TRI32

>Q13049
MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR
CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC
EPCREADHQP PGHCTLPVKE AAEERRRDFG EKLTRLRELM GELQRRKAAL EGVSKDLQAR
YKAVLQEYGH EERRVQDELA RSRKFFTGSL AEVEKSNSQV VEEQSYLLNI AEVQAVSRCD
YFLAKIKQAD VALLEETADE EEPELTASLP RELTLQDVEL LKVGHVGPLQ IGQAVKKPRT
VNVEDSWAME ATASAASTSV TFREMDMSPE EVVASPRASP AKQRGPEAAS NIQQCLFLKK
MGAKGSTPGM FNLPVSLYVT SQGEVLVADR GNYRIQVFTR KGFLKEIRRS PSGIDSFVLS
FLGADLPNLT PLSVAMNCQG LIGVTDSYDN SLKVYTLDGH CVACHRSQLS KPWGITALPS
GQFVVTDVEG GKLWCFTVDR GSGVVKYSCL CSAVRPKFVT CDAEGTVYFT QGLGLNLENR
QNEHHLEGGF SIGSVGPDGQ LGRQISHFFS ENEDFRCIAG MCVDARGDLI VADSSRKEIL
HFPKGGGYSV LIREGLTCPV GIALTPKGQL LVLDCWDHCI KIYSYHLRRY STP

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
6	94	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
20	62	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
20	64	Domain	Zinc finger, RING-type	IPR001841	SM00184
20	65	Domain	Zinc finger, RING-type	IPR001841	PS50089
39	48	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
95	138	Domain	B-box-type zinc finger	IPR000315	PS50119
95	138	Domain	B-box-type zinc finger	IPR000315	SM00336
98	138	Domain	TRIM32, B-box type 1 zinc finger	IPR047051	cd19806
347	546	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
358	401	Repeat	NHL repeat	IPR001258	PS51125
371	398	Repeat	NHL repeat	IPR001258	PF01436
415	458	Repeat	NHL repeat	IPR001258	PS51125
464	499	Repeat	NHL repeat	IPR001258	PS51125
469	496	Repeat	NHL repeat	IPR001258	PF01436
547	652	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
562	605	Repeat	NHL repeat	IPR001258	PS51125
616	643	Repeat	NHL repeat	IPR001258	PF01436
616	646	Repeat	NHL repeat	IPR001258	PS51125

GO term	Name	Ontology	Evidence	Reference
GO:0000045	autophagosome assembly	Biological Process	IMP	PMID:22170151
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0001894	tissue homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0007014	actin ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0033554	cellular response to stress	Biological Process	IDA	PMID:37943659
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:12471095
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:28898289
GO:0045732	positive regulation of protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0046716	muscle cell cellular homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0051155	positive regulation of striated muscle cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0060271	cilium assembly	Biological Process	IDA	PMID:25552655
GO:0061564	axon development	Biological Process	IEA	GO_REF:0000107
GO:0061824	cytosolic ciliogenesis	Biological Process	IDA	PMID:28498859
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1903883	positive regulation of interleukin-17-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1903886	positive regulation of chemokine (C-C motif) ligand 20 production	Biological Process	IEA	GO_REF:0000107
GO:1905161	protein localization to phagocytic vesicle	Biological Process	IDA	PMID:28898289
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:19349376
GO:0006979	response to oxidative stress	Biological Process	IDA	PMID:37943659
GO:0009411	response to UV	Biological Process	ISS	GO_REF:0000024
GO:0009896	positive regulation of catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0009967	positive regulation of signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0010508	positive regulation of autophagy	Biological Process	IBA	GO_REF:0000033
GO:0010557	positive regulation of macromolecule biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0010994	free ubiquitin chain polymerization	Biological Process	IDA	PMID:31123703
GO:0019725	cellular homeostasis	Biological Process	IEA	GO_REF:0000117
GO:0030307	positive regulation of cell growth	Biological Process	IDA	PMID:18632609
GO:0030335	positive regulation of cell migration	Biological Process	IDA	PMID:18632609
GO:0032897	negative regulation of viral transcription	Biological Process	IDA	PMID:18248090
GO:0034198	cellular response to amino acid starvation	Biological Process	IBA	GO_REF:0000033
GO:0034612	response to tumor necrosis factor	Biological Process	ISS	GO_REF:0000024
GO:0042594	response to starvation	Biological Process	IDA	PMID:37943659
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	ISS	GO_REF:0000024
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	TAS	PMID:16175175
GO:0045444	fat cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045666	positive regulation of neuron differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045787	positive regulation of cell cycle	Biological Process	IDA	PMID:18632609
GO:0045862	positive regulation of proteolysis	Biological Process	IDA	PMID:18632609
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0048147	negative regulation of fibroblast proliferation	Biological Process	ISS	GO_REF:0000024
GO:0050769	positive regulation of neurogenesis	Biological Process	ISS	GO_REF:0000024
GO:0051247	positive regulation of protein metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:37943659
GO:1902018	negative regulation of cilium assembly	Biological Process	IDA	PMID:28498859
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Biological Process	IDA	PMID:18632609
GO:2000147	positive regulation of cell motility	Biological Process	ISS	GO_REF:0000024
GO:2000786	positive regulation of autophagosome assembly	Biological Process	IDA	PMID:37943659
GO:0005863	striated muscle myosin thick filament	Cellular Component	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005776	autophagosome	Cellular Component	IDA	PMID:37943659
GO:0005813	centrosome	Cellular Component	IDA	PMID:28498859
GO:0005634	nucleus	Cellular Component	ISS	GO_REF:0000024
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000120
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1964496
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0003723	RNA binding	Molecular Function	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0017022	myosin binding	Molecular Function	ISS	GO_REF:0000024
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IDA	PMID:28898289
GO:0030957	Tat protein binding	Molecular Function	TAS	PMID:16175175
GO:0031369	translation initiation factor binding	Molecular Function	ISS	GO_REF:0000024
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000120
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:19349376
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96EV8	DTBP1	Yes	Yes	No	No	28514442	EBI-21651992	E3-specific
Q96BN8	OTUL	Yes	No	No	No	—	No	E3-specific
P17661	DESM	Yes	Yes	No	No	—	No	E3-specific
Q9H9R9	DBND1	Yes	Yes	No	No	—	No	E3-specific
Q9BXC9	BBS2	Yes	Yes	No	No	—	No	E3-specific
Q13049	TRI32	Yes	Yes	Yes	Yes	25416956, 22493164, 32296183	EBI-4307320	E3-specific
Q8N2W9	PIAS4	Yes	Yes	No	No	—	No	E3-specific
Q9NYB9	ABI2	Yes	Yes	Yes	No	29892012, 25416956, 32296183, 28514442, 31515488, 25910212	EBI-22463031	E3-specific