CHD3

Details:

UniProt Entry: Q12873
Gene: CHD3
Class: RING
Family: RING10
Protein length: 2000
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q12873
MKAADTVILW ARSKNDQLRI SFPPGLCWGD RMPDKDDIRL LPSALGVKKR KRGPKKQKEN
KPGKPRKRKK RDSEEEFGSE RDEYREKSES GGSEYGTGPG RKRRRKHREK KEKKTKRRKK
GEGDGGQKQV EQKSSATLLL TWGLEDVEHV FSEEDYHTLT NYKAFSQFMR PLIAKKNPKI
PMSKMMTILG AKWREFSANN PFKGSAAAVA AAAAAAAAAV AEQVSAAVSS ATPIAPSGPP
ALPPPPAADI QPPPIRRAKT KEGKGPGHKR RSKSPRVPDG RKKLRGKKMA PLKIKLGLLG
GKRKKGGSYV FQSDEGPEPE AEESDLDSGS VHSASGRPDG PVRTKKLKRG RPGRKKKKVL
GCPAVAGEEE VDGYETDHQD YCEVCQQGGE IILCDTCPRA YHLVCLDPEL DRAPEGKWSC
PHCEKEGVQW EAKEEEEEYE EEGEEEGEKE EEDDHMEYCR VCKDGGELLC CDACISSYHI
HCLNPPLPDI PNGEWLCPRC TCPVLKGRVQ KILHWRWGEP PVAVPAPQQA DGNPDVPPPR
PLQGRSEREF FVKWVGLSYW HCSWAKELQL EIFHLVMYRN YQRKNDMDEP PPLDYGSGED
DGKSDKRKVK DPHYAEMEEK YYRFGIKPEW MTVHRIINHS VDKKGNYHYL VKWRDLPYDQ
STWEEDEMNI PEYEEHKQSY WRHRELIMGE DPAQPRKYKK KKKELQGDGP PSSPTNDPTV
KYETQPRFIT ATGGTLHMYQ LEGLNWLRFS WAQGTDTILA DEMGLGKTIQ TIVFLYSLYK
EGHTKGPFLV SAPLSTIINW EREFQMWAPK FYVVTYTGDK DSRAIIRENE FSFEDNAIKG
GKKAFKMKRE AQVKFHVLLT SYELITIDQA ALGSIRWACL VVDEAHRLKN NQSKFFRVLN
GYKIDHKLLL TGTPLQNNLE ELFHLLNFLT PERFNNLEGF LEEFADISKE DQIKKLHDLL
GPHMLRRLKA DVFKNMPAKT ELIVRVELSP MQKKYYKYIL TRNFEALNSR GGGNQVSLLN
IMMDLKKCCN HPYLFPVAAM ESPKLPSGAY EGGALIKSSG KLMLLQKMLR KLKEQGHRVL
IFSQMTKMLD LLEDFLDYEG YKYERIDGGI TGALRQEAID RFNAPGAQQF CFLLSTRAGG
LGINLATADT VIIFDSDWNP HNDIQAFSRA HRIGQANKVM IYRFVTRASV EERITQVAKR
KMMLTHLVVR PGLGSKAGSM SKQELDDILK FGTEELFKDE NEGENKEEDS SVIHYDNEAI
ARLLDRNQDA TEDTDVQNMN EYLSSFKVAQ YVVREEDKIE EIEREIIKQE ENVDPDYWEK
LLRHHYEQQQ EDLARNLGKG KRVRKQVNYN DAAQEDQDNQ SEYSVGSEEE DEDFDERPEG
RRQSKRQLRN EKDKPLPPLL ARVGGNIEVL GFNTRQRKAF LNAVMRWGMP PQDAFTTQWL
VRDLRGKTEK EFKAYVSLFM RHLCEPGADG SETFADGVPR EGLSRQQVLT RIGVMSLVKK
KVQEFEHING RWSMPELMPD PSADSKRSSR ASSPTKTSPT TPEASATNSP CTSKPATPAP
SEKGEGIRTP LEKEEAENQE EKPEKNSRIG EKMETEADAP SPAPSLGERL EPRKIPLEDE
VPGVPGEMEP EPGYRGDREK SATESTPGER GEEKPLDGQE HRERPEGETG DLGKREDVKG
DRELRPGPRD EPRSNGRREE KTEKPRFMFN IADGGFTELH TLWQNEERAA ISSGKLNEIW
HRRHDYWLLA GIVLHGYARW QDIQNDAQFA IINEPFKTEA NKGNFLEMKN KFLARRFKLL
EQALVIEEQL RRAAYLNLSQ EPAHPAMALH ARFAEAECLA ESHQHLSKES LAGNKPANAV
LHKVLNQLEE LLSDMKADVT RLPATLSRIP PIAARLQMSE RSILSRLASK GTEPHPTPAY
PPGPYATPPG YGAAFSAAPV GALAAAGANY SQMPAGSFIT AATNGPPVLV KKEKEMVGAL
VSDGLDRKEP RAGEVICIDD

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
148	201	Domain	CHD, N-terminal	IPR012958	PF08073
157	221	Homologous_superfamily	High mobility group box domain superfamily	IPR036910	G3DSA:1.10.30.10
159	198	Homologous_superfamily	High mobility group box domain superfamily	IPR036910	SSF47095
369	425	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
370	429	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
379	426	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
381	424	Domain	Zinc finger, PHD-type	IPR001965	SM00249
381	425	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
382	423	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
431	509	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
456	503	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
458	502	Domain	Zinc finger, PHD-finger	IPR019787	PF00628
458	501	Domain	Zinc finger, PHD-type	IPR001965	SM00249
471	591	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
506	585	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
536	593	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
611	684	Homologous_superfamily	Chromo-like domain superfamily	IPR016197	SSF54160
629	678	Domain	Chromo/chromo shadow domain	IPR000953	SM00298
631	667	Domain	Chromo/chromo shadow domain	IPR000953	PS50013
632	682	Domain	Chromo domain	IPR023780	PF00385
649	668	Conserved_site	Chromo domain, conserved site	IPR023779	PS00598
731	976	Homologous_superfamily	SNF2-like, N-terminal domain superfamily	IPR038718	G3DSA:3.40.50.10810
732	944	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	SM00487
735	967	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
748	932	Domain	Helicase superfamily 1/2, ATP-binding domain	IPR014001	PS51192
755	1034	Domain	SNF2, N-terminal	IPR000330	PF00176
878	887	Conserved_site	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	IPR002464	PS00690
969	1244	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
977	1205	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
1062	1174	Domain	Helicase, C-terminal	IPR001650	PF00271
1064	1229	Domain	Helicase, C-terminal	IPR001650	PS51194
1090	1174	Domain	Helicase, C-terminal	IPR001650	SM00490
1293	1357	Domain	Domain of unknown function DUF1087	IPR009463	SM01147
1298	1356	Domain	Domain of unknown function DUF1087	IPR009463	PF06465
1363	1519	Domain	CHD subfamily II, SANT-like domain	IPR009462	SM01146
1379	1516	Domain	CHD subfamily II, SANT-like domain	IPR009462	PF06461
1737	1882	Domain	CHD, C-terminal 2	IPR012957	PF08074

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000117
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:27068747
GO:0006355	regulation of DNA-templated transcription	Biological Process	NAS	PMID:9688266
GO:0007051	spindle organization	Biological Process	IDA	PMID:17626165
GO:0007098	centrosome cycle	Biological Process	IDA	PMID:17626165
GO:0042659	regulation of cell fate specification	Biological Process	NAS	PMID:22560079
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	NAS	PMID:22560079
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	NAS	PMID:19927129
GO:2000736	regulation of stem cell differentiation	Biological Process	NAS	PMID:22560079
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0000785	chromatin	Cellular Component	IBA	GO_REF:0000033
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:0034451	centriolar satellite	Cellular Component	IDA	GO_REF:0000052
GO:0016581	NuRD complex	Cellular Component	IBA	GO_REF:0000033
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004386	helicase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000976	transcription cis-regulatory region binding	Molecular Function	IDA	PMID:27068747
GO:0003682	chromatin binding	Molecular Function	IBA	GO_REF:0000033
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:12505151
GO:0016887	ATP hydrolysis activity	Molecular Function	IBA	GO_REF:0000033
GO:0042393	histone binding	Molecular Function	IBA	GO_REF:0000033
GO:0140658	ATP-dependent chromatin remodeler activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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