ZBT17

Details:

UniProt Entry: Q13105

Gene: ZBTB17

Class: RING

Family: RING6

Protein length: 803

Database confidence: 0.375

InterPro: InterPro Entry

Mode of Action: Complex

AlphaFold Model: Link

PDB Structures: 2lvr, 2lvt, 2lvu, 2m0d, 2m0e, 2m0f, 2n25, 2n26, 2q81, 3m52, 4u2m, 4u2n, 5ion, 7azw, 7azx, 7mc1, 7mc2, 7mc3, 7t58

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	149	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
2	109	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	110	Domain	BTB/POZ domain	IPR000210	PF00651
24	116	Domain	BTB/POZ domain	IPR000210	SM00225
24	86	Domain	BTB/POZ domain	IPR000210	PS50097
305	337	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
306	328	Domain	Zinc finger C2H2-type	IPR013087	PF00096
306	333	Domain	Zinc finger C2H2-type	IPR013087	PS50157
306	328	Domain	Zinc finger C2H2-type	IPR013087	SM00355
308	328	Domain	Zinc finger C2H2-type	IPR013087	PS00028
328	380	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
334	361	Domain	Zinc finger C2H2-type	IPR013087	PS50157
334	356	Domain	Zinc finger C2H2-type	IPR013087	SM00355
336	356	Domain	Zinc finger C2H2-type	IPR013087	PS00028
362	384	Domain	Zinc finger C2H2-type	IPR013087	SM00355
362	389	Domain	Zinc finger C2H2-type	IPR013087	PS50157
364	384	Domain	Zinc finger C2H2-type	IPR013087	PS00028
371	427	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
390	412	Domain	Zinc finger C2H2-type	IPR013087	PF00096
390	417	Domain	Zinc finger C2H2-type	IPR013087	PS50157
390	412	Domain	Zinc finger C2H2-type	IPR013087	SM00355
392	412	Domain	Zinc finger C2H2-type	IPR013087	PS00028
417	449	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
418	445	Domain	Zinc finger C2H2-type	IPR013087	PS50157
418	440	Domain	Zinc finger C2H2-type	IPR013087	SM00355
418	440	Domain	Zinc finger C2H2-type	IPR013087	PF00096
420	440	Domain	Zinc finger C2H2-type	IPR013087	PS00028
446	468	Domain	Zinc finger C2H2-type	IPR013087	PF00096
446	473	Domain	Zinc finger C2H2-type	IPR013087	PS50157
446	468	Domain	Zinc finger C2H2-type	IPR013087	SM00355
448	468	Domain	Zinc finger C2H2-type	IPR013087	PS00028
455	511	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
474	501	Domain	Zinc finger C2H2-type	IPR013087	PS50157
474	496	Domain	Zinc finger C2H2-type	IPR013087	SM00355
475	496	Domain	Zinc finger C2H2-type	IPR013087	PF00096
476	496	Domain	Zinc finger C2H2-type	IPR013087	PS00028
502	524	Domain	Zinc finger C2H2-type	IPR013087	SM00355
502	529	Domain	Zinc finger C2H2-type	IPR013087	PS50157
504	524	Domain	Zinc finger C2H2-type	IPR013087	PS00028
511	567	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
530	552	Domain	Zinc finger C2H2-type	IPR013087	SM00355
530	557	Domain	Zinc finger C2H2-type	IPR013087	PS50157
530	552	Domain	Zinc finger C2H2-type	IPR013087	PS00028
531	552	Domain	Zinc finger C2H2-type	IPR013087	PF00096
552	604	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
558	580	Domain	Zinc finger C2H2-type	IPR013087	SM00355
558	580	Domain	Zinc finger C2H2-type	IPR013087	PF00096
558	585	Domain	Zinc finger C2H2-type	IPR013087	PS50157
560	580	Domain	Zinc finger C2H2-type	IPR013087	PS00028
584	638	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
586	608	Domain	Zinc finger C2H2-type	IPR013087	PF00096
586	608	Domain	Zinc finger C2H2-type	IPR013087	SM00355
586	613	Domain	Zinc finger C2H2-type	IPR013087	PS50157
588	608	Domain	Zinc finger C2H2-type	IPR013087	PS00028
614	637	Domain	Zinc finger C2H2-type	IPR013087	PF00096
614	642	Domain	Zinc finger C2H2-type	IPR013087	PS50157
614	637	Domain	Zinc finger C2H2-type	IPR013087	SM00355
616	637	Domain	Zinc finger C2H2-type	IPR013087	PS00028
716	743	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
717	739	Domain	Zinc finger C2H2-type	IPR013087	SM00355
717	744	Domain	Zinc finger C2H2-type	IPR013087	PS50157
719	739	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

Enzyme–Substrate Interactions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0070314	G1 to G0 transition	Biological Process	IDA	PMID:19160485
GO:0001702	gastrulation with mouth forming second	Biological Process	IEA	GO_REF:0000107
GO:0007398	ectoderm development	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000120
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:19160485
GO:0045786	negative regulation of cell cycle	Biological Process	TAS	PMID:12244100
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IMP	PMID:19160485
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:19160485
GO:0032993	protein-DNA complex	Cellular Component	IMP	PMID:19160485
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001046	core promoter sequence-specific DNA binding	Molecular Function	IDA	PMID:19160485
GO:0001223	transcription coactivator binding	Molecular Function	IPI	PMID:19160485
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IMP	PMID:19160485
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IDA	PMID:12244100
GO:0005515	protein binding	Molecular Function	IPI	PMID:12244100
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IPI	PMID:19160485

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