>Q13191 MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH DHIKVTQEQY ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW QESDGQGCPF CRCEIKGTEP IIVDPFDPRD EGSRCCSIID PFGMPMLDLD DDDDREESLM MNRLANVRKC TDRQNSPVTS PGSSPLAQRR KPQPDPLQIP HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ DKPLPAPPPP LRDPPPPPPE RPPPIPPDNR LSRHIHHVES VPSRDPPMPL EAWCPRDVFG TNQLVGCRLL GEGSPKPGIT ASSNVNGRHS RVGSDPVLMR KHRRHDLPLE GAKVFSNGHL GSEEYDVPPR LSPPPPVTTL LPSIKCTGPL ANSLSEKTRD PVEEDDDEYK IPSSHPVSLN SQPSHCHNVK PPVRSCDNGH CMLNGTHGPS SEKKSNIPDL SIYLKGDVFD SASDPVPLPP ARPPTRDNPK HGSSLNRTPS DYDLLIPPLG EDAFDALPPS LPPPPPPARH SLIEHSKPPG SSSRPSSGQD LFLLPSDPFV DLASGQVPLP PARRLPGENV KTNRTSQDYD QLPSCSDGSQ APARPPKPRP RRTAPEIHHR KPHGPEAALE NVDAKIAKLM GEGYAFEEVK RALEIAQNNV EVARSILREF AFPPPVSPRL NL
The same domains may appear in multiple rows, following InterPro convention.
| Start | End | Type | Name | InterPro | Source |
|---|---|---|---|---|---|
| 1 | 981 | Family | Adaptor protein Cbl | IPR024162 | PTHR23007 |
| 34 | 167 | Homologous_superfamily | Adaptor protein Cbl, N-terminal domain superfamily | IPR036537 | G3DSA:1.20.930.20 |
| 35 | 343 | Domain | Adaptor protein Cbl, PTB domain | IPR024159 | PS51506 |
| 41 | 169 | Homologous_superfamily | Adaptor protein Cbl, N-terminal domain superfamily | IPR036537 | SSF47668 |
| 42 | 167 | Domain | Adaptor protein Cbl, N-terminal helical | IPR003153 | PF02262 |
| 171 | 255 | Homologous_superfamily | EF-hand domain pair | IPR011992 | SSF47473 |
| 171 | 254 | Domain | Adaptor protein Cbl, EF hand-like | IPR014741 | PF02761 |
| 248 | 344 | Domain | Adaptor protein Cbl, SH2-like domain | IPR014742 | cd09920 |
| 256 | 342 | Homologous_superfamily | SH2 domain superfamily | IPR036860 | SSF55550 |
| 256 | 341 | Domain | Adaptor protein Cbl, SH2-like domain | IPR014742 | PF02762 |
| 257 | 342 | Homologous_superfamily | SH2 domain superfamily | IPR036860 | G3DSA:3.30.505.10 |
| 343 | 427 | Homologous_superfamily | Zinc finger, RING/FYVE/PHD-type | IPR013083 | G3DSA:3.30.40.10 |
| 354 | 419 | Domain | E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass | IPR039520 | cd16709 |
| 373 | 411 | Domain | Zinc finger, RING-type | IPR001841 | SM00184 |
| 373 | 412 | Domain | Zinc finger, RING-type | IPR001841 | PS50089 |
| 388 | 397 | Conserved_site | Zinc finger, RING-type, conserved site | IPR017907 | PS00518 |
| 931 | 970 | Domain | Ubiquitin-associated domain | IPR015940 | PS50030 |
| 932 | 969 | Domain | Ubiquitin-associated domain | IPR015940 | SM00165 |
| GO term | Name | Ontology | Evidence | Reference |
|---|---|---|---|---|
| GO:0016567 | protein ubiquitination | Biological Process | IEA | GO_REF:0000041 |
| GO:0007166 | cell surface receptor signaling pathway | Biological Process | IEA | GO_REF:0000002 |
| GO:0023051 | regulation of signaling | Biological Process | IEA | GO_REF:0000002 |
| GO:0002870 | T cell anergy | Biological Process | IEA | GO_REF:0000107 |
| GO:0030163 | protein catabolic process | Biological Process | IEA | GO_REF:0000107 |
| GO:0035739 | CD4-positive, alpha-beta T cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0002669 | positive regulation of T cell anergy | Biological Process | IEA | GO_REF:0000107 |
| GO:0006955 | immune response | Biological Process | IEA | GO_REF:0000107 |
| GO:0030155 | regulation of cell adhesion | Biological Process | IEA | GO_REF:0000107 |
| GO:0031398 | positive regulation of protein ubiquitination | Biological Process | IEA | GO_REF:0000107 |
| GO:0035556 | intracellular signal transduction | Biological Process | IEA | GO_REF:0000107 |
| GO:0042110 | T cell activation | Biological Process | IEA | GO_REF:0000107 |
| GO:0045732 | positive regulation of protein catabolic process | Biological Process | IEA | GO_REF:0000107 |
| GO:0050852 | T cell receptor signaling pathway | Biological Process | IEA | GO_REF:0000107 |
| GO:0050860 | negative regulation of T cell receptor signaling pathway | Biological Process | IEA | GO_REF:0000107 |
| GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | Biological Process | IEA | GO_REF:0000107 |
| GO:0006607 | NLS-bearing protein import into nucleus | Biological Process | TAS | PMID:7784085 |
| GO:0007165 | signal transduction | Biological Process | IBA | GO_REF:0000033 |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | Biological Process | IBA | GO_REF:0000033 |
| GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization | Biological Process | IEA | GO_REF:0000107 |
| GO:0140252 | regulation protein catabolic process at postsynapse | Biological Process | IEA | GO_REF:0000107 |
| GO:2000583 | regulation of platelet-derived growth factor receptor-alpha signaling pathway | Biological Process | ISS | GO_REF:0000024 |
| GO:0005737 | cytoplasm | Cellular Component | IEA | GO_REF:0000120 |
| GO:0005886 | plasma membrane | Cellular Component | IBA | GO_REF:0000033 |
| GO:0045121 | membrane raft | Cellular Component | IBA | GO_REF:0000033 |
| GO:0098794 | postsynapse | Cellular Component | IEA | GO_REF:0000107 |
| GO:0098978 | glutamatergic synapse | Cellular Component | IEA | GO_REF:0000107 |
| GO:0005654 | nucleoplasm | Cellular Component | IDA | GO_REF:0000052 |
| GO:0005829 | cytosol | Cellular Component | IDA | GO_REF:0000052 |
| GO:0061630 | ubiquitin protein ligase activity | Molecular Function | IEA | GO_REF:0000003 |
| GO:0001784 | phosphotyrosine residue binding | Molecular Function | IEA | GO_REF:0000120 |
| GO:0004842 | ubiquitin-protein transferase activity | Molecular Function | IEA | GO_REF:0000002 |
| GO:0005509 | calcium ion binding | Molecular Function | IEA | GO_REF:0000120 |
| GO:0008270 | zinc ion binding | Molecular Function | IEA | GO_REF:0000043 |
| GO:0016740 | transferase activity | Molecular Function | IEA | GO_REF:0000043 |
| GO:0046872 | metal ion binding | Molecular Function | IEA | GO_REF:0000120 |
| GO:0005515 | protein binding | Molecular Function | IPI | PMID:10022120 |
| GO:0030971 | receptor tyrosine kinase binding | Molecular Function | IBA | GO_REF:0000033 |
| Substrate | Name | Known ESI (UbiBrowser) |
Known ESI (UbiNet) |
PPI (IntAct direct) PSI-MI score ≥ 0.5 |
PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs |
PubMed Ref. | IntAct Ref. | Substrate Specificity |
|---|---|---|---|---|---|---|---|---|
| Q13191 | CBLB | Yes | Yes | No | No | — | No | E3-specific |
| P27986 | P85A | Yes | Yes | No | No | — | No | Cluster-specific |
| O00459 | P85B | Yes | Yes | No | No | — | No | E3-specific |
| Type | ChEMBL Compound ID | Source | pChEMBL | PDB Compound ID | PDB Codes | SMILES |
|---|---|---|---|---|---|---|
| E3 Binder | CHEMBL5088894 | ChEMBL | 6.0 | — | — | C=CCC(Sc1nncn1C)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5087335 | ChEMBL | 6.0 | — | — | C=CCC(Sc1nncn1C)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5080479 | ChEMBL | 7.0 | — | — | CC(=O)N1CCN(c2ccc3cnc(C(=O)Nc4cccc([C@H](C)Cc5nncn5C)c4)cc3c2)CC1.O=C(O)C(F)(F)F |
| E3 Binder | CHEMBL4870377 | ChEMBL | 6.12 | — | — | CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(OP(=O)(O)O)cc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(N)=O)[C@@H](C)O |
| E3 Binder | CHEMBL5080328 | ChEMBL | 6.0 | — | — | CC(=O)Nc1ccnc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)c1 |
| E3 Binder | CHEMBL5177770 | ChEMBL | 8.26 | — | — | CC(C)[C@@H]1CN(C)CCN1Cc1cc2c(c(C(F)(F)F)c1)CN(c1cc(C3(Cc4nncn4C)COC3)cc(OC3CCCC3)n1)C2=O |
| E3 Binder | CHEMBL5090112 | ChEMBL | 7.0 | — | — | CC(C)c1cccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)n1 |
| E3 Binder | CHEMBL5081451 | ChEMBL | 6.52 | — | — | CC(C)c1nccc2c1CN(c1cccc([C@H](C)Cc3nncn3C)c1)C2=O |
| E3 Binder | CHEMBL5080287 | ChEMBL | 6.52 | — | — | CC(CO)Nc1cc(C(C)Sc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5088625 | ChEMBL | 6.0 | — | — | CC(Cc1nccn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5089376 | ChEMBL | 6.52 | — | — | CC(Cc1nncn1C)c1cc(C2CCC2)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5085664 | ChEMBL | 7.0 | — | — | CC(Cc1nncn1C)c1cc(F)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088307 | ChEMBL | 6.0 | — | — | CC(Cc1nocc1CO)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5070069 | ChEMBL | 7.0 | — | — | CC(O)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc([C@@](C)(F)C(F)(F)c3nncn3C)c1)C2=O |
| E3 Binder | CHEMBL5091161 | ChEMBL | 6.52 | — | — | CC(Sc1nncn1C)c1cc(F)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5086494 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1cc(NCCO)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5093390 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1ccc(F)c(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5085988 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1ccc(OC(F)(F)F)c(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5085748 | ChEMBL | 6.52 | — | — | CC(Sc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5086089 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1cccc(NC(=O)c2cc3ccc(Cl)cc3cn2)c1 |
| E3 Binder | CHEMBL5090069 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5078010 | ChEMBL | 6.0 | — | — | CC(Sc1nncn1C)c1cccc(NC(=O)c2ccc3c(n2)CCCC3)c1 |
| E3 Binder | CHEMBL5078650 | ChEMBL | 6.52 | — | — | CC(Sc1nncn1C)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5086794 | ChEMBL | 6.52 | — | — | CC(c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)(F)c1nncn1C |
| E3 Binder | CHEMBL5082208 | ChEMBL | 6.52 | — | — | CC(c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)c1nncn1C |
| E3 Binder | CHEMBL5069583 | ChEMBL | 7.0 | — | — | CC(c1cccc(NC(=O)c2ccc(CO)c(C3CC3)n2)c1)C(F)(F)c1nncn1C |
| E3 Binder | CHEMBL5088409 | ChEMBL | 6.52 | — | — | CC(c1nncn1C)C1(c2cccc(N3Cc4c(cc(CN5CCC6(CC6)C5)cc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5072881 | ChEMBL | 7.0 | — | — | CC1CCc2c1n[nH]c2C(=O)Nc1cccc([C@H](C)Cc2nncn2C)c1 |
| E3 Binder | CHEMBL5076117 | ChEMBL | 6.52 | — | — | CC1OCC1Oc1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5086502 | ChEMBL | 6.52 | — | — | CCCOc1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5082645 | ChEMBL | 6.52 | — | — | CCNc1cc(C(C)Sc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5184391 | ChEMBL | 8.19 | — | — | CCNc1cc(N2Cc3c(cc(CNC4(C)CCC4)cc3C(F)(F)F)C2=O)cc(C2(Cc3nncn3C)CC(F)(F)C2)c1 |
| E3 Binder | CHEMBL5178829 | ChEMBL | 8.22 | — | — | CCNc1cc(N2Cc3c(cc(CNC4(C)CCC4)cc3C(F)(F)F)C2=O)cc(C2(Cc3nncn3C)CCC2)c1 |
| E3 Binder | CHEMBL5071247 | ChEMBL | 7.0 | — | — | CCOc1cc(NC(=O)c2cc(C)nc(C3CC3)n2)cc([C@@](C)(F)C(F)(F)c2nncn2C)c1 |
| E3 Binder | CHEMBL5089690 | ChEMBL | 6.0 | — | — | CCOc1cccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)n1 |
| E3 Binder | CHEMBL5074787 | ChEMBL | 6.0 | — | — | CCc1cccc(C(=O)Nc2cc([C@H](C)Sc3nncn3C)ccn2)n1 |
| E3 Binder | CHEMBL5077505 | ChEMBL | 6.52 | — | — | CCn1cnnc1C[C@@H](C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@@H](O)C[C@H]3C)ccn2)c1 |
| E3 Binder | CHEMBL5081087 | ChEMBL | 7.0 | — | — | CN(c1cc2c(c(C(F)(F)F)c1)CN(c1cccc([C@@](C)(F)C(F)(F)c3nncn3C)c1)C2=O)[C@@H]1CNC[C@@H]1F |
| E3 Binder | CHEMBL5078053 | ChEMBL | 7.0 | — | — | CN(c1cc2c(c(C(F)(F)F)c1)CN(c1cccc([C@@](C)(F)C(F)(F)c3nncn3C)c1)C2=O)[C@H]1CNC[C@H]1F |
| E3 Binder | CHEMBL5079179 | ChEMBL | 7.0 | — | — | CN1CCN(c2cc3c(c(C(F)(F)F)c2)CN(c2cccc([C@@](C)(F)C(F)(F)c4nncn4C)c2)C3=O)CC1 |
| E3 Binder | CHEMBL5086040 | ChEMBL | 7.0 | — | — | CNC(=O)COc1ccc2cnc(C(=O)Nc3cccc([C@H](C)Sc4nncn4C)c3)cc2c1 |
| E3 Binder | CHEMBL5077353 | ChEMBL | 6.52 | — | — | CNC(=O)COc1cccc2nc(C(=O)Nc3cccc([C@H](C)Sc4nncn4C)c3)ccc12 |
| E3 Binder | CHEMBL5076510 | ChEMBL | 6.0 | — | — | CNCCNC(=O)c1ccnc(C(=O)Nc2cccc([C@H](C)Cc3nncn3C)c2)c1 |
| E3 Binder | CHEMBL5079169 | ChEMBL | 7.0 | — | — | CNCc1ccc(C(=O)Nc2cccc([C@H]3[C@H](C)[C@H]3c3nncn3C)c2)cc1C1CC1 |
| E3 Binder | CHEMBL5073682 | ChEMBL | 7.0 | — | — | CNS(=O)(=O)c1cc(C(=O)Nc2cccc([C@H](C)Cc3nncn3C)c2)nc(C(F)(F)F)c1 |
| E3 Binder | CHEMBL5083890 | ChEMBL | 6.0 | — | — | CN[C@@H]1CCN(C(=O)c2ccnc(C(=O)Nc3cccc([C@H](C)Cc4nncn4C)c3)c2)C1 |
| E3 Binder | CHEMBL5085720 | ChEMBL | 6.0 | — | — | CN[C@H]1CCN(C(=O)c2ccnc(C(=O)Nc3cccc([C@H](C)Cc4nncn4C)c3)c2)C1 |
| E3 Binder | CHEMBL5081195 | ChEMBL | 6.0 | — | — | CNc1cc(C(C)Sc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5072244 | ChEMBL | 6.0 | — | — | CNc1ccnc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)c1 |
| E3 Binder | CHEMBL5080910 | ChEMBL | 6.0 | — | — | COC(Cc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5091941 | ChEMBL | 6.52 | — | — | COc1cc(C(=O)Nc2cccc([C@H](C)Cc3nncn3C)c2)nc(C(F)(F)F)c1 |
| E3 Binder | CHEMBL5070499 | ChEMBL | 7.0 | — | — | COc1cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc(C(F)(F)F)c1 |
| E3 Binder | CHEMBL5081942 | ChEMBL | 6.0 | — | — | COc1cc(C(F)(F)F)cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)n1 |
| E3 Binder | CHEMBL5091801 | ChEMBL | 7.0 | — | — | COc1ccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5077338 | ChEMBL | 6.0 | — | — | COc1ccc(C(C)Sc2nncn2C)cc1NC(=O)c1ccc2ccccc2n1 |
| E3 Binder | CHEMBL5090435 | ChEMBL | 6.52 | — | — | COc1cccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)n1 |
| E3 Binder | CHEMBL5082295 | ChEMBL | 6.0 | — | — | COc1nc(C(=O)Nc2cc([C@H](C)Sc3nncn3C)ccn2)ccc1Cl |
| E3 Binder | CHEMBL5076700 | ChEMBL | 7.0 | — | — | COc1nc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)cc2ccccc12 |
| E3 Binder | CHEMBL5073173 | ChEMBL | 6.0 | — | — | C[C@@H](Cc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5070012 | ChEMBL | 6.52 | — | — | C[C@@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5074602 | ChEMBL | 6.0 | — | — | C[C@@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL5086153 | ChEMBL | 6.52 | — | — | C[C@@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C3CC3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5093222 | ChEMBL | 7.0 | — | — | C[C@@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5171228 | ChEMBL | 8.24 | — | — | C[C@@H](NC1(C)CCC1)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3(Cc4nncn4C)CC(F)(F)C3)c1)C2=O |
| E3 Binder | CHEMBL5177497 | ChEMBL | 8.17 | — | — | C[C@@H](NC1(C)CCC1)c1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3([C@@H](F)c4nncn4C)COC3)c1)C2=O |
| E3 Binder | CHEMBL5093779 | ChEMBL | 6.0 | — | — | C[C@@H](Sc1nncn1C)c1cc(F)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076039 | ChEMBL | 6.0 | — | — | C[C@@H](Sc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5083391 | ChEMBL | 6.0 | — | — | C[C@@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5087734 | ChEMBL | 7.0 | — | — | C[C@@H](c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)(F)c1nncn1C |
| E3 Binder | CHEMBL5091382 | ChEMBL | 7.0 | — | — | C[C@@H](c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)[C@@H](F)c1nncn1C |
| E3 Binder | CHEMBL5085108 | ChEMBL | 7.0 | — | — | C[C@@H](c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)[C@H](F)c1nncn1C |
| E3 Binder | CHEMBL5083931 | ChEMBL | 7.0 | — | — | C[C@H](CO)Nc1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5083768 | ChEMBL | 6.0 | — | — | C[C@H](Cc1n[nH]cc1CO)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076151 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nccn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5077472 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nccn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5088527 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nnc[nH]1)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5083064 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(-c2cn[nH]c2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076071 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(-c2cncs2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5093826 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(C2=CCOCC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080596 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(C2CCOC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5078251 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(C2CCOCC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5070829 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cc(N2Cc3c(cccc3C(F)(F)F)C2=O)ccc1F |
| E3 Binder | CHEMBL5079854 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(N2Cc3c(cccc3C(F)(F)F)C2=O)nc(C2(C)CC2)c1 |
| E3 Binder | CHEMBL5092603 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(NC2(C)COC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5093172 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(NC2CCC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5079687 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(NC2CCC2O)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088718 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(NC2COC2)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5075487 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(NC2COC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5086758 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(NCCO)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5089312 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(N[C@@H](C)CO)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5079897 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(N[C@@H]2CCOC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5081892 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(N[C@H]2CCOC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5069885 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cc(OC2COC2)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5091852 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cc(OCCO)nc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088567 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(Br)cccc3C2=O)c1 |
| E3 Binder | CHEMBL5083114 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc(C(=O)N4CC(O)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076824 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc(C(=O)N4CC[C@H](O)C4)cc3C3CC3)C2=O)c1 |
| E3 Binder | CHEMBL5086003 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc(C(=O)O)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5085450 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc(C(C)(C)O)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5073280 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc(C4CC4)nc3C3CC3)C2=O)c1 |
| E3 Binder | CHEMBL5084791 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc([C@@H]4CCCNC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088226 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cc([C@H]4CCCNC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5070348 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1.Cl |
| E3 Binder | CHEMBL5072531 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(ccnc3C(C)(C)F)C2=O)c1 |
| E3 Binder | CHEMBL5078393 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(ccnc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5079567 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(ccnc3C3CC3)C2=O)c1 |
| E3 Binder | CHEMBL5077484 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(N2Cc3c(ccnc3C3CCC3)C2=O)c1 |
| E3 Binder | CHEMBL5079662 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2[nH]nc3c2CCCC3)c1 |
| E3 Binder | CHEMBL5092484 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC(CO)C3)ccn2)c1 |
| E3 Binder | CHEMBL5090881 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC(O)C(C)(C)C3)ccn2)c1 |
| E3 Binder | CHEMBL5079581 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC(O)C(F)(F)C3)ccn2)c1 |
| E3 Binder | CHEMBL5084081 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC(S(C)(=O)=O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5075841 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CCC(C)(O)CC3)ccn2)c1 |
| E3 Binder | CHEMBL5092942 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CCC(CO)C3)ccn2)c1 |
| E3 Binder | CHEMBL5078242 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CCC(O)C3(C)C)ccn2)c1 |
| E3 Binder | CHEMBL5075387 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@@H](C#N)C3)ccn2)c1 |
| E3 Binder | CHEMBL5091435 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](C#N)C3)ccn2)c1 |
| E3 Binder | CHEMBL5069653 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)ccc2F)c1 |
| E3 Binder | CHEMBL5082805 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@](C)(N)C3)ccn2)c1 |
| E3 Binder | CHEMBL5080583 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@](C)(O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5088633 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@@H](F)[C@@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5078100 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@@H](O)C[C@H]3C)ccn2)c1 |
| E3 Binder | CHEMBL5093985 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@@H](O)[C@H](F)C3)ccn2)c1 |
| E3 Binder | CHEMBL5083923 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@@H]4[C@@H](O)[C@@H]4C3)ccn2)c1 |
| E3 Binder | CHEMBL5078253 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@H](O)[C@@H](F)C3)ccn2)c1 |
| E3 Binder | CHEMBL5090773 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(C)(C)O)c(Cl)cn2)c1 |
| E3 Binder | CHEMBL5085811 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(C)(C)O)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5070118 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)n[nH]2)c1 |
| E3 Binder | CHEMBL5080358 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(C3(O)COC3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5076757 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(N[C@@H]3CC[C@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5086818 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(N[C@H]3CC[C@@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5076787 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(O[C@@H]3CC[C@@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5085620 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(O[C@@H]3CC[C@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5081014 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(O[C@H]3CC[C@@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5077176 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(S(C)(=O)=O)cc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5093430 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc(S(N)(=O)=O)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5080720 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5081904 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cc3cccn3cn2)c1 |
| E3 Binder | CHEMBL5083648 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(C(C)(C)C)n2)c1 |
| E3 Binder | CHEMBL5093595 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)CO)n2)c1 |
| E3 Binder | CHEMBL5087133 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5075293 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(CCO)n2)c1 |
| E3 Binder | CHEMBL5092337 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cccc(S(C)(=O)=O)n2)c1 |
| E3 Binder | CHEMBL5076829 | ChEMBL | 6.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2ccn(C)n2)c1 |
| E3 Binder | CHEMBL5089546 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2ccn3nccc3n2)c1 |
| E3 Binder | CHEMBL5091738 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2ccnc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5085332 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2ccnc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5071853 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cn3ccnc3cn2)c1 |
| E3 Binder | CHEMBL5079524 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cncc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5087574 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2cnn3cccnc23)c1 |
| E3 Binder | CHEMBL5075576 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2coc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5093648 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2n[nH]c3c2CCC3)c1 |
| E3 Binder | CHEMBL5080753 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2nc(C(F)(F)F)c[nH]2)c1 |
| E3 Binder | CHEMBL5076323 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2nc3c(C(F)(F)F)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5076064 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nncn1C)c1cccc(NC(=O)c2nc3c(C4CC4)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5081059 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1ccnc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5086904 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1ccnc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5085231 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C)c1ccnc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5081286 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncn1C1CC1)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5094156 | ChEMBL | 6.52 | — | — | C[C@H](Cc1nncs1)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5081160 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nocc1C(F)(F)F)c1cccc(N2Cc3c(cc(C(=O)N4CC[C@H](F)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080911 | ChEMBL | 7.0 | — | — | C[C@H](Cc1nocc1C(F)(F)F)c1cccc(N2Cc3c(cc(C(=O)N4CC[C@H](O)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5078503 | ChEMBL | 6.52 | — | — | C[C@H](O)CNc1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5093332 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nnc[nH]1)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5091555 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cc(F)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5073611 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccc(F)c(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5086356 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccc(F)c(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5070292 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccc(F)c(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5094217 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5089389 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(N2Cc3c(ccnc3Cl)C2=O)c1 |
| E3 Binder | CHEMBL5093883 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(N2Cc3cc(Cl)ccc3C2=O)c1 |
| E3 Binder | CHEMBL5093279 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC(O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5076551 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CCC(O)CC3)ccn2)c1 |
| E3 Binder | CHEMBL5084230 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5085414 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@H](O)C[C@@H]3C)ccn2)c1 |
| E3 Binder | CHEMBL5079292 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(=O)N3C[C@H](O)[C@@H](O)C3)ccn2)c1 |
| E3 Binder | CHEMBL5089995 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(C)(C)O)c(Cl)cn2)c1 |
| E3 Binder | CHEMBL5084910 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(C)(C)O)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5087334 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)c(Cl)cn2)c1 |
| E3 Binder | CHEMBL5084834 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)c3ccccc3n2)c1 |
| E3 Binder | CHEMBL5082033 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5073689 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)cc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5084543 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)cc(Cl)n2)c1 |
| E3 Binder | CHEMBL5093434 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C(F)(F)F)ccn2)c1 |
| E3 Binder | CHEMBL5077525 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C3(O)COC3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5082221 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(C3CC3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5076954 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(CCO)ccn2)c1 |
| E3 Binder | CHEMBL5093786 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc(Cl)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5083702 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3c(Cl)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5073017 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3cc(OCC(=O)NCCN)ccc3cn2)c1.Cl |
| E3 Binder | CHEMBL5082720 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3cc(OCC(=O)O)ccc3cn2)c1 |
| E3 Binder | CHEMBL5086377 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3cc(OCc4ccn[nH]4)ccc3cn2)c1 |
| E3 Binder | CHEMBL5083340 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3ccc(OCC(=O)O)cc3cn2)c1 |
| E3 Binder | CHEMBL5091058 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5077495 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc(C#N)c(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5089320 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc(CO)c(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5077820 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5082110 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc(F)c(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5077749 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc3c(OCC(=O)O)cccc3n2)c1 |
| E3 Binder | CHEMBL5093144 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5083317 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(C(C)(F)F)n2)c1 |
| E3 Binder | CHEMBL5077526 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)F)c2F)c1 |
| E3 Binder | CHEMBL5092933 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5088127 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5079579 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(CF)n2)c1 |
| E3 Binder | CHEMBL5074793 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc(S(C)(=O)=O)n2)c1 |
| E3 Binder | CHEMBL5087792 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cccc3scnc23)c1 |
| E3 Binder | CHEMBL5092989 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccnc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5088448 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2ccnc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5093016 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2cncc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5088592 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2nc(C(F)(F)F)ccc2N)c1 |
| E3 Binder | CHEMBL5070504 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1cccc(NC(=O)c2nc(C(F)(F)F)cs2)c1 |
| E3 Binder | CHEMBL5085525 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5077582 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cc(Br)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5077934 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cc(C3CC3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5093907 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cc(Cl)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5079056 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cc(N3CC[C@H](O)C3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5071566 | ChEMBL | 7.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cc3c(C(F)(F)F)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5089137 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2ccc(Cl)c(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5082889 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2ccc3c(n2)CCCC3)c1 |
| E3 Binder | CHEMBL5072332 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2ccc3cccc(F)c3n2)c1 |
| E3 Binder | CHEMBL5083777 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5090445 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cccc(C(C)(C)F)n2)c1 |
| E3 Binder | CHEMBL5076641 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5086311 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cccc(C3CC3)n2)c1 |
| E3 Binder | CHEMBL5086325 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cccc(Cl)n2)c1 |
| E3 Binder | CHEMBL5092035 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2cccc(OC(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5085382 | ChEMBL | 6.0 | — | — | C[C@H](Sc1nncn1C)c1ccnc(NC(=O)c2csc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5091709 | ChEMBL | 6.52 | — | — | C[C@H](Sc1nncn1C1CC1)c1cccc(NC(=O)c2cc3ccccc3cn2)c1 |
| E3 Binder | CHEMBL5088496 | ChEMBL | 6.52 | — | — | Cc1[nH]cnc1CC(C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5079370 | ChEMBL | 7.0 | — | — | Cc1[nH]cnc1C[C@@H](C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076762 | ChEMBL | 7.0 | — | — | Cc1c[nH]nc1-c1cc([C@H](C)Cc2nncn2C)cc(N2Cc3c(cccc3C(F)(F)F)C2=O)n1 |
| E3 Binder | CHEMBL5078511 | ChEMBL | 6.52 | — | — | Cc1c[nH]nc1C[C@H](C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080261 | ChEMBL | 6.0 | — | — | Cc1c[nH]nc1S[C@@H](C)c1ccnc(NC(=O)c2ccc3ccccc3n2)c1 |
| E3 Binder | CHEMBL5078039 | ChEMBL | 6.52 | — | — | Cc1cc(C(=O)Nc2cc([C@H](C)Sc3nncn3C)ccn2)nc(C(F)(F)F)c1 |
| E3 Binder | CHEMBL5078664 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc(-c3c(-c4nncn4C)cnn3C)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5082365 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc(C3(Cc4nncn4C)COC3)c2)n2nc(C(F)(F)F)cc2n1 |
| E3 Binder | CHEMBL5080862 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc(C3(Cc4nncn4C)COC3)c2)n2nc(C)cc2n1 |
| E3 Binder | CHEMBL5086675 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc(C3(Cc4nncn4C)COC3)c2)n2nccc2n1 |
| E3 Binder | CHEMBL5090613 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc(C3=C(c4nncn4C)CCC3)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5075049 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@@H](C)Cc3nncn3C)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5090846 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@@](C)(F)C(F)(F)c3nncn3C)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5079311 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Cc3nncn3C)c2)nc(C(F)(F)F)n1 |
| E3 Binder | CHEMBL5090060 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Cc3nncn3C)c2)nc2ccnn12 |
| E3 Binder | CHEMBL5089798 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Cc3nncs3)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5086154 | ChEMBL | 6.52 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Cc3nocc3C)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5078565 | ChEMBL | 6.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)ccc1Cl |
| E3 Binder | CHEMBL5090534 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc(C(F)(F)F)c1 |
| E3 Binder | CHEMBL5092314 | ChEMBL | 6.52 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc2ccccc12 |
| E3 Binder | CHEMBL5090719 | ChEMBL | 6.52 | — | — | Cc1cc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)ncc1Cl |
| E3 Binder | CHEMBL5071825 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@H]3C[C@H]3c3nncn3C)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5082412 | ChEMBL | 7.0 | — | — | Cc1cc(C(=O)Nc2cccc([C@]3(Cc4nncn4C)CCOC3)c2)nc(C2CC2)n1 |
| E3 Binder | CHEMBL5094681 | ChEMBL | 6.52 | — | — | Cc1cc(C)nc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)c1 |
| E3 Binder | CHEMBL5083021 | ChEMBL | 6.52 | — | — | Cc1cc2c(c(C3CC3)n1)CN(c1cccc([C@H](C)Cc3nncn3C)c1)C2=O |
| E3 Binder | CHEMBL5080084 | ChEMBL | 6.52 | — | — | Cc1ccc(C(=O)Nc2cc([C@H](C)Sc3nncn3C)ccn2)nc1C1CC1 |
| E3 Binder | CHEMBL5079361 | ChEMBL | 7.0 | — | — | Cc1ccc(C(=O)Nc2cccc(C(C)C(F)(F)c3nncn3C)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5079950 | ChEMBL | 6.52 | — | — | Cc1ccc(C(=O)Nc2cccc(C(C)Cc3nccn3C)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5078383 | ChEMBL | 6.52 | — | — | Cc1ccc(C(=O)Nc2cccc([C@H](C)Cc3nnc[nH]3)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5083072 | ChEMBL | 6.52 | — | — | Cc1ccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc1C |
| E3 Binder | CHEMBL5088666 | ChEMBL | 7.0 | — | — | Cc1ccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc1C(F)(F)F |
| E3 Binder | CHEMBL5076526 | ChEMBL | 7.0 | — | — | Cc1ccc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5086220 | ChEMBL | 6.52 | — | — | Cc1cccc2nc(C(=O)Nc3cccc([C@H](C)Sc4nncn4C)c3)ccc12 |
| E3 Binder | CHEMBL5079380 | ChEMBL | 6.52 | — | — | Cc1ccnn1CC(C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5090678 | ChEMBL | 6.0 | — | — | Cc1cnc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)cc1C |
| E3 Binder | CHEMBL5089235 | ChEMBL | 6.0 | — | — | Cc1cncc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)n1 |
| E3 Binder | CHEMBL5084091 | ChEMBL | 6.52 | — | — | Cc1cnn2c(C(=O)Nc3cccc(C4(Cc5nncn5C)COC4)c3)cc(C(F)(F)F)nc12 |
| E3 Binder | CHEMBL5083486 | ChEMBL | 6.52 | — | — | Cc1cnnn1CC(C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5078613 | ChEMBL | 7.0 | — | — | Cc1cnnn1C[C@@H](C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5093232 | ChEMBL | 6.0 | — | — | Cc1cnnn1C[C@H](C)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5090951 | ChEMBL | 6.52 | — | — | Cc1conc1CC(C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088937 | ChEMBL | 7.0 | — | — | Cc1conc1C[C@@H](C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5094036 | ChEMBL | 7.0 | — | — | Cc1conc1C[C@@H](C)c1cccc(NC(=O)c2ccnc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5092676 | ChEMBL | 6.0 | — | — | Cc1conc1C[C@H](C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5071228 | ChEMBL | 7.0 | — | — | Cc1nc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)ccc1Cl |
| E3 Binder | CHEMBL5079015 | ChEMBL | 6.0 | — | — | Cc1nc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)cs1 |
| E3 Binder | CHEMBL5086069 | ChEMBL | 6.52 | — | — | Cc1nc2cc([C@H](C)Sc3nncn3C)cc(NC(=O)c3cccc(C(F)(F)F)n3)c2o1 |
| E3 Binder | CHEMBL5078470 | ChEMBL | 7.0 | — | — | Cc1ncc(C(=O)Nc2cccc([C@H](C)Sc3nncn3C)c2)nc1C1CC1 |
| E3 Binder | CHEMBL5078126 | ChEMBL | 7.0 | — | — | Cn1cnnc1-c1cnn(C)c1-c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5079366 | ChEMBL | 6.52 | — | — | Cn1cnnc1C(F)(F)C(C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5092156 | ChEMBL | 6.0 | — | — | Cn1cnnc1C(F)(F)C(C)(O)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5078009 | ChEMBL | 6.52 | — | — | Cn1cnnc1C(F)(F)[C@@](C)(F)c1cccc(N2Cc3c(cc(CN4CC[C@H](F)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5089037 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cc(-c4cncc(F)c4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5089193 | ChEMBL | 6.52 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cc(C(=O)N4CC(C(F)F)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5076102 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cc(C(=O)N4CC[C@H](O)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5090578 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cc(CN4CC(C#N)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5077962 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cc(CN4CC(F)C4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5084157 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5087032 | ChEMBL | 7.0 | — | — | Cn1cnnc1C(F)(F)[C@](C)(F)c1cccc(NC(=O)c2nc3c(C(F)(F)F)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5071043 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC(C)(C)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5075034 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC(C)(C)c1cccc(NC(=O)c2cc(C(=O)N3CC[C@H](O)C3)cc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5083287 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC(C)(C)c1cccc(NC(=O)c2ccnc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5080606 | ChEMBL | 6.52 | — | — | Cn1cnnc1CC(c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)(F)F |
| E3 Binder | CHEMBL5188760 | ChEMBL | 8.25 | — | — | Cn1cnnc1CC1(c2cc(C3CC3)nc(N3Cc4c(cc(CNC5(C)CCC5)cc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5086498 | ChEMBL | 6.52 | — | — | Cn1cnnc1CC1(c2cccc(N3Cc4c(cc(C(F)(F)C(=O)O)cc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5092415 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC1(c2cccc(N3Cc4c(cc(C5=CN6CCC5CC6)cc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5080907 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC1(c2cccc(N3Cc4c(ccc(F)c4C4CC4)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5094882 | ChEMBL | 6.0 | — | — | Cn1cnnc1CC1(c2cccc(N3Cc4c(cccc4C(F)(F)F)C3=O)c2)CC1 |
| E3 Binder | CHEMBL5070842 | ChEMBL | 6.52 | — | — | Cn1cnnc1CC1(c2cccc(N3Cc4c(cccc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5091431 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC1(c2cccc(NC(=O)c3ccnc(C(F)(F)F)n3)c2)COC1 |
| E3 Binder | CHEMBL5077680 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC1(c2cccc(NC(=O)c3ccnc4ccnn34)c2)COC1 |
| E3 Binder | CHEMBL5083553 | ChEMBL | 7.0 | — | — | Cn1cnnc1CC1(c2cccc(NC(=O)c3csc(C4CC4)n3)c2)COC1 |
| E3 Binder | CHEMBL5081360 | ChEMBL | 6.52 | — | — | Cn1cnnc1CC1(c2cccc(NC(=O)c3nc(C(F)(F)F)cs3)c2)COC1 |
| E3 Binder | CHEMBL5076188 | ChEMBL | 6.52 | — | — | Cn1cnnc1CC1(c2cccc(NC(=O)c3nc(C4CC4)cs3)c2)COC1 |
| E3 Binder | CHEMBL5094009 | ChEMBL | 6.0 | — | — | Cn1cnnc1C[C@@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080144 | ChEMBL | 7.0 | — | — | Cn1cnnc1C[C@H](c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)(F)F |
| E3 Binder | CHEMBL5080902 | ChEMBL | 7.0 | — | — | Cn1cnnc1C[C@H](c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1)C(F)F |
| E3 Binder | CHEMBL5084821 | ChEMBL | 7.0 | — | — | Cn1cnnc1C[C@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5090140 | ChEMBL | 7.0 | — | — | Cn1cnnc1C[C@]1(c2cccc(N3Cc4c(cccc4C(F)(F)F)C3=O)c2)C[C@H](CO)C1 |
| E3 Binder | CHEMBL5080611 | ChEMBL | 7.0 | — | — | Cn1cnnc1OC1(c2cccc(N3Cc4c(cc(CN5CCC(F)CC5)cc4C(F)(F)F)C3=O)c2)COC1 |
| E3 Binder | CHEMBL5080052 | ChEMBL | 6.0 | — | — | Cn1cnnc1SC(CCO)c1cccc(NC(=O)c2cccc(C(F)(F)F)n2)c1 |
| E3 Binder | CHEMBL5087278 | ChEMBL | 6.0 | — | — | Cn1cnnc1[C@@H](F)[C@@](C)(F)c1cccc(N2Cc3c(cc(C4CC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5094574 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@@H](F)[C@@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080412 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@@H](F)[C@](C)(F)c1cccc(N2Cc3c(cc(C4CC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5085827 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@@H](F)[C@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5082897 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@@H]1CC[C@@H]1c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5084293 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@@H]1C[C@@H]1c1cccc(N2Cc3c(cc(C#N)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5082809 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@@H]1C[C@@H]1c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5082851 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@@H]1C[C@@H]1c1cccc(N2Cc3c(ccnc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5088973 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@@H]1C[C@@H]1c1cccc(NC(=O)c2nc3c(C(F)(F)F)cccc3[nH]2)c1 |
| E3 Binder | CHEMBL5085551 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@H](F)[C@@](C)(F)c1cccc(N2Cc3c(cc(C4CC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5094612 | ChEMBL | 6.0 | — | — | Cn1cnnc1[C@H](F)[C@@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5081938 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@H](F)[C@](C)(F)c1cccc(N2Cc3c(cc(C4CC4)cc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5075844 | ChEMBL | 7.0 | — | — | Cn1cnnc1[C@H](F)[C@](C)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5092831 | ChEMBL | 6.0 | — | — | Cn1cnnc1[C@H](O)[C@@H](O)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |
| E3 Binder | CHEMBL5080552 | ChEMBL | 6.52 | — | — | Cn1cnnc1[C@H]1CC[C@H]1c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1 |