SKP2

Details:

UniProt Entry: Q13309
Gene: SKP2
Class: Other E3 Components
Family: Receptor
Protein length: 424
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q13309
MHRKHLQEIP DLSSNVATSF TWGWDSSKTS ELLSGMGVSA LEKEEPDSEN IPQELLSNLG
HPESPPRKRL KSKGSDKDFV IVRRPKLNRE NFPGVSWDSL PDELLLGIFS CLCLPELLKV
SGVCKRWYRL ASDESLWQTL DLTGKNLHPD VTGRLLSQGV IAFRCPRSFM DQPLAEHFSP
FRVQHMDLSN SVIEVSTLHG ILSQCSKLQN LSLEGLRLSD PIVNTLAKNS NLVRLNLSGC
SGFSEFALQT LLSSCSRLDE LNLSWCFDFT EKHVQVAVAH VSETITQLNL SGYRKNLQKS
DLSTLVRRCP NLVHLDLSDS VMLKNDCFQE FFQLNYLQHL SLSRCYDIIP ETLLELGEIP
TLKTLQVFGI VPDGTLQLLK EALPHLQINC SHFTTIARPT IGNKKNQEIW GIKCRLTLQK
PSCL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
89	143	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
89	424	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
94	140	Domain	F-box domain	IPR001810	PS50181
97	142	Domain	F-box domain	IPR001810	PF12937
100	140	Domain	F-box domain	IPR001810	SM00256
205	229	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
230	254	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
255	284	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
309	334	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
335	359	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000117
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0070534	protein K63-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:1905168	positive regulation of double-strand break repair via homologous recombination	Biological Process	IEA	GO_REF:0000117
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0000729	DNA double-strand break processing	Biological Process	IDA	PMID:15064416
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0042981	regulation of apoptotic process	Biological Process	IDA	PMID:23277542
GO:0051726	regulation of cell cycle	Biological Process	IEA	GO_REF:0000107
GO:1902916	positive regulation of protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:1990166	protein localization to site of double-strand break	Biological Process	IDA	PMID:24534091
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:27194766
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0048661	positive regulation of smooth muscle cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0070936	protein K48-linked ubiquitination	Biological Process	IMP	PMID:27194766
GO:0071460	cellular response to cell-matrix adhesion	Biological Process	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0016301	kinase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:11931757
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22770219

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL3633439	ChEMBL	6.24	—	—	COc1ccc(S(=O)(=O)Nc2ccc(-c3cccnc3)c3cccnc23)cc1
E3 Binder	CHEMBL3633420	ChEMBL	6.27	—	—	Cc1ccc(S(=O)(=O)Nc2ccc(-c3ccccc3)c3cccnc23)cc1
E3 Binder	CHEMBL3633421	ChEMBL	6.26	—	—	Cc1ccc(S(=O)(=O)Nc2ccc(-c3ccco3)c3cccnc23)cc1
E3 Binder	CHEMBL3633414	ChEMBL	6.08	—	—	Cc1ccc(S(=O)(=O)Nc2ccc(Br)c3cccnc23)cc1
E3 Binder	CHEMBL3633440	ChEMBL	6.77	—	—	O=S(=O)(Nc1ccc(-c2cccnc2)c2cccnc12)c1cccc(C(F)(F)F)c1

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