NFX1

Details:

UniProt Entry: Q12986
Gene: NFX1
Class: RING
Family: RING9
Protein length: 1120
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q12986
MAEAPPVSGT FKFNTDAAEF IPQEKKNSGL NCGTQRRLDS NRIGRRNYSS PPPCHLSRQV
PYDEISAVHQ HSYHPSGSKP KSQQTSFQSS PCNKSPKSHG LQNQPWQKLR NEKHHIRVKK
AQSLAEQTSD TAGLESSTRS ESGTDLREHS PSESEKEVVG ADPRGAKPKK ATQFVYSYGR
GPKVKGKLKC EWSNRTTPKP EDAGPESTKP VGVFHPDSSE ASSRKGVLDG YGARRNEQRR
YPQKRPPWEV EGARPRPGRN PPKQEGHRHT NAGHRNNMGP IPKDDLNERP AKSTCDSENL
AVINKSSRRV DQEKCTVRRQ DPQVVSPFSR GKQNHVLKNV ETHTGSLIEQ LTTEKYECMV
CCELVRVTAP VWSCQSCYHV FHLNCIKKWA RSPASQADGQ SGWRCPACQN VSAHVPNTYT
CFCGKVKNPE WSRNEIPHSC GEVCRKKQPG QDCPHSCNLL CHPGPCPPCP AFMTKTCECG
RTRHTVRCGQ AVSVHCSNPC ENILNCGQHQ CAELCHGGQC QPCQIILNQV CYCGSTSRDV
LCGTDVGKSD GFGDFSCLKI CGKDLKCGNH TCSQVCHPQP CQQCPRLPQL VRCCPCGQTP
LSQLLELGSS SRKTCMDPVP SCGKVCGKPL PCGSLDFIHT CEKLCHEGDC GPCSRTSVIS
CRCSFRTKEL PCTSLKSEDA TFMCDKRCNK KRLCGRHKCN EICCVDKEHK CPLICGRKLR
CGLHRCEEPC HRGNCQTCWQ ASFDELTCHC GASVIYPPVP CGTRPPECTQ TCARVHECDH
PVYHSCHSEE KCPPCTFLTQ KWCMGKHEFR SNIPCHLVDI SCGLPCSATL PCGMHKCQRL
CHKGECLVDE PCKQPCTTPR ADCGHPCMAP CHTSSPCPVT ACKAKVELQC ECGRRKEMVI
CSEASSTYQR IAAISMASKI TDMQLGGSVE ISKLITKKEV HQARLECDEE CSALERKKRL
AEAFHISEDS DPFNIRSSGS KFSDSLKEDA RKDLKFVSDV EKEMETLVEA VNKGKNSKKS
HSFPPMNRDH RRIIHDLAQV YGLESVSYDS EPKRNVVVTA IRGKSVCPPT TLTGVLEREM
QARPPPPIPH HRHQSDKNPG SSNLQKITKE PIIDYFDVQD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
170	1086	Family	Transcription factor NFX1 family	IPR034078	PTHR12360
355	411	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
358	408	Domain	Zinc finger, RING-type	IPR001841	SM00184
358	409	Domain	Zinc finger, RING-type	IPR001841	PS50089
453	471	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
455	470	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
506	524	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
506	525	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
567	586	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
567	585	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
632	654	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
632	655	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
694	713	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
694	704	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
721	740	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
721	739	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
778	797	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
832	854	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
832	853	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
863	882	Domain	Zinc finger, NF-X1-type	IPR000967	PF01422
863	884	Domain	Zinc finger, NF-X1-type	IPR000967	SM00438
969	1096	Homologous_superfamily	R3H domain superfamily	IPR036867	SSF82708
983	1061	Domain	R3H domain	IPR001374	SM00393
987	1065	Homologous_superfamily	R3H domain superfamily	IPR036867	G3DSA:3.30.1370.50
987	1060	Domain	Transcriptional repressor NF-X1, R3H domain	IPR034076	cd02643
994	1062	Domain	R3H domain	IPR001374	PS51061
995	1059	Domain	R3H domain	IPR001374	PF01424

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0045347	negative regulation of MHC class II biosynthetic process	Biological Process	IEA	GO_REF:0000107
GO:0006366	transcription by RNA polymerase II	Biological Process	TAS	PMID:7964459
GO:0006954	inflammatory response	Biological Process	TAS	PMID:7964459
GO:0016567	protein ubiquitination	Biological Process	TAS	PMID:15371341
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:10500182
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:7964459
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:10500182

Enzyme–Substrate Interactions ▾

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