MKRN3

Details:

UniProt Entry: Q13064
Gene: MKRN3
Class: RING
Family: RING1
Protein length: 507
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q13064
MEEPAAPSEA HEAAGAQAGA EAAREGVSGP DLPVCEPSGE SAAPDSALPH AARGWAPFPV
APVPAHLRRG GLRPAPASGG GAWPSPLPSR SSGIWTKQII CRYYIHGQCK EGENCRYSHD
LSGRKMATEG GVSPPGASAG GGPSTAAHIE PPTQEVAEAP PAASSLSLPV IGSAAERGFF
EAERDNADRG AAGGAGVESW ADAIEFVPGQ PYRGRWVASA PEAPLQSSET ERKQMAVGSG
LRFCYYASRG VCFRGESCMY LHGDICDMCG LQTLHPMDAA QREEHMRACI EAHEKDMELS
FAVQRGMDKV CGICMEVVYE KANPNDRRFG ILSNCNHSFC IRCIRRWRSA RQFENRIVKS
CPQCRVTSEL VIPSEFWVEE EEEKQKLIQQ YKEAMSNKAC RYFAEGRGNC PFGDTCFYKH
EYPEGWGDEP PGPGGGSFSA YWHQLVEPVR MGEGNMLYKS IKKELVVLRL ASLLFKRFLS
LRDELPFSED QWDLLHYELE EYFNLIL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
95	121	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
95	122	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
96	120	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
100	428	Family	MKRN-like	IPR045072	PTHR11224
100	120	Domain	E3 ligase, CCCH-type zinc finger	IPR041367	PF18044
238	265	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
238	264	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
291	398	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
311	365	Domain	Zinc finger, RING-type	IPR001841	PS50089
311	364	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
311	364	Domain	Zinc finger, RING-type	IPR001841	SM00184
335	344	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
394	423	Domain	Zinc finger, CCCH-type	IPR000571	PS50103
396	422	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
422	506	Domain	E3 ubiquitin-protein ligase makorin 1, C-terminal	IPR031644	PF15815

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:1990904	ribonucleoprotein complex	Cellular Component	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0003723	RNA binding	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22493164

Enzyme–Substrate Interactions ▾


P11940	PABP1	Yes	No	No	No	—	No	Cluster-specific

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