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2CC[C@@H](C(=O)N[C@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL475670	ChEMBL	9.43	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCC[C@H]2[C@@H](Cc3ccccc3)C[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL1095994	ChEMBL	6.79	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCCn2cc(nn2)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)CCCCn2cc(nn2)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O
E3 Binder	CHEMBL1095993	ChEMBL	7.96	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCCn2cc(nn2)[C@H](c2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)CCCCn2cc(nn2)[C@H](c2ccccc2)NC(=O)[C@@H]2CCCN2C1=O
E3 Binder	CHEMBL1095992	ChEMBL	7.08	—	—	CN[C@@H](C)C(=O)N[C@H]1CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O
E3 Binder	CHEMBL3236390	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)C(OCC#CC#CCOC(C(=O)N4CC[C@@H]5C[C@@H]6CCC[C@H](NC(=O)[C@H](C)NC)C(=O)N6[C@@H]5C4)c4ccccc4)c4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236382	ChEMBL	6.43	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)C(c4ccccc4)c4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236381	ChEMBL	7.18	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)Cc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236385	ChEMBL	6.66	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)OCc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3233043	ChEMBL	7.41	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236072	ChEMBL	7.46	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccccc4F)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236070	ChEMBL	7.3	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2SC(C)(C)C(C(=O)Nc3cc(C)nn3-c3ccccc3)N2C1=O
E3 Binder	CHEMBL1241424	ChEMBL	8.8	—	—	CN[C@@H](C)C(=O)N[C@H]1CC[C@@H](NC(=O)Cc2ccccc2)C[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL1241426	ChEMBL	8.59	—	—	CN[C@@H](C)C(=O)N[C@H]1CC[C@@H](NC(=O)Cc2ccccc2)C[C@H]2CC[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL1243385	ChEMBL	8.1	—	—	CN[C@@H](C)C(=O)N[C@H]1CC[C@@H](O)C[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL1241425	ChEMBL	7.91	—	—	CN[C@@H](C)C(=O)N[C@H]1CC[C@H](NC(=O)Cc2ccccc2)C[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL1242922	ChEMBL	8.18	—	—	CN[C@@H](C)C(=O)N[C@H]1CC[C@H](O)C[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158051	ChEMBL	8.72	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CC(C)C)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158054	ChEMBL	9.15	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CC(C)C)CC[C@H]2CC[C@@H](C(=O)N[C@@H](c3ccccc3)c3cn(CCCCCCCCCCNC(=O)c4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)nn3)N2C1=O
E3 Binder	CHEMBL2158600	ChEMBL	9.15	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158601	ChEMBL	9.4	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158602	ChEMBL	8.92	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCCCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158603	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCCCCCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158604	ChEMBL	8.72	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCCCCCCCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158606	ChEMBL	8.92	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCOCCCCC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158605	ChEMBL	8.54	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCc2ccc(CCCCC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348613	ChEMBL	7.86	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCc2ccc(CCC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348614	ChEMBL	8.3	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Cc2ccc(CC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL504559	ChEMBL	8.89	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Cc2ccccc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348617	ChEMBL	8.24	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)N2CCN(C(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)CC2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348615	ChEMBL	8.06	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)NCCCCCCCCNC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348616	ChEMBL	8.41	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)NCCCCNC(=O)N2CC[C@H]3CC[C@@H](C(=O)NC(c4ccccc4)c4ccccc4)N3C(=O)[C@@H](NC(=O)[C@H](C)NC)C2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348621	ChEMBL	8.33	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)NCc2cccc(CNC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)c2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348618	ChEMBL	8.27	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)N[C@H]2CC[C@H](NC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)CC2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348620	ChEMBL	8.31	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Nc2ccc(Cc3ccc(NC(=O)N4CC[C@H]5CC[C@@H](C(=O)NC(c6ccccc6)c6ccccc6)N5C(=O)[C@@H](NC(=O)[C@H](C)NC)C4)cc3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348623	ChEMBL	8.43	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Nc2ccc(NC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348619	ChEMBL	8.82	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Nc2ccc(Oc3ccc(NC(=O)N4CC[C@H]5CC[C@@H](C(=O)NC(c6ccccc6)c6ccccc6)N5C(=O)[C@@H](NC(=O)[C@H](C)NC)C4)cc3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2348622	ChEMBL	8.13	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)Nc2cccc(NC(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)c2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL2158607	ChEMBL	8.44	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(C(=O)N3CC[C@H]4CC[C@@H](C(=O)NC(c5ccccc5)c5ccccc5)N4C(=O)[C@@H](NC(=O)[C@H](C)NC)C3)cc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL456400	ChEMBL	8.96	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C(C)=O)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL515848	ChEMBL	7.89	—	—	CN[C@@H](C)C(=O)N[C@H]1Cc2ccccc2[C@H]2CCC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL515347	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H]1Cc2ccccc2[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL516172	ChEMBL	8.96	—	—	CN[C@@H](C)C(=O)N[C@H]1Cc2ccccc2[C@H]2CC[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL3896543	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccc(C)nc3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3964219	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccc(OC)nc3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3973040	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cccnc3C)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3895473	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cccnc3OC)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3930510	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cccnc3OC)nc3cc(C)ccn23)c(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL3974300	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cccnc3OC)nc3cc(Cl)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3956933	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cccnc3OC)nc3ccccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3958007	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccnc(C)c3)nc3cc(C)ccn23)c(C#Cc2ccccc2)n1
E3 Binder	CHEMBL3928571	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccnc(OC)c3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3969059	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccnc(OC)c3)nc3cc(C)ccn23)c(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL3967713	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cnc(C)nc3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3935923	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cnc(C)nc3)nc3cc(C)ccn23)c(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL3905467	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cncn3C)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3981054	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3cnn(C)c3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3979152	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)C(C)C)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3932160	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)C)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3895249	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)C)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3908827	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)C1CCC1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3896283	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)CC(C)(C)C)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3969310	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C(C)CC(C)C)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3940762	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3917778	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C1CCC(C)(C)CC1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3907712	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C1CCCC1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3955844	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C1CCCCC1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3978734	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(CC1CCCC1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3978606	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(c1cc(Cl)cc(Cl)c1)C(=O)N2c1cc(Cl)cc(Cl)c1
E3 Binder	CHEMBL3970314	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(c1cc(Cl)ccc1F)C(=O)N2c1ccccc1
E3 Binder	CHEMBL3970450	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(c1ccc(Cl)cc1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3946108	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(c1cccc(Cl)c1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3983433	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(c1ccccc1)C(=O)N2c1ccccc1
E3 Binder	CHEMBL3903476	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(C)(C)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3925194	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(C)(C)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3912475	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(C)(C1CCCC1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3917879	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(C)(CC(C)C)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3951508	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(C)(Cc1ccccc1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3975382	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC1(CCCC1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3906876	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC1(CCCCC1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3964665	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC1(Cc3ccccc3C1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3896796	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)O[C@@](C)(c1ccccc1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL4110909	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2c(C)nc(C)c3c(=O)n(C)n(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4109172	ChEMBL	7.23	—	—	CN[C@H](C)C(=O)Nc1cc(-c2c(OC)ccc3nc(C)ccc23)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4113639	ChEMBL	6.49	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ccc(OC)nc2)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4112689	ChEMBL	7.92	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3cnn(C)c23)c(OC)c(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4115218	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3nc(C)c(C)n23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4115311	ChEMBL	6.87	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3ncccc23)c(OC)c(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4112887	ChEMBL	6.6	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccnc2)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4112194	ChEMBL	6.55	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ccncc2)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4108099	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cnc3cccc(C)n23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4109659	ChEMBL	6.9	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cncc(F)c2)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4110049	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3c(C)nn(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4115053	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3c(C)nn(C)c23)cc(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL4108709	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3c(C)nn(C)c23)cc(C#Cc2ccc3c(cnn3C)c2)n1
E3 Binder	CHEMBL4113127	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3nn(C)c(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4107814	ChEMBL	8.7	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3nn(C)c(C)c23)cc(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL4107425	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3nn(C)c(C)c23)cc(C#Cc2ccc3c(cnn3C)c2)n1
E3 Binder	CHEMBL4110057	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3nn(C)c(C)c23)cc(C#Cc2cccs2)n1
E3 Binder	CHEMBL4110268	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2nc(C)nc3nn(C)c(C)c23)cc(C#Cc2cnc(-n3cnc(C)c3)nc2)n1
E3 Binder	CHEMBL4115526	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2cc(C)nc3c(F)cccc23)n1
E3 Binder	CHEMBL4114897	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4115565	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccc3c(cnn3C)c2)n1
E3 Binder	CHEMBL4115207	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccn3c(C)ncc3c2)n1
E3 Binder	CHEMBL4115656	ChEMBL	8.7	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3cnn(C)c23)cc(C#Cc2ccc(-n3cnc(C)c3)cc2)n1
E3 Binder	CHEMBL4106485	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3cnn(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4108098	ChEMBL	9.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3cnn(C)c23)cc(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL4107160	ChEMBL	8.7	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3cnn(C)c23)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4112542	ChEMBL	8.7	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ncnc3oc(C)c(C)c23)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4109627	ChEMBL	6.3	—	—	CN[C@H](C)C(=O)Nc1ccc2c(n1)OC(C)(CCC(C)N)C(=O)N2c1ccccc1
E3 Binder	CHEMBL3700020	ChEMBL	6.55	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(-c3nc(C)no3)c(Cl)cc21
E3 Binder	CHEMBL3699951	ChEMBL	7.77	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(=O)n(Cc3ccccc3)cc21
E3 Binder	CHEMBL3700013	ChEMBL	6.23	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(C)c(C#N)cc21
E3 Binder	CHEMBL3699947	ChEMBL	7.17	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)c3ccc(OC)cc3)cc21
E3 Binder	CHEMBL3699945	ChEMBL	7.35	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(F)c(S(=O)(=O)c3ccccc3)cc21
E3 Binder	CHEMBL3699997	ChEMBL	6.15	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(C#N)cc21
E3 Binder	CHEMBL3699975	ChEMBL	7.85	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3699949	ChEMBL	6.85	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(S(=O)(=O)CC(C)C)cc21
E3 Binder	CHEMBL3699954	ChEMBL	6.09	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(S(=O)(=O)Cc3ccccc3)cc21
E3 Binder	CHEMBL3700028	ChEMBL	7.85	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(-c3cc4ccccc4o3)cc21
E3 Binder	CHEMBL3700026	ChEMBL	7.35	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(-c3ccc(C)s3)cc21
E3 Binder	CHEMBL3700024	ChEMBL	6.75	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(-c3ccoc3)cc21
E3 Binder	CHEMBL3700005	ChEMBL	7.07	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(-c3ccsc3)cc21
E3 Binder	CHEMBL3699984	ChEMBL	6.06	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C#N)cc21
E3 Binder	CHEMBL3699977	ChEMBL	7.11	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C(=O)c3ccccc3)cc21
E3 Binder	CHEMBL3700053	ChEMBL	6.6	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C(C)(F)F)cc21
E3 Binder	CHEMBL3699968	ChEMBL	7.62	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C(C)c3ccccc3)cc21
E3 Binder	CHEMBL3700025	ChEMBL	7.77	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C(F)(F)c3ccccc3)cc21
E3 Binder	CHEMBL3700011	ChEMBL	7.35	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C(OC)c3ccccc3)cc21
E3 Binder	CHEMBL3699971	ChEMBL	7.1	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3=CCCC3)cc21
E3 Binder	CHEMBL3699987	ChEMBL	7.64	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3=CCCCC3)cc21
E3 Binder	CHEMBL3699998	ChEMBL	6.62	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3CCCCC3)cc21
E3 Binder	CHEMBL3699962	ChEMBL	7.6	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(CC3CCCCC3)cc21
E3 Binder	CHEMBL3699958	ChEMBL	7.8	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(CCC(C)C)cc21
E3 Binder	CHEMBL3699979	ChEMBL	7.64	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccc(OC)cc3)cc21
E3 Binder	CHEMBL3699967	ChEMBL	7.92	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(Cl)c3)cc21
E3 Binder	CHEMBL3699978	ChEMBL	7.77	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(F)c3)cc21
E3 Binder	CHEMBL3699970	ChEMBL	7.8	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(OC)c3)cc21
E3 Binder	CHEMBL3600717	ChEMBL	8.0	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3699961	ChEMBL	7.46	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3Cl)cc21
E3 Binder	CHEMBL3699960	ChEMBL	8.05	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3F)cc21
E3 Binder	CHEMBL3600735	ChEMBL	6.5	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cl)cc21
E3 Binder	CHEMBL3699999	ChEMBL	7.02	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3c(C)cccc3C)cc21
E3 Binder	CHEMBL3700009	ChEMBL	7.36	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3c(C)cccc3Cl)cc21
E3 Binder	CHEMBL3700007	ChEMBL	6.92	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3c(F)cccc3F)cc21
E3 Binder	CHEMBL3699957	ChEMBL	7.0	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3ccccc3)cc21
E3 Binder	CHEMBL3699965	ChEMBL	6.96	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3ccccc3C)cc21
E3 Binder	CHEMBL3699991	ChEMBL	7.46	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Oc3ccccc3Cl)cc21
E3 Binder	CHEMBL3700016	ChEMBL	7.85	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3700015	ChEMBL	6.72	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(c2ccccc2)c2ccc(C#N)cc21
E3 Binder	CHEMBL3700023	ChEMBL	7.92	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(c2ccccn2)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3700040	ChEMBL	7.89	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(c2cccnc2)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3699959	ChEMBL	7.8	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC2(CN(C(C)=O)C2)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3699955	ChEMBL	6.27	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC2(CN(C(C)=O)C2)c2ccc(Cl)cc21
E3 Binder	CHEMBL3700000	ChEMBL	6.77	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC2(Cc3ccccc3C2)c2ccc(Cl)cc21
E3 Binder	CHEMBL3700046	ChEMBL	6.5	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@@](C)(COC)c2ccc(Br)cc21
E3 Binder	CHEMBL3700050	ChEMBL	7.96	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@@](C)(c2cc(C)no2)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3700018	ChEMBL	6.72	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@@](C)(c2ccccc2)c2ccc(C#N)cc21
E3 Binder	CHEMBL3700049	ChEMBL	6.72	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@](C)(c2cc(C)no2)c2ccc(Cc3ccccc3)cc21
E3 Binder	CHEMBL3700019	ChEMBL	6.66	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@](C)(c2ccccc2)c2ccc(C#N)cc21
E3 Binder	CHEMBL4167141	ChEMBL	9.89	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3[nH]c(=O)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Handle	CHEMBL4169478	PROTACDB3, ChEMBL	9.74	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3c2cc(Cc2ccc(F)cc2)c(=O)n3C)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL4177336	ChEMBL	9.15	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cc(=O)n(Cc4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL3696513	ChEMBL	6.41	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cc(F)c(S(=O)(=O)c4ccccc4)cc32)CCN1
E3 Binder	CHEMBL3696509	ChEMBL	7.17	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(Cc4ccccc4)cc32)[C@@H](CO)CN1
E3 Binder	CHEMBL3699989	ChEMBL	6.55	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(Cl)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3696507	ChEMBL	6.09	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(Cl)cc32)[C@@H](CO)CN1
E3 Binder	CHEMBL3700017	ChEMBL	6.48	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(Cl)cc32)[C@@H](Cn2cccn2)CN1
E3 Binder	CHEMBL3696510	ChEMBL	6.35	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ccc(S(=O)(=O)c4ccccc4)cc32)CCN1
E3 Binder	CHEMBL3700055	ChEMBL	7.51	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(C(C)(F)F)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700080	ChEMBL	7.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(C(F)(F)C4CC4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700085	ChEMBL	7.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2CCCC2)CN1
E3 Binder	CHEMBL3699980	ChEMBL	7.92	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc32)[C@@H](C(=O)N(C)C)CN1
E3 Binder	CHEMBL3699981	ChEMBL	7.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc32)[C@@H](C(=O)N2CCC2)CN1
E3 Binder	CHEMBL3700001	ChEMBL	7.54	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc32)[C@@H](C(F)F)CN1
E3 Binder	CHEMBL3639988	ChEMBL	7.68	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc32)[C@@H](CF)CN1
E3 Binder	CHEMBL3700051	ChEMBL	7.75	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc32)[C@@H](Cn2cc(F)cn2)CN1
E3 Binder	CHEMBL4173974	ChEMBL	9.66	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nc(CO)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCOC[C@H]2C)CN1
E3 Binder	CHEMBL4166057	ChEMBL	10.0	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nc(CO)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL3700058	ChEMBL	7.5	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(=O)c4ccccc4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700059	ChEMBL	7.4	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(C)(F)F)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700090	ChEMBL	7.62	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(C)(F)F)cc32)[C@@H](CN2CCN(C)C(=O)C2)CN1
E3 Binder	CHEMBL3700087	ChEMBL	6.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(C)(F)F)cc32)[C@@H](CN2CCc3cccnc32)CN1
E3 Binder	CHEMBL3700089	ChEMBL	7.68	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(F)(F)C4CCC4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700091	ChEMBL	8.02	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(F)(F)CC4CC4)cc32)[C@@H](CN2CCOCC2)CN1
E3 Binder	CHEMBL4081831	ChEMBL	7.7	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(C(F)(F)c4ccccc4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL4092217	ChEMBL	8.64	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL3700093	ChEMBL	8.6	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCOCC2)CN1
E3 Binder	CHEMBL3700098	ChEMBL	8.62	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCOC[C@@H]2C)CN1
E3 Handle	CHEMBL4064619	PROTACDB3, ChEMBL	9.49	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCOC[C@H]2C)CN1
E3 Binder	CHEMBL4172596	ChEMBL	8.19	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2C[C@@H](C)OCC2=O)CN1
E3 Binder	CHEMBL4159855	ChEMBL	8.38	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2C[C@@H](C)OC[C@H]2C)CN1
E3 Binder	CHEMBL4175992	ChEMBL	8.89	FUE	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2Cc3ccccc3C2=O)CN1
E3 Binder	CHEMBL4168197	ChEMBL	9.21	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@@H]2C)CN1
E3 Binder	CHEMBL4166607	ChEMBL	9.72	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL3700068	ChEMBL	8.62	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL4159232	ChEMBL	9.23	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4O)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL3700047	ChEMBL	7.96	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccccc4)cc32)[C@@H](C(=O)N(C)C)CN1
E3 Binder	CHEMBL3700052	ChEMBL	8.12	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccccc4)cc32)[C@@H](CN2CCCC2=O)CN1
E3 Binder	CHEMBL4170539	ChEMBL	8.46	FUK	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc([C@@H](O)c4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL4162607	ChEMBL	8.64	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc([C@H](O)c4ccc(F)cc4)cc32)[C@@H](CN2[C@H](C)COC[C@H]2C)CN1
E3 Binder	CHEMBL4168144	ChEMBL	8.6	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4)cc32)[C@@H](CN2Cc3ccccc3C2=O)CN1
E3 Binder	CHEMBL4171490	ChEMBL	9.77	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3c(F)cccc3C2=O)CN1
E3 Binder	CHEMBL4167717	ChEMBL	9.0	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3cc(C#N)ccc3C2=O)CN1
E3 Binder	CHEMBL4164271	ChEMBL	9.7	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3cc(F)ccc3C2=O)CN1
E3 Binder	CHEMBL4159806	ChEMBL	8.8	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3ccc(C#N)cc3C2=O)CN1
E3 Binder	CHEMBL4174922	ChEMBL	9.13	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3ccc(F)cc3C2=O)CN1
E3 Binder	CHEMBL4160872	ChEMBL	9.47	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3nnc(Cc4ccc(F)cc4F)cc32)[C@@H](CN2Cc3ccccc3C2=O)CN1
E3 Binder	CHEMBL3700027	ChEMBL	6.89	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3700022	ChEMBL	6.7	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](Cn2cccn2)CN1
E3 Binder	CHEMBL3699990	ChEMBL	6.82	—	—	C[C@@H]1CN(CC(=O)N2CC3(Cc4ccccc4C3)c3ccc(C#N)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3700021	ChEMBL	6.82	—	—	C[C@@H]1CN(CC(=O)N2CC3(Cc4ccccc4C3)c3ccc(Cl)cc32)[C@@H](Cn2cccn2)CN1
E3 Binder	CHEMBL3700030	ChEMBL	6.96	—	—	C[C@@H]1CN(CC(=O)N2C[C@@](C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3700032	ChEMBL	6.77	—	—	C[C@@H]1CN(CC(=O)N2C[C@@](C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](Cn2cccn2)CN1
E3 Binder	CHEMBL3700033	ChEMBL	6.58	—	—	C[C@@H]1CN(CC(=O)N2C[C@](C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](Cn2cccn2)CN1
E3 Binder	CHEMBL3700038	ChEMBL	6.96	—	—	Cc1cnn(C[C@H]2CN[C@H](C)CN2CC(=O)N2CC3(Cc4ccccc4C3)c3ccc(C#N)cc32)c1
E3 Binder	CHEMBL3108926	ChEMBL	6.54	—	—	C#CCO[C@@H]1CCc2ccccc2[C@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C
E3 Binder	CHEMBL3696511	ChEMBL	6.24	—	—	CC(=O)NC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(Cl)cc21
E3 Handle	—	PROTACDB3	6.0*	BES	—	CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O
E3 Binder	CHEMBL3699995	ChEMBL	6.17	—	—	CC1(C)CN(C(=O)CN2CCN[C@H](CF)C2)c2cc(Cc3ccccc3)ncc21
E3 Binder	CHEMBL3700067	ChEMBL	7.64	—	—	CCC(F)(F)c1cc2c(cn1)C(C)(C)CN2C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCCC1=O
E3 Binder	CHEMBL3700057	ChEMBL	7.96	—	—	CCC(F)(F)c1cnc2c(c1)N(C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCOC[C@H]1C)CC2(C)C
E3 Binder	CHEMBL3700002	ChEMBL	6.28	—	—	CCC1(C)CN(C(=O)CN2C[C@@H](C)NC[C@@H]2COC)c2cc(Cl)ccc21
E3 Binder	CHEMBL457292	ChEMBL	6.28	—	—	CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C)C(=O)OC
E3 Binder	CHEMBL458592	ChEMBL	6.08	—	—	CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC
E3 Binder	CHEMBL3931762	ChEMBL	6.3	—	—	CCCN1Cc2nc(NC(=O)[C@H](C)NC)ccc2N(c2ccccc2)C1=O
E3 Binder	CHEMBL3940501	ChEMBL	8.22	—	—	CCNC(CC)C(=O)Nc1cc(-c2ncnc3c(C)nn(C)c23)cc(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3700105	ChEMBL	7.85	—	—	CC[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(C(F)(F)CC)cc21
E3 Binder	CHEMBL4079500	ChEMBL	8.22	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCCCCCCCCCNC(=O)CN(Cc1ccccn1)Cc1ccccn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL4070316	ChEMBL	8.87	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CCNC(=O)CN(Cc1ccccn1)Cc1ccccn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL4091245	ChEMBL	8.82	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)CN(Cc1ccccn1)Cc1ccccn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL4097534	ChEMBL	8.78	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)COCCOCCNC(=O)CN(Cc1ccccn1)Cc1ccccn1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL4084120	ChEMBL	8.85	—	—	CC[C@H](NC)C(=O)N[C@@H]1C(=O)N2[C@@H](CC[C@@H]1CNC(=O)c1ccccc1)CC[C@H]2C(=O)NC(c1ccccc1)c1ccccc1
E3 Binder	CHEMBL3699976	ChEMBL	6.17	—	—	CC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cn3cccn3)cc21
E3 Handle	—	PROTACpedia	6.0*	—	—	CNC(=O)[C@H](CC(C)C)NC(=O)CCCc1ccccc1
E3 Handle	—	PROTACpedia	6.0*	—	—	CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1
E3 Binder	CHEMBL3983891	ChEMBL	7.51	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2cc3c(cn2)COC3)n1
E3 Binder	CHEMBL3913142	ChEMBL	6.88	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2cc3ccccc3cn2)n1
E3 Binder	CHEMBL3945899	ChEMBL	6.29	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2cc3ccccc3o2)n1
E3 Binder	CHEMBL3959727	ChEMBL	7.44	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccc(C#N)cn2)n1
E3 Binder	CHEMBL3957993	ChEMBL	6.77	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccc3ccccc3n2)n1
E3 Binder	CHEMBL3986011	ChEMBL	6.22	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2cccc(C)n2)n1
E3 Binder	CHEMBL3975253	ChEMBL	6.26	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccccn2)n1
E3 Binder	CHEMBL3970113	ChEMBL	6.15	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccn(C)n2)n1
E3 Binder	CHEMBL3983236	ChEMBL	6.37	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ccncn2)n1
E3 Binder	CHEMBL3941154	ChEMBL	6.98	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2cnc(C)cn2)n1
E3 Binder	CHEMBL3932220	ChEMBL	7.28	—	—	CNC(C)C(=O)Nc1cc(-c2c(C)ccc3ncccc23)cc(NC(=O)c2ncc3ccccc3n2)n1
E3 Binder	CHEMBL3946563	ChEMBL	7.75	—	—	CNC(C)C(=O)Nc1cc(-c2c(Cl)c(C)nc3cc(Cl)cc(Cl)c23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3952463	ChEMBL	6.65	—	—	CNC(C)C(=O)Nc1cc(-c2c(OC)ccc3ccccc23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL3901338	ChEMBL	7.3	—	—	CNC(C)C(=O)Nc1cc(-c2c(OC)ccc3nccnc23)cc(NC(=O)c2ccc(Cl)cn2)n1
E3 Binder	CHEMBL5169527	ChEMBL	6.13	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
E3 Binder	CHEMBL5203019	ChEMBL	6.82	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCCC[C@H]1C(=O)N[C@@H]1CCc2ccccc21
E3 Binder	CHEMBL5191180	ChEMBL	6.94	—	—	CN[C@@H](C)C(=O)N[C@@H](CNC(=O)c1cc(S(=O)(=O)F)ccc1OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCc2c(F)cccc21
E3 Binder	CHEMBL3108922	ChEMBL	9.52	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC=C[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1C=CCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Binder	CHEMBL3108822	ChEMBL	8.3	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NC1(C(=O)NCC#CC#CCNC(=O)C2(NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)Cc3ccccc3C2)Cc2ccccc2C1)C1CCCCC1
E3 Binder	CHEMBL3108821	ChEMBL	9.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]1CCN(CC#CC#CCN2CC[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)c3ccccc32)c2ccccc21)C1CCCCC1
E3 Binder	CHEMBL3108928	ChEMBL	8.4	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]1c2ccccc2CC[C@@H]1OCC#CC#CCO[C@H]1CCc2ccccc2[C@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108930	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]1c2ccccc2CC[C@H]1OCC#CC#CCO[C@@H]1CCc2ccccc2[C@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108929	ChEMBL	9.22	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2CC[C@@H]1OCC#CC#CCO[C@H]1CCc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108927	ChEMBL	9.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2CC[C@H]1OCC#CC#CCO[C@@H]1CCc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108818	ChEMBL	9.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@@H]1OCC#CC#CCO[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Binder	CHEMBL3108825	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1NC(=O)CCCCCCCCC(=O)N[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Binder	CHEMBL3108824	ChEMBL	7.82	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1NC(=O)c1ccc(-c2ccc(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C3CCCCC3)cc2)cc1)C1CCCCC1
E3 Binder	CHEMBL3108823	ChEMBL	6.91	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1NC(=O)c1ccc(C(=O)N[C@@H]2Cc3ccccc3[C@@H]2NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)cc1)C1CCCCC1
E3 Binder	CHEMBL3108826	ChEMBL	8.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C(C)C
E3 Binder	CHEMBL3108819	ChEMBL	10.0	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCCCCCCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Binder	CHEMBL3108820	ChEMBL	9.22	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCCOCCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Binder	CHEMBL1950720	ChEMBL	7.57	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2CCN(CCc3ccccc3)C[C@H]21)C1CCCCC1
E3 Binder	CHEMBL3108921	ChEMBL	9.22	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CSC2(CC2)[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)CSC12CC2)C1CCCCC1
E3 Binder	CHEMBL3108919	ChEMBL	9.3	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CSC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CSCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C
E3 Binder	CHEMBL3108920	ChEMBL	9.7	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1CSC[C@H]1C(=O)N[C@H]1c2ccccc2C[C@H]1OCC#CC#CCO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@@H]1CSCN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1)C1CCCCC1
E3 Handle	—	PROTACDB3	6.0*	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C1CCCCC1
E3 Handle	—	PROTACDB3	6.0*	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](N)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C
E3 Binder	CHEMBL3414728	ChEMBL	8.3	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)OCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C1)C(C)(C)C
E3 Binder	CHEMBL3414726	ChEMBL	7.23	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)OCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C1)C(C)C
E3 Binder	CHEMBL3414727	ChEMBL	8.15	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)OCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)C1)C1CCCCC1
E3 Binder	CHEMBL3414729	ChEMBL	8.52	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](C(=O)O)Cc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@H](C(=O)O)Cc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C1)C(C)C
E3 Binder	CHEMBL3414725	ChEMBL	7.47	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1cccc3ccccc13)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3cccc4ccccc34)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)OCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C1)C(C)C
E3 Binder	CHEMBL3414723	ChEMBL	7.16	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)NC(=O)CCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)NC(=O)CCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C1)C(C)C
E3 Binder	CHEMBL3414724	ChEMBL	7.35	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H]2C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)OCc1cn(nn1)[C@H]1C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](C(=O)O)Cc3ccc(cc3)OCc3cn2nn3)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)C)C1)C(C)C
E3 Binder	CHEMBL3410876	ChEMBL	8.35	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410872	ChEMBL	8.32	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)C(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410809	ChEMBL	7.77	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)C(F)(F)C(F)(F)C(F)(F)C(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410871	ChEMBL	8.4	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)C3(C(=O)N[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)CCC3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410808	ChEMBL	8.47	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)CCCC(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410874	ChEMBL	8.25	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410875	ChEMBL	8.54	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410807	ChEMBL	8.38	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(CCN[C@H]4C[C@@H](C(=O)N[C@@H]5CCCc6ccccc65)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C4)cc3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410873	ChEMBL	8.33	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NCC(=O)N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410877	ChEMBL	8.47	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(N[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410878	ChEMBL	8.44	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(O[C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3410879	ChEMBL	8.31	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Handle	—	PROTACDB3	6.0*	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C
E3 Binder	CHEMBL3108817	ChEMBL	10.0	—	—	CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H]2c3ccccc3C[C@H]2OCC#CC#CCO[C@@H]2Cc3ccccc3[C@@H]2NC(=O)[C@@H]2C[C@@H]3C[C@@H]3N2C(=O)[C@@H](NC(=O)[C@H](C)NC)C2CCCCC2)C[C@@H]2C[C@@H]21)C1CCCCC1
E3 Binder	CHEMBL3236387	ChEMBL	6.66	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)Nc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236386	ChEMBL	7.28	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(C(=O)Oc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236368	ChEMBL	6.75	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CC(C)c4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236377	ChEMBL	6.29	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CC4CCCCC4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236376	ChEMBL	6.5	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCC4CCCCC4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236369	ChEMBL	7.2	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4c[nH]c5ccccc45)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236071	ChEMBL	7.62	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(Br)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3233046	ChEMBL	7.05	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(C(F)(F)F)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236080	ChEMBL	7.14	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(C)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236366	ChEMBL	7.38	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(Cl)c(Cl)c4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236081	ChEMBL	7.43	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(Cl)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236073	ChEMBL	7.68	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(F)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236077	ChEMBL	7.26	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(O)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236076	ChEMBL	6.8	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc(OC)cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236367	ChEMBL	7.36	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccc([N+](=O)[O-])cc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236079	ChEMBL	7.0	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4cccc(C)c4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236075	ChEMBL	7.16	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4cccc(OC)c4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236078	ChEMBL	7.44	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccccc4C)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236074	ChEMBL	7.36	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccccc4OC)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236371	ChEMBL	6.4	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4ccccn4)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236370	ChEMBL	6.54	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(CCc4scnc4C)C[C@H]3N2C1=O
E3 Binder	CHEMBL3236374	ChEMBL	6.35	—	—	CN[C@@H](C)C(=O)N[C@H]1CCC[C@H]2C[C@H]3CCN(Cc4ccccc4)C[C@H]3N2C1=O
E3 Binder	CHEMBL461456	ChEMBL	8.48	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(C)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL506213	ChEMBL	8.43	—	—	CN[C@@H](C)C(=O)N[C@H]1CN(Cc2ccccc2)CC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL459541	ChEMBL	8.92	—	—	CN[C@@H](C)C(=O)N[C@H]1CNCC[C@H]2CC[C@@H](C(=O)NC(c3ccccc3)c3ccccc3)N2C1=O
E3 Binder	CHEMBL458791	ChEMBL	6.82	—	—	CN[C@@H](C)C(=O)N[C@H]1Cc2ccccc2[C@H]2CC[C@@H](C(=O)N[C@H]3CCCc4ccccc43)N2C1=O
E3 Binder	CHEMBL3929505	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccc(OC)nc3)nc3cc(C)ccn23)c(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL3911035	ChEMBL	9.0	—	—	CN[C@@H](C)C(=O)Nc1ccc(-c2c(-c3ccnc(C)c3)nc3cc(C)ccn23)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL3970943	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(C1CCN(C(C)=O)CC1)C(=O)N2c1cccc(Cl)c1
E3 Binder	CHEMBL3904793	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(CCc1ccccc1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3892200	ChEMBL	7.0	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(Cc1ccccc1)C(=O)N2c1ccccc1
E3 Binder	CHEMBL3900529	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CN(Cc1cscn1)C(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3954799	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CNC(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL3969247	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)CNC(=O)N2c1ccccc1
E3 Binder	CHEMBL3897994	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OC(Cc1ccccc1)C(=O)N2
E3 Binder	CHEMBL3902848	ChEMBL	6.3	—	—	CN[C@@H](C)C(=O)Nc1ccc2c(n1)OCC(=O)N2c1ccc(Cl)cc1
E3 Binder	CHEMBL4106789	ChEMBL	6.45	—	—	CN[C@H](C)C(=O)Nc1cc(-c2ccc(C(F)(F)F)nc2)cc(C#Cc2ccccc2)n1
E3 Binder	CHEMBL4107271	ChEMBL	7.92	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3cnn(C)c23)c(Cl)c(C#Cc2ccc3c(C)nccc3c2)n1
E3 Binder	CHEMBL4111060	ChEMBL	8.0	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3cnn(C)c23)c(Cl)c(C#Cc2ccc3c(ccc(=O)n3C)c2)n1
E3 Binder	CHEMBL4114456	ChEMBL	7.96	—	—	CN[C@H](C)C(=O)Nc1cc(-c2cccc3cnn(C)c23)cc(C#Cc2ccc3c(c2)CC(=O)N3C)n1
E3 Handle	—	PROTACDB3	6.0*	—	—	COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C
E3 Handle	CHEMBL457092	PROTACpedia, ChEMBL	6.16	—	—	COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1
E3 Binder	CHEMBL3700008	ChEMBL	6.32	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C(=O)OC)c2ccc(Br)cc21
E3 Binder	CHEMBL3700004	ChEMBL	6.14	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(CN3CCCC3=O)cc21
E3 Binder	CHEMBL3700107	ChEMBL	6.17	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(Cc3ccccc3)nc21
E3 Binder	CHEMBL3600734	ChEMBL	6.19	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(Cl)cc21
E3 Binder	CHEMBL3700003	ChEMBL	6.26	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(-c3cnn(C)c3)cc21
E3 Binder	CHEMBL3699973	ChEMBL	6.57	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(C3CCCC3)cc21
E3 Binder	CHEMBL3699956	ChEMBL	6.51	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(CC(C)C)cc21
E3 Binder	CHEMBL3699963	ChEMBL	7.48	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(C#N)c3)cc21
E3 Binder	CHEMBL3699983	ChEMBL	6.19	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(N3CCCC3=O)cc21
E3 Binder	CHEMBL3700054	ChEMBL	6.2	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2nnc(Cl)cc21
E3 Binder	CHEMBL3700006	ChEMBL	6.46	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(COC)c2ccc(Br)cc21
E3 Binder	CHEMBL3699988	ChEMBL	6.26	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(Cc2ccccc2)c2ccc(Cl)cc21
E3 Binder	CHEMBL3700045	ChEMBL	6.05	—	—	COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@](C)(COC)c2ccc(Br)cc21
E3 Binder	CHEMBL3700029	ChEMBL	7.72	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc32)[C@@H](C(=O)N(C)C)CN1
E3 Binder	CHEMBL3700042	ChEMBL	7.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3700060	ChEMBL	7.85	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc32)[C@@H](CN2CCOC2=O)CN1
E3 Binder	CHEMBL3700108	ChEMBL	7.39	—	—	C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc32)CCN1
E3 Binder	CHEMBL3696503	ChEMBL	6.02	—	—	C[C@@H]1CN(CC(=O)N2CCc3cnc(Cc4ccccc4)cc32)CCN1
E3 Binder	CHEMBL3700031	ChEMBL	6.8	—	—	C[C@@H]1CN(CC(=O)N2C[C@](C)(c3ccccc3)c3ccc(C#N)cc32)[C@@H](C(=O)N2CCOCC2)CN1
E3 Binder	CHEMBL3930490	ChEMBL	6.38	—	—	Cc1ccc(C(=O)Nc2cccc(NC(=O)C(C)N)n2)nc1
E3 Binder	CHEMBL3969548	ChEMBL	7.35	—	—	Cc1cccc2ccn(-c3cc(NC(=O)c4ccc(Cl)cn4)nc(NC(=O)C(C)N)c3)c12