MKRN4

Details:

UniProt Entry: Q13434
Gene: MKRN4P
Class: RING
Family: RING1
Protein length: 485
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q13434
MAEAAAPGTT VTTSGAGAAA AEAAETAEAV SPTPIPTVTA PSPRAGGGVG GSDGSDGSGG
RGDSGAYDGS GACGGSDACD GSGDSSGDSW TKQVTCRYFK YGICKEGDNC RYSHDLSDRL
CGVVCKYFQR GCCVYGDRCR CEHSKPLKQE EATATELTTK SSLAASSSLS SIVGPLVEMN
TNEAESRNSN FATVVAGSED WANAIEFVPG QPYCGRTVPS CTEAPLQGSV TKEESEEEQT
AVETKKQLCP YAAVGQCRYG ENCVYLHGDL CDMCGLQVLH PMDAAQRSQH IQACIEAHEK
DMEFSFAVQR SKDKVCGICM EVVYEKANPN EHRFGILSNC NHTFCLKCIR KWRSAKEFES
RIVKSCPQCR ITSNFVIPSE YWVEEKEEKQ KLIQKYKEAM SNKACKYFDE GRGSCPFGEN
CFYKHMYPDG RREEPQRQQV GTSSRNPGQQ RNHFWEFFEE GANSNPFDDE EEAVTFELGE
MLLML

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
90	116	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
90	117	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
91	115	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
94	484	Family	MKRN-like	IPR045072	PTHR11224
95	115	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
120	145	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
124	146	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
243	268	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
243	270	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
243	269	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
248	268	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
295	404	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
316	369	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
316	370	Domain	Zinc finger, RING-type	IPR001841	PS50089
316	369	Domain	Zinc finger, RING-type	IPR001841	SM00184
340	349	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
399	428	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
401	427	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
427	485	Domain	E3 ubiquitin-protein ligase makorin 1, C-terminal	IPR031644	PF15815

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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