RLF

Details:

UniProt Entry: Q13129
Gene: RLF
Class: RING
Family: RING10
Protein length: 1914
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q13129
MADGKGDAAA VAGAGAEAPA VAGAGDGVET ESMVRGHRPV SPAPGASGLR PCLWQLETEL
REQEVSEVSS LNYCRSFCQT LLQYASNKNA SEHIVYLLEV YRLAIQSFAS ARPYLTTECE
DVLLVLGRLV LSCFELLLSV SESELPCEVW LPFLQSLQES HDALLEFGNN NLQILVHVTK
EGVWKNPVLL KILSQQPVET EEVNKLIAQE GPSFLQMRIK HLLKSNCIPQ ATALSKLCAE
SKEISNVSSF QQAYITCLCS MLPNEDAIKE IAKVDCKEVL DIICNLESEG QDNTAFVLCT
TYLTQQLQTA SVYCSWELTL FWSKLQRRID PSLDTFLERC RQFGVIAKTQ QHLFCLIRVI
QTEAQDAGLG VSILLCVRAL QLRSSEDEEM KASVCKTIAC LLPEDLEVRR ACQLTEFLIE
PSLDGFNMLE ELYLQPDQKF DEENAPVPNS LRCELLLALK AHWPFDPEFW DWKTLKRHCH
QLLGQEASDS DDDLSGYEMS INDTDVLESF LSDYDEGKED KQYRRRDLTD QHKEKRDKKP
IGSSERYQRW LQYKFFCLLC KRECIEARIL HHSKMHMEDG IYTCPVCIKK FKRKEMFVPH
VMEHVKMPPS RRDRSKKKLL LKGSQKGICP KSPSAIPEQN HSLNDQAKGE SHEYVTFSKL
EDCHLQDRDL YPCPGTDCSR VFKQFKYLSV HLKAEHQNND ENAKHYLDMK NRREKCTYCR
RHFMSAFHLR EHEQVHCGPQ PYMCVSIDCY ARFGSVNELL NHKQKHDDLR YKCELNGCNI
VFSDLGQLYH HEAQHFRDAS YTCNFLGCKK FYYSKIEYQN HLSMHNVENS NGDIKKSVKL
EESATGEKQD CINQPHLLNQ TDKSHLPEDL FCAESANSQI DTETAENLKE NSDSNSSDQL
SHSSSASMNE ELIDTLDHSE TMQDVLLSNE KVFGPSSLKE KCSSMAVCFD GTKFTCGFDG
CGSTYKNARG MQKHLRKVHP YHFKPKKIKT KDLFPSLGNE HNQTTEKLDA EPKPCSDTNS
DSPDEGLDHN IHIKCKREHQ GYSSESSICA SKRPCTEDTM LELLLRLKHL SLKNSITHGS
FSGSLQGYPS SGAKSLQSVS SISDLNFQNQ DENMPSQYLA QLAAKPFFCE LQGCKYEFVT
REALLMHYLK KHNYSKEKVL QLTMFQHRYS PFQCHICQRS FTRKTHLRIH YKNKHQIGSD
RATHKLLDNE KCDHEGPCSV DRLKGDCSAE LGGDPSSNSE KPHCHPKKDE CSSETDLESS
CEETESKTSD ISSPIGSHRE EQEGREGRGS RRTVAKGNLC YILNKYHKPF HCIHKTCNSS
FTNLKGLIRH YRTVHQYNKE QLCLEKDKAR TKRELVKCKK IFACKYKECN KRFLCSKALA
KHCSDSHNLD HIEEPKVLSE AGSAARFSCN QPQCPAVFYT FNKLKHHLME QHNIEGEIHS
DYEIHCDLNG CGQIFTHRSN YSQHVYYRHK DYYDDLFRSQ KVANERLLRS EKVCQTADTQ
GHEHQTTRRS FNAKSKKCGL IKEKKAPISF KTRAEALHMC VEHSEHTQYP CMVQGCLSVV
KLESSIVRHY KRTHQMSSAY LEQQMENLVV CVKYGTKIKE EPPSEADPCI KKEENRSCES
ERTEHSHSPG DSSAPIQNTD CCHSSERDGG QKGCIESSSV FDADTLLYRG TLKCNHSSKT
TSLEQCNIVQ PPPPCKIENS IPNPNGTESG TYFTSFQLPL PRIKESETRQ HSSGQENTVK
NPTHVPKENF RKHSQPRSFD LKTYKPMGFE SSFLKFIQES EEKEDDFDDW EPSEHLTLSN
SSQSSNDLTG NVVANNMVND SEPEVDIPHS SSDSTIHENL TAIPPLIVAE TTTVPSLENL
RVVLDKALTD CGELALKQLH YLRPVVVLER SKFSTPILDL FPTKKTDELC VGSS

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
555	576	Domain	Zinc finger C2H2-type	IPR013087	SM00355
582	604	Domain	Zinc finger C2H2-type	IPR013087	SM00355
582	609	Domain	Zinc finger C2H2-type	IPR013087	PS50157
584	604	Domain	Zinc finger C2H2-type	IPR013087	PS00028
671	696	Domain	Zinc finger C2H2-type	IPR013087	SM00355
671	701	Domain	Zinc finger C2H2-type	IPR013087	PS50157
673	696	Domain	Zinc finger C2H2-type	IPR013087	PS00028
714	741	Domain	Zinc finger C2H2-type	IPR013087	PS50157
714	736	Domain	Zinc finger C2H2-type	IPR013087	SM00355
716	736	Domain	Zinc finger C2H2-type	IPR013087	PS00028
723	778	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
742	771	Domain	Zinc finger C2H2-type	IPR013087	PS50157
742	766	Domain	Zinc finger C2H2-type	IPR013087	SM00355
744	766	Domain	Zinc finger C2H2-type	IPR013087	PS00028
771	800	Domain	Zinc finger C2H2-type	IPR013087	PS50157
771	795	Domain	Zinc finger C2H2-type	IPR013087	SM00355
773	795	Domain	Zinc finger C2H2-type	IPR013087	PS00028
801	830	Domain	Zinc finger C2H2-type	IPR013087	PS50157
801	825	Domain	Zinc finger C2H2-type	IPR013087	SM00355
803	825	Domain	Zinc finger C2H2-type	IPR013087	PS00028
954	979	Domain	Zinc finger C2H2-type	IPR013087	SM00355
954	979	Domain	Zinc finger C2H2-type	IPR013087	PS50157
956	979	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1127	1152	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1129	1152	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1172	1195	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1172	1195	Domain	Zinc finger C2H2-type	IPR013087	PF00096
1172	1195	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1174	1195	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1310	1335	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1310	1340	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1312	1335	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1362	1392	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1362	1387	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1364	1387	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1407	1432	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1407	1437	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1409	1432	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1444	1469	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1446	1469	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1549	1574	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1551	1574	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0031452	negative regulation of heterochromatin formation	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	ISS	PMID:8545128
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	ISS	PMID:8545128
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	ISS	PMID:8545128
GO:0003677	DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:10545207
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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