PPIL2

Details:

UniProt Entry: Q13356
Gene: PPIL2
Class: RING
Family: RING1
Protein length: 520
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 1zkc, 7abi, 7dvq

Protein Sequence ▾

>Q13356
MGKRQHQKDK MYITCAEYTH FYGGKKPDLP QTNFRRLPFD HCSLSLQPFV YPVCTPDGIV
FDLLNIVPWL KKYGTNPSNG EKLDGRSLIK LNFSKNSEGK YHCPVLFTVF TNNTHIVAVR
TTGNVYAYEA VEQLNIKAKN FRDLLTDEPF SRQDIITLQD PTNLDKFNVS NFYHVKNNMK
IIDPDEEKAK QDPSYYLKNT NAETRETLQE LYKEFKGDEI LAATMKAPEK KKVDKLNAAH
YSTGKVSASF TSTAMVPETT HEAAAIDEDV LRYQFVKKKG YVRLHTNKGD LNLELHCDLT
PKTCENFIRL CKKHYYDGTI FHRSIRNFVI QGGDPTGTGT GGESYWGKPF KDEFRPNLSH
TGRGILSMAN SGPNSNRSQF FITFRSCAYL DKKHTIFGRV VGGFDVLTAM ENVESDPKTD
RPKEEIRIDA TTVFVDPYEE ADAQIAQERK TQLKVAPETK VKSSQPQAGS QGPQTFRQGV
GKYINPAATK RAAEEEPSTS ATVPMSKKKP SRGFGDFSSW

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
35	108	Domain	U-box domain	IPR003613	PS51698
38	110	Domain	Peptidyl-prolyl cis-trans isomerase like 2, U-box domain	IPR026951	cd16663
41	96	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
42	101	Domain	U-box domain	IPR003613	SM00504
258	439	Homologous_superfamily	Cyclophilin-like domain superfamily	IPR029000	G3DSA:2.40.100.10
277	443	Family	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like	IPR044666	PTHR45625
281	432	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PF00160
281	448	Homologous_superfamily	Cyclophilin-like domain superfamily	IPR029000	SSF50891
285	433	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PS50072
295	310	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PR00153
316	333	Conserved_site	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	IPR020892	PS00170
321	333	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PR00153
364	379	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PR00153
379	391	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PR00153
392	407	Domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	IPR002130	PR00153

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0006397	mRNA processing	Biological Process	IEA	GO_REF:0000043
GO:0006457	protein folding	Biological Process	IEA	GO_REF:0000002
GO:0008380	RNA splicing	Biological Process	IEA	GO_REF:0000043
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:11435423
GO:0072659	protein localization to plasma membrane	Biological Process	IMP	PMID:15946952
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005681	spliceosomal complex	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:15946952
GO:0005796	Golgi lumen	Cellular Component	TAS	Reactome:R-HSA-204500
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:15946952
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016853	isomerase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:15946952
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:11435423

Enzyme–Substrate Interactions ▾

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