TRAF2

>Q12933
MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE
YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE
VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL
REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA
EACSRQHRLD QDKIEALSSK VQQLERSIGL KDLAMADLEQ KVLEMEASTY DGVFIWKISD
FARKRQEAVA GRIPAIFSPA FYTSRYGYKM CLRIYLNGDG TGRGTHLSLF FVVMKGPNDA
LLRWPFNQKV TLMLLDQNNR EHVIDAFRPD VTSSSFQRPV NDMNIASGCP LFCPVSKMEA
KNSYVRDDAI FIKAIVDLTG L

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	137	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
3	501	Family	TNF receptor-associated factor TRAF, metazoa	IPR012227	PIRSF015614
32	73	Domain	TNF receptor-associated factor 2, C3HC3D-type RING zinc finger	IPR027133	cd16639
34	72	Domain	Zinc finger, RING-type	IPR001841	SM00184
34	72	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
34	72	Domain	Zinc finger, RING-type	IPR001841	PS50089
49	58	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
125	170	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
138	181	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
177	233	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
178	235	Domain	Zinc finger, TRAF-type	IPR001293	PF02176
182	240	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
267	330	Domain	TNF receptor-associated factor, BIRC3 binding domain	IPR032070	PF16673
332	501	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10
334	497	Domain	TNF receptor-associated factor 2, MATH domain	IPR037305	cd03778
351	496	Domain	MATH/TRAF domain	IPR002083	PS50144
356	478	Domain	MATH/TRAF domain	IPR002083	SM00061

GO term	Name	Ontology	Evidence	Reference
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0002700	regulation of production of molecular mediator of immune response	Biological Process	IEA	GO_REF:0000117
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0010628	positive regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0012501	programmed cell death	Biological Process	IEA	GO_REF:0000117
GO:0042981	regulation of apoptotic process	Biological Process	IEA	GO_REF:0000002
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0043408	regulation of MAPK cascade	Biological Process	IEA	GO_REF:0000117
GO:0046328	regulation of JNK cascade	Biological Process	IEA	GO_REF:0000002
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0070534	protein K63-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:1905669	TORC1 complex assembly	Biological Process	IEA	GO_REF:0000117
GO:1905670	TORC2 complex disassembly	Biological Process	IEA	GO_REF:0000117
GO:0002637	regulation of immunoglobulin production	Biological Process	IEA	GO_REF:0000107
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:26678875
GO:0038203	TORC2 signaling	Biological Process	IDA	PMID:35926713
GO:0042110	T cell activation	Biological Process	IDA	PMID:38354704
GO:0071732	cellular response to nitric oxide	Biological Process	IEA	GO_REF:0000107
GO:0097300	programmed necrotic cell death	Biological Process	IEA	GO_REF:0000107
GO:0160162	CD27 signaling pathway	Biological Process	IDA	PMID:38354704
GO:0045087	innate immune response	Biological Process	IDA	PMID:23951545
GO:0002726	positive regulation of T cell cytokine production	Biological Process	IMP	PMID:15125833
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0023019	signal transduction involved in regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0023035	CD40 signaling pathway	Biological Process	IDA	PMID:15708970
GO:0032743	positive regulation of interleukin-2 production	Biological Process	IMP	PMID:15125833
GO:0034351	negative regulation of glial cell apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0034976	response to endoplasmic reticulum stress	Biological Process	NAS	PMID:10650002
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:8565075
GO:0043254	regulation of protein-containing complex assembly	Biological Process	IMP	PMID:11278723
GO:0043507	positive regulation of JUN kinase activity	Biological Process	IDA	PMID:11907583
GO:0048255	mRNA stabilization	Biological Process	IEA	GO_REF:0000107
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IMP	PMID:15121867
GO:0065003	protein-containing complex assembly	Biological Process	ISS	GO_REF:0000024
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Biological Process	TAS	PMID:14685163
GO:0097400	interleukin-17-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:21525013
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0043235	receptor complex	Cellular Component	IEA	GO_REF:0000117
GO:1990604	IRE1-TRAF2-ASK1 complex	Cellular Component	IEA	GO_REF:0000117
GO:0009898	cytoplasmic side of plasma membrane	Cellular Component	IC	PMID:8565075
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-8862184
GO:0005938	cell cortex	Cellular Component	IEA	GO_REF:0000107
GO:0012506	vesicle membrane	Cellular Component	IEA	GO_REF:0000107
GO:0045121	membrane raft	Cellular Component	IEA	GO_REF:0000107
GO:0000151	ubiquitin ligase complex	Cellular Component	IPI	PMID:17314283
GO:0002947	tumor necrosis factor receptor superfamily complex	Cellular Component	IDA	PMID:23429285
GO:0032991	protein-containing complex	Cellular Component	IEA	GO_REF:0000107
GO:0035631	CD40 receptor complex	Cellular Component	ISS	GO_REF:0000024
GO:0097057	TRAF2-GSTP1 complex	Cellular Component	IDA	PMID:16636664
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0019899	enzyme binding	Molecular Function	IEA	GO_REF:0000117
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008289	lipid binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IEA	GO_REF:0000117
GO:0032813	tumor necrosis factor receptor superfamily binding	Molecular Function	IEA	GO_REF:0000117
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005174	CD40 receptor binding	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:10075662
GO:0019901	protein kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0019903	protein phosphatase binding	Molecular Function	IPI	PMID:15696169
GO:0031435	mitogen-activated protein kinase kinase kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:11279055
GO:0031996	thioesterase binding	Molecular Function	IPI	PMID:11279055
GO:0035591	signaling adaptor activity	Molecular Function	IBA	GO_REF:0000033
GO:0043120	tumor necrosis factor binding	Molecular Function	IPI	PMID:23429285
GO:0044877	protein-containing complex binding	Molecular Function	IEA	GO_REF:0000120
GO:0046625	sphingolipid binding	Molecular Function	IDA	PMID:20577214

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P00966	ASSY	Yes	No	No	No	—	No	E3-specific
Q13627	DYR1A	Yes	No	Yes	No	35914814, 30561431	EBI-20736875	E3-specific
Q15759	MK11	Yes	No	No	No	—	No	E3-specific