TRAF3

>Q13114
MESSKKMDSP GALQTNPPLK LHTDRSAGTP VFVPEQGGYK EKFVKTVEDK YKCEKCHLVL
CSPKQTECGH RFCESCMAAL LSSSSPKCTA CQESIVKDKV FKDNCCKREI LALQIYCRNE
SRGCAEQLML GHLLVHLKND CHFEELPCVR PDCKEKVLRK DLRDHVEKAC KYREATCSHC
KSQVPMIALQ KHEDTDCPCV VVSCPHKCSV QTLLRSELSA HLSECVNAPS TCSFKRYGCV
FQGTNQQIKA HEASSAVQHV NLLKEWSNSL EKKVSLLQNE SVEKNKSIQS LHNQICSFEI
EIERQKEMLR NNESKILHLQ RVIDSQAEKL KELDKEIRPF RQNWEEADSM KSSVESLQNR
VTELESVDKS AGQVARNTGL LESQLSRHDQ MLSVHDIRLA DMDLRFQVLE TASYNGVLIW
KIRDYKRRKQ EAVMGKTLSL YSQPFYTGYF GYKMCARVYL NGDGMGKGTH LSLFFVIMRG
EYDALLPWPF KQKVTLMLMD QGSSRRHLGD AFKPDPNSSS FKKPTGEMNI ASGCPVFVAQ
TVLENGTYIK DDTIFIKVIV DTSDLPDP

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
19	568	Family	TNF receptor-associated factor TRAF, metazoa	IPR012227	PIRSF015614
33	147	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
51	92	Domain	TNF receptor-associated factor 3, C3HC3D-type RING zinc finger	IPR027128	cd16640
53	92	Domain	Zinc finger, RING-type	IPR001841	PS50089
68	77	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
135	190	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
136	192	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
148	196	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
192	249	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
197	258	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
377	568	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
378	563	Domain	TRAF3, MATH domain	IPR037304	cd03777
415	560	Domain	MATH/TRAF domain	IPR002083	PS50144
420	543	Domain	MATH/TRAF domain	IPR002083	SM00061

GO term	Name	Ontology	Evidence	Reference
GO:0001817	regulation of cytokine production	Biological Process	IEA	GO_REF:0000002
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0008063	Toll signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000002
GO:0050688	regulation of defense response to virus	Biological Process	IEA	GO_REF:0000002
GO:0032481	positive regulation of type I interferon production	Biological Process	IDA	PMID:14703513
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:25636800
GO:0002224	toll-like receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0007166	cell surface receptor signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0030162	regulation of proteolysis	Biological Process	IEA	GO_REF:0000120
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IMP	PMID:20185819
GO:0032479	regulation of type I interferon production	Biological Process	IEA	GO_REF:0000117
GO:0032648	regulation of interferon-beta production	Biological Process	ISS	GO_REF:0000024
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process	TAS	Reactome:R-HSA-9013973
GO:0043122	regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0051607	defense response to virus	Biological Process	NAS	PMID:24622840
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	NAS	PMID:25847972
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IC	PMID:16858409
GO:0005768	endosome	Cellular Component	IDA	PMID:18222170
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0010008	endosome membrane	Cellular Component	IDA	PMID:18222170
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-166245
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000117
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:21200404
GO:0035631	CD40 receptor complex	Cellular Component	ISS	GO_REF:0000024
GO:1902554	serine/threonine protein kinase complex	Cellular Component	NAS	PMID:24622840
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000117
GO:0031996	thioesterase binding	Molecular Function	IEA	GO_REF:0000117
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19898473
GO:0005515	protein binding	Molecular Function	IPI	PMID:10791955
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019901	protein kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0019903	protein phosphatase binding	Molecular Function	IPI	PMID:23871208
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P63279	UBC9	Yes	No	No	No	—	No	E3-specific