RB40B

Details:

UniProt Entry: Q12829
Gene: RAB40B
Class: Other E3 Components
Family: Receptor
Protein length: 278
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q12829
MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG
RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP
KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM
DRLWRPSKVL SLQDLCCRAV VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS
YSLTTSSTHK RSSLRKVKLV RPPQSPPKNC TRNSCKIS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	236	Family	Small GTPase	IPR001806	PS51421
7	186	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	G3DSA:3.40.50.300
11	181	Homologous_superfamily	P-loop containing nucleoside triphosphate hydrolase	IPR027417	SSF52540
16	163	Domain	Small GTP-binding protein domain	IPR005225	TIGR00231
16	174	Family	Small GTPase	IPR001806	PF00071
17	177	Family	Small GTPase	IPR001806	SM00174
175	228	Domain	SOCS box domain	IPR001496	PS50225
183	226	Domain	SOCS box domain	IPR001496	SM00253
189	227	Homologous_superfamily	SOCS box-like domain superfamily	IPR036036	SSF158235
189	223	Domain	SOCS box domain	IPR001496	PF07525
189	225	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035556	intracellular signal transduction	Biological Process	IEA	GO_REF:0000002
GO:0006887	exocytosis	Biological Process	IBA	GO_REF:0000033
GO:0030335	positive regulation of cell migration	Biological Process	IMP	PMID:33999101
GO:0032232	negative regulation of actin filament bundle assembly	Biological Process	IMP	PMID:33999101
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:33999101
GO:1902743	regulation of lamellipodium organization	Biological Process	IMP	PMID:33999101
GO:1990748	cellular detoxification	Biological Process	IMP	PMID:22042847
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IBA	GO_REF:0000033
GO:0008021	synaptic vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0001726	ruffle	Cellular Component	IEA	GO_REF:0000044
GO:0005635	nuclear envelope	Cellular Component	IDA	PMID:22042847
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0030027	lamellipodium	Cellular Component	IDA	PMID:33999101
GO:0031258	lamellipodium membrane	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:22042847
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0003924	GTPase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005525	GTP binding	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:27789576
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IMP	PMID:33999101

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