TRI26

Details:

UniProt Entry: Q12899
Gene: TRIM26
Class: RING
Family: RING5
Protein length: 539
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q12899
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL
CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK
LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS
ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF
QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS
KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG
DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL
FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	85	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
97	138	Domain	B-box-type zinc finger	IPR000315	PS50119
97	138	Domain	B-box-type zinc finger	IPR000315	SM00336
99	136	Domain	B-box-type zinc finger	IPR000315	PF00643
294	384	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
295	539	Domain	B30.2/SPRY domain	IPR001870	PS50188
306	378	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
311	328	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
312	364	Domain	SPRY-associated	IPR006574	SM00589
315	363	Domain	SPRY-associated	IPR006574	PF13765
328	345	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
350	374	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
365	539	Domain	SPRY domain	IPR003877	SM00449
428	538	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
435	530	Domain	SPRY domain	IPR003877	PF00622
436	532	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
437	450	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
480	504	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
510	528	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:19675569
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:16260783
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:12676957
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:29203640
GO:0044790	suppression of viral release by host	Biological Process	IDA	PMID:18248090
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IBA	GO_REF:0000033
GO:0070979	protein K11-linked ubiquitination	Biological Process	IDA	PMID:34017102
GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:34017102
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005634	nucleus	Cellular Component	IDA	PMID:25763818
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:21516116
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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