EP300

>Q09472
MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD
INQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQVMASQAQQ SSPGLGLINS
MVKSPMTQAG LTSPNMGMGT SGPNQGPTQS TGMMNSPVNQ PAMGMNTGMN AGMNPGMLAA
GNGQGIMPNQ VMNGSIGAGR GRQNMQYPNP GMGSAGNLLT EPLQQGSPQM GGQTGLRGPQ
PLKMGMMNNP NPYGSPYTQN PGQQIGASGL GLQIQTKTVL SNNLSPFAMD KKAVPGGGMP
NMGQQPAPQV QQPGLVTPVA QGMGSGAHTA DPEKRKLIQQ QLVLLLHAHK CQRREQANGE
VRQCNLPHCR TMKNVLNHMT HCQSGKSCQV AHCASSRQII SHWKNCTRHD CPVCLPLKNA
GDKRNQQPIL TGAPVGLGNP SSLGVGQQSA PNLSTVSQID PSSIERAYAA LGLPYQVNQM
PTQPQVQAKN QQNQQPGQSP QGMRPMSNMS ASPMGVNGGV GVQTPSLLSD SMLHSAINSQ
NPMMSENASV PSLGPMPTAA QPSTTGIRKQ WHEDITQDLR NHLVHKLVQA IFPTPDPAAL
KDRRMENLVA YARKVEGDMY ESANNRAEYY HLLAEKIYKI QKELEEKRRT RLQKQNMLPN
AAGMVPVSMN PGPNMGQPQP GMTSNGPLPD PSMIRGSVPN QMMPRITPQS GLNQFGQMSM
AQPPIVPRQT PPLQHHGQLA QPGALNPPMG YGPRMQQPSN QGQFLPQTQF PSQGMNVTNI
PLAPSSGQAP VSQAQMSSSS CPVNSPIMPP GSQGSHIHCP QLPQPALHQN SPSPVPSRTP
TPHHTPPSIG AQQPPATTIP APVPTPPAMP PGPQSQALHP PPRQTPTPPT TQLPQQVQPS
LPAAPSADQP QQQPRSQQST AASVPTPTAP LLPPQPATPL SQPAVSIEGQ VSNPPSTSST
EVNSQAIAEK QPSQEVKMEA KMEVDQPEPA DTQPEDISES KVEDCKMEST ETEERSTELK
TEIKEEEDQP STSATQSSPA PGQSKKKIFK PEELRQALMP TLEALYRQDP ESLPFRQPVD
PQLLGIPDYF DIVKSPMDLS TIKRKLDTGQ YQEPWQYVDD IWLMFNNAWL YNRKTSRVYK
YCSKLSEVFE QEIDPVMQSL GYCCGRKLEF SPQTLCCYGK QLCTIPRDAT YYSYQNRYHF
CEKCFNEIQG ESVSLGDDPS QPQTTINKEQ FSKRKNDTLD PELFVECTEC GRKMHQICVL
HHEIIWPAGF VCDGCLKKSA RTRKENKFSA KRLPSTRLGT FLENRVNDFL RRQNHPESGE
VTVRVVHASD KTVEVKPGMK ARFVDSGEMA ESFPYRTKAL FAFEEIDGVD LCFFGMHVQE
YGSDCPPPNQ RRVYISYLDS VHFFRPKCLR TAVYHEILIG YLEYVKKLGY TTGHIWACPP
SEGDDYIFHC HPPDQKIPKP KRLQEWYKKM LDKAVSERIV HDYKDIFKQA TEDRLTSAKE
LPYFEGDFWP NVLEESIKEL EQEEEERKRE ENTSNESTDV TKGDSKNAKK KNNKKTSKNK
SSLSRGNKKK PGMPNVSNDL SQKLYATMEK HKEVFFVIRL IAGPAANSLP PIVDPDPLIP
CDLMDGRDAF LTLARDKHLE FSSLRRAQWS TMCMLVELHT QSQDRFVYTC NECKHHVETR
WHCTVCEDYD LCITCYNTKN HDHKMEKLGL GLDDESNNQQ AAATQSPGDS RRLSIQRCIQ
SLVHACQCRN ANCSLPSCQK MKRVVQHTKG CKRKTNGGCP ICKQLIALCC YHAKHCQENK
CPVPFCLNIK QKLRQQQLQH RLQQAQMLRR RMASMQRTGV VGQQQGLPSP TPATPTTPTG
QQPTTPQTPQ PTSQPQPTPP NSMPPYLPRT QAAGPVSQGK AAGQVTPPTP PQTAQPPLPG
PPPAAVEMAM QIQRAAETQR QMAHVQIFQR PIQHQMPPMT PMAPMGMNPP PMTRGPSGHL
EPGMGPTGMQ QQPPWSQGGL PQPQQLQSGM PRPAMMSVAQ HGQPLNMAPQ PGLGQVGISP
LKPGTVSQQA LQNLLRTLRS PSSPLQQQQV LSILHANPQL LAAFIKQRAA KYANSNPQPI
PGQPGMPQGQ PGLQPPTMPG QQGVHSNPAM QNMNPMQAGV QRAGLPQQQP QQQLQPPMGG
MSPQAQQMNM NHNTMPSQFR DILRRQQMMQ QQQQQGAGPG IGPGMANHNQ FQQPQGVGYP
PQQQQRMQHH MQQMQQGNMG QIGQLPQALG AEAGASLQAY QQRLLQQQMG SPVQPNPMSP
QQHMLPNQAQ SPHLQGQQIP NSLSNQVRSP QPVPSPRPQS QPPHSSPSPR MQPQPSPHHV
SPQTSSPHPG LVAAQANPME QGHFASPDQN SMLSQLASNP GMANLHGASA TDLGLSTDNS
DLNSNLSQST LDIH

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
10	685	Family	Histone acetyltransferase Rtt109/CBP	IPR013178	PTHR13808
323	423	Homologous_superfamily	TAZ domain superfamily	IPR035898	G3DSA:1.20.1020.10
326	421	Homologous_superfamily	TAZ domain superfamily	IPR035898	SSF57933
331	417	Domain	Zinc finger, TAZ-type	IPR000197	PS50134
332	417	Domain	Zinc finger, TAZ-type	IPR000197	SM00551
338	414	Domain	Zinc finger, TAZ-type	IPR000197	PF02135
566	645	Domain	Coactivator CBP, KIX domain	IPR003101	PS50952
566	652	Homologous_superfamily	Coactivator CBP, KIX domain superfamily	IPR036529	G3DSA:1.10.246.20
567	651	Homologous_superfamily	Coactivator CBP, KIX domain superfamily	IPR036529	SSF47040
567	646	Domain	Coactivator CBP, KIX domain	IPR003101	PF02172
1035	1161	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	SSF47370
1044	1161	Homologous_superfamily	Bromodomain-like superfamily	IPR036427	G3DSA:1.20.920.10
1048	1158	Domain	Bromodomain	IPR001487	SM00297
1067	1139	Domain	Bromodomain	IPR001487	PS50014
1068	1143	Domain	Bromodomain	IPR001487	PF00439
1070	1083	Domain	Bromodomain	IPR001487	PR00503
1072	1131	Conserved_site	Bromodomain, conserved site	IPR018359	PS00633
1086	1102	Domain	Bromodomain	IPR001487	PR00503
1102	1120	Domain	Bromodomain	IPR001487	PR00503
1120	1139	Domain	Bromodomain	IPR001487	PR00503
1156	1195	Domain	CREB-binding protein/p300, atypical RING domain	IPR010303	PF06001
1170	1242	Domain	CREB-binding protein/p300, atypical RING domain	IPR010303	cd15802
1170	1237	Homologous_superfamily	CBP/p300, atypical RING domain superfamily	IPR038547	G3DSA:2.10.110.40
1238	1282	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1287	1663	Domain	CBP/p300-type histone acetyltransferase domain	IPR031162	PS51727
1306	1609	Family	Histone acetyltransferase Rtt109/CBP	IPR013178	PF08214
1306	1611	Family	Histone acetyltransferase Rtt109/CBP	IPR013178	SM01250
1662	1714	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
1664	1705	Domain	Zinc finger, ZZ-type	IPR000433	SM00291
1665	1713	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
1665	1705	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
1670	1695	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
1723	1836	Homologous_superfamily	TAZ domain superfamily	IPR035898	G3DSA:1.20.1020.10
1727	1812	Homologous_superfamily	TAZ domain superfamily	IPR035898	SSF57933
1728	1809	Domain	Zinc finger, TAZ-type	IPR000197	PS50134
1729	1807	Domain	Zinc finger, TAZ-type	IPR000197	SM00551
1735	1806	Domain	Zinc finger, TAZ-type	IPR000197	PF02135
1992	2098	Domain	Nuclear receptor coactivator, CREB-bp-like, interlocking	IPR014744	PF09030
2043	2098	Homologous_superfamily	Nuclear receptor coactivator, interlocking	IPR009110	SSF69125
2044	2093	Homologous_superfamily	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	IPR037073	G3DSA:1.10.1630.10

GO term	Name	Ontology	Evidence	Reference
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000002
GO:0001666	response to hypoxia	Biological Process	IEA	GO_REF:0000117
GO:0002223	stimulatory C-type lectin receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000117
GO:0031669	cellular response to nutrient levels	Biological Process	IEA	GO_REF:0000117
GO:0034644	cellular response to UV	Biological Process	IEA	GO_REF:0000117
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000117
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:1900034	regulation of cellular response to heat	Biological Process	IEA	GO_REF:0000117
GO:1900182	positive regulation of protein localization to nucleus	Biological Process	IEA	GO_REF:0000117
GO:0006366	transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0000045	autophagosome assembly	Biological Process	IDA	PMID:28890335
GO:0001756	somitogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006094	gluconeogenesis	Biological Process	IDA	PMID:30193097
GO:0006096	glycolytic process	Biological Process	IDA	PMID:20847263
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0007259	cell surface receptor signaling pathway via JAK-STAT	Biological Process	IDA	PMID:8272873
GO:0007507	heart development	Biological Process	IEA	GO_REF:0000107
GO:0007519	skeletal muscle tissue development	Biological Process	IEA	GO_REF:0000107
GO:0008610	lipid biosynthetic process	Biological Process	IDA	PMID:21084751
GO:0009887	animal organ morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0010507	negative regulation of autophagy	Biological Process	IDA	PMID:32561715
GO:0010628	positive regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0030183	B cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0030220	platelet formation	Biological Process	IEA	GO_REF:0000107
GO:0030324	lung development	Biological Process	IEA	GO_REF:0000107
GO:0035855	megakaryocyte development	Biological Process	IEA	GO_REF:0000107
GO:0035987	endodermal cell differentiation	Biological Process	IDA	PMID:32895492
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:12087098
GO:0038203	TORC2 signaling	Biological Process	IDA	PMID:21343617
GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:28147277
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:9094314
GO:0071168	protein localization to chromatin	Biological Process	IDA	PMID:28262505
GO:0072350	tricarboxylic acid metabolic process	Biological Process	IDA	PMID:30193097
GO:0072540	T-helper 17 cell lineage commitment	Biological Process	TAS	PMID:27893700
GO:2000330	positive regulation of T-helper 17 cell lineage commitment	Biological Process	IDA	PMID:28262505
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:10733570
GO:0001966	thigmotaxis	Biological Process	IEA	GO_REF:0000107
GO:0002209	behavioral defense response	Biological Process	IEA	GO_REF:0000107
GO:0006110	regulation of glycolytic process	Biological Process	IDA	PMID:29775581
GO:0006473	protein acetylation	Biological Process	IDA	PMID:21030595
GO:0006475	internal protein amino acid acetylation	Biological Process	IDA	PMID:18722353
GO:0006915	apoptotic process	Biological Process	IMP	PMID:9194565
GO:0007399	nervous system development	Biological Process	TAS	PMID:10205054
GO:0007611	learning or memory	Biological Process	IEA	GO_REF:0000107
GO:0007623	circadian rhythm	Biological Process	ISS	GO_REF:0000024
GO:0010506	regulation of autophagy	Biological Process	TAS	PMID:24852146
GO:0010821	regulation of mitochondrion organization	Biological Process	ISS	GO_REF:0000024
GO:0010976	positive regulation of neuron projection development	Biological Process	IDA	PMID:27256286
GO:0018076	N-terminal peptidyl-lysine acetylation	Biological Process	IDA	PMID:12435739
GO:0018393	internal peptidyl-lysine acetylation	Biological Process	IDA	PMID:17403783
GO:0031333	negative regulation of protein-containing complex assembly	Biological Process	IDA	PMID:23962722
GO:0032460	negative regulation of protein oligomerization	Biological Process	IMP	PMID:23962722
GO:0035264	multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0036268	swimming	Biological Process	IEA	GO_REF:0000107
GO:0042307	positive regulation of protein import into nucleus	Biological Process	IDA	PMID:24120661
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Biological Process	IDA	PMID:17403783
GO:0043627	response to estrogen	Biological Process	IDA	PMID:11581164
GO:0043923	positive regulation by host of viral transcription	Biological Process	IDA	PMID:16687403
GO:0045444	fat cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0045721	negative regulation of gluconeogenesis	Biological Process	IDA	PMID:30193097
GO:0045815	transcription initiation-coupled chromatin remodeling	Biological Process	IDA	PMID:25818647
GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Biological Process	IDA	PMID:16257975
GO:0050821	protein stabilization	Biological Process	ISS	GO_REF:0000024
GO:0051091	positive regulation of DNA-binding transcription factor activity	Biological Process	IDA	PMID:25818647
GO:0060070	canonical Wnt signaling pathway	Biological Process	IDA	PMID:12408825
GO:0060325	face morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0060765	regulation of androgen receptor signaling pathway	Biological Process	IDA	PMID:18487222
GO:0061921	peptidyl-lysine propionylation	Biological Process	IDA	PMID:17267393
GO:0071233	cellular response to L-leucine	Biological Process	IDA	PMID:30197302
GO:0090043	regulation of tubulin deacetylation	Biological Process	IDA	PMID:18722353
GO:0140066	peptidyl-lysine crotonylation	Biological Process	IDA	PMID:25818647
GO:0140067	peptidyl-lysine butyrylation	Biological Process	IDA	PMID:17267393
GO:1901796	regulation of signal transduction by p53 class mediator	Biological Process	TAS	Reactome:R-HSA-6804758
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:30197302
GO:1904515	positive regulation of TORC2 signaling	Biological Process	IDA	PMID:22084251
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0000123	histone acetyltransferase complex	Cellular Component	IEA	GO_REF:0000002
GO:0000785	chromatin	Cellular Component	IDA	PMID:21084751
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005667	transcription regulator complex	Cellular Component	IBA	GO_REF:0000033
GO:0032991	protein-containing complex	Cellular Component	IEA	GO_REF:0000107
GO:0032993	protein-DNA complex	Cellular Component	ISS	PMID:10362258
GO:0003712	transcription coregulator activity	Molecular Function	IEA	GO_REF:0000002
GO:0004402	histone acetyltransferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0001223	transcription coactivator binding	Molecular Function	IEA	GO_REF:0000117
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000117
GO:0003684	damaged DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0003713	transcription coactivator activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016746	acyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0043993	histone H3K18 acetyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0044017	histone H3K27 acetyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Molecular Function	IEA	GO_REF:0000117
GO:0120300	peptide lactyltransferase (CoA-dependent) activity	Molecular Function	IEA	GO_REF:0000117
GO:0001221	transcription coregulator binding	Molecular Function	IPI	PMID:8684459
GO:0002039	p53 binding	Molecular Function	IEA	GO_REF:0000107
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0004468	L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	Molecular Function	IDA	PMID:20019387
GO:0005515	protein binding	Molecular Function	IPI	PMID:10049825
GO:0008013	beta-catenin binding	Molecular Function	IPI	PMID:12408825
GO:0010484	histone H3 acetyltransferase activity	Molecular Function	IDA	PMID:12609999
GO:0010485	histone H4 acetyltransferase activity	Molecular Function	IDA	PMID:10821277
GO:0016407	acetyltransferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0016922	nuclear receptor binding	Molecular Function	IPI	PMID:9862959
GO:0031490	chromatin DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0044013	histone H2B acetyltransferase activity	Molecular Function	IDA	PMID:10821277
GO:0048156	tau protein binding	Molecular Function	NAS	PMID:28386764
GO:0050681	nuclear androgen receptor binding	Molecular Function	IPI	PMID:18487222
GO:0051059	NF-kappaB binding	Molecular Function	IPI	PMID:23811396
GO:0061733	protein-lysine-acetyltransferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0061920	protein propionyltransferase activity	Molecular Function	IEA	GO_REF:0000116
GO:0097157	pre-mRNA intronic binding	Molecular Function	IEA	GO_REF:0000107
GO:0097677	STAT family protein binding	Molecular Function	IPI	PMID:26479788
GO:0106226	peptide 2-hydroxyisobutyryltransferase activity	Molecular Function	IEA	GO_REF:0000116
GO:0120301	histone lactyltransferase (CoA-dependent) activity	Molecular Function	IDA	PMID:31645732
GO:0140033	acetylation-dependent protein binding	Molecular Function	IDA	PMID:18782771
GO:0140064	peptide crotonyltransferase activity	Molecular Function	IEA	GO_REF:0000116
GO:0140065	peptide butyryltransferase activity	Molecular Function	IEA	GO_REF:0000116
GO:0140068	histone crotonyltransferase activity	Molecular Function	IDA	PMID:25818647
GO:0140069	histone butyryltransferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IEA	GO_REF:0000107
GO:0140566	histone reader activity	Molecular Function	IDA	PMID:21131905
GO:0140908	histone H3K122 acetyltransferase activity	Molecular Function	IDA	PMID:23415232

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL445599	ChEMBL	6.3	—	—	C=C(C)[C@H](CC=C(C)C)C[C@]12C[C@H](CC=C(C)C)C(C)(C)[C@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O
E3 Binder	CHEMBL3899464	ChEMBL	6.52	—	—	CC(=O)N1CCc2[nH]nc(Nc3ccc(C)cc3)c2C1
E3 Binder	CHEMBL3947092	ChEMBL	6.04	—	—	CC(=O)N1CCc2[nH]nc(Nc3ccc(F)cc3)c2C1
E3 Binder	CHEMBL3898753	ChEMBL	7.0	—	—	CC(=O)N1CCc2[nH]nc(Nc3cccc(C(F)(F)F)c3)c2C1
E3 Binder	CHEMBL3970636	ChEMBL	6.47	—	—	CC(=O)N1CCc2[nH]nc(Nc3cccc(C)c3)c2C1
E3 Binder	CHEMBL3908519	ChEMBL	6.37	—	—	CC(=O)N1CCc2[nH]nc(Nc3cccc(F)c3)c2C1
E3 Binder	CHEMBL3891644	ChEMBL	6.8	—	—	CC(=O)N1CCc2[nH]nc(Nc3cccc(OC(F)F)c3)c2C1
E3 Binder	CHEMBL3959584	ChEMBL	6.21	—	—	CC(=O)N1CCc2[nH]nc(Nc3ccccc3)c2C1
E3 Binder	CHEMBL4204065	ChEMBL	6.55	—	—	CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C#N)ncc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4209361	ChEMBL	6.66	—	—	CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C(F)F)ncc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4203082	ChEMBL	7.5	—	—	CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)ncc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4204490	ChEMBL	7.12	—	—	CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C#N)ncc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4207965	ChEMBL	6.96	—	—	CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C(F)F)ncc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4076748	ChEMBL	8.89	9UD	—	CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1
E3 Binder	CHEMBL3985118	ChEMBL	7.4	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2C)C1
E3 Binder	CHEMBL3915331	ChEMBL	7.4	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2C2COC2)C1
E3 Binder	CHEMBL3917504	ChEMBL	7.7	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2CC2CC2)C1
E3 Binder	CHEMBL3896323	ChEMBL	7.7	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2[C@@H]2CCOC2)C1
E3 Binder	CHEMBL3924330	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3)nn2[C@H]2CCOC2)C1
E3 Binder	CHEMBL3968533	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@@H]2CCOC2)C1
E3 Binder	CHEMBL3911524	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4cc[nH]n4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3902514	ChEMBL	8.0	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4ccccc4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3973515	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4ccccn4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3893541	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4cccnc4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3962542	ChEMBL	7.7	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4ccncc4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3938408	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4ccnn4C)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3892467	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4cn[nH]c4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3981511	ChEMBL	7.7	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4cnn(C)c4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3920459	ChEMBL	7.52	—	—	CC(=O)N1CCc2c(c(Nc3cccc(-c4cnoc4)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3943463	ChEMBL	6.44	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C(=O)N(C)C)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3889679	ChEMBL	7.52	6XG	—	CC(=O)N1CCc2c(c(Nc3cccc(C(=O)NC(C)C)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3972721	ChEMBL	6.7	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2C)C1
E3 Binder	CHEMBL3900573	ChEMBL	6.82	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2C2CC2)C1
E3 Binder	CHEMBL3962757	ChEMBL	7.22	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CC2CC2)C1
E3 Binder	CHEMBL3928531	ChEMBL	6.66	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCC#N)C1
E3 Binder	CHEMBL3909879	ChEMBL	6.75	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCC2CC2)C1
E3 Binder	CHEMBL3891576	ChEMBL	6.51	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2CCO)C1
E3 Binder	CHEMBL3897524	ChEMBL	6.85	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccccc2)C1
E3 Binder	CHEMBL3936675	ChEMBL	7.05	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccccn2)C1
E3 Binder	CHEMBL3986361	ChEMBL	6.85	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2cccnc2)C1
E3 Binder	CHEMBL3916599	ChEMBL	6.7	—	—	CC(=O)N1CCc2c(c(Nc3cccc(C)c3)nn2Cc2ccncc2)C1
E3 Binder	CHEMBL505121	ChEMBL	8.49	—	—	CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(N)=O
E3 Binder	CHEMBL4789343	ChEMBL	6.3	—	—	CC(=O)N[C@@H](CCCCNC(=O)CSCCNC(=O)[C@H](O)CCOP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3cncnc32)[C@H](O)[C@@H]1OP(=O)(O)O)C(N)=O.O=C(O)C(F)(F)F
E3 Binder	CHEMBL4167383	ChEMBL	6.11	—	—	CC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)C(C)C2CC2)C1=O
E3 Binder	CHEMBL4159164	ChEMBL	6.01	—	—	CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2ccccc21
E3 Binder	CHEMBL3775655	ChEMBL	7.16	—	—	CC(C)(C)OC(=O)NCCCCCNC(=O)CSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O
E3 Binder	CHEMBL4474132	ChEMBL	6.21	—	—	CC(C)(C)c1ccc(-c2cc(CNCC3CCNCC3)sc2-c2ccc(C(C)(C)C)cc2)cc1
E3 Binder	CHEMBL4466328	ChEMBL	6.28	—	—	CC(C)C[C@@H]1NCCN([C@@H](CC(C)C)C(=O)N2CCN([C@@H](CCC(N)=O)C(N)=O)C(=O)[C@@H]2C)C1=O
E3 Binder	CHEMBL4524475	ChEMBL	6.16	—	—	CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)N1C/C=C/CCN[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
E3 Binder	CHEMBL4435255	ChEMBL	6.16	—	—	CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)N1CC/C=C\CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
E3 Binder	CHEMBL4526489	ChEMBL	6.17	—	—	CC1=NN(c2ccc(-c3nn[nH]n3)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL3734823	ChEMBL	8.01	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C/c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL4436898	ChEMBL	6.54	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2C(F)(F)F)o1
E3 Binder	CHEMBL1797936	ChEMBL	6.64	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL4449504	ChEMBL	6.64	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])s1
E3 Binder	CHEMBL4474848	ChEMBL	6.24	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cccc3c2C(=O)CC3)o1
E3 Binder	CHEMBL4452893	ChEMBL	6.25	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2ccccc2[N+](=O)[O-])o1
E3 Binder	CHEMBL4449804	ChEMBL	6.07	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1cnc(-c2cc(C)c(C)cc2[N+](=O)[O-])s1
E3 Binder	CHEMBL4208500	ChEMBL	6.4	—	—	CC1=NN(c2ccc(C(=O)O)cc2)C(=O)C1=Cc1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL4448489	ChEMBL	6.33	—	—	CC1=NN(c2ccc(P(=O)(O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL3927642	ChEMBL	6.87	6F9	—	CCC(=O)N1CCOc2c(cc(-c3cc(OC)cc(OC)c3)cc2C(=O)N[C@H]2CCCN(C)C2)C1
E3 Binder	CHEMBL3774655	ChEMBL	6.82	—	—	CCC(=O)N1CCOc2c(cc(-c3ccc(OC)c(OC)c3)cc2OC[C@H]2CCCN(C)C2)C1
E3 Binder	CHEMBL4515273	ChEMBL	6.72	—	—	CCC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C\c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1
E3 Binder	CHEMBL4579084	ChEMBL	6.12	—	—	CCCCC[C@H](O)C/C=C1/C(=O)C=C[C@@H]1C/C=C/CCCC(=O)O
E3 Binder	CHEMBL3934488	ChEMBL	7.52	—	—	CCCNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL4474031	ChEMBL	8.4	—	—	CCC[C@@H]1CCc2ccccc2CN1C(=O)CN1C(=O)O[C@@]2(CCc3cc(NC(=O)NC)ccc32)C1=O
E3 Binder	CHEMBL3980755	ChEMBL	7.16	—	—	CCCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2
E3 Binder	CHEMBL3416552	ChEMBL	6.58	—	—	CCN(CC)c1ccc2c(C)c(-c3ccc(N4C(=O)C=CC4=O)cc3)c(=O)oc2c1
E3 Binder	CHEMBL4794518	ChEMBL	8.06	—	—	CCNC(=O)c1ccc2c(C(=O)[C@H](NC[C@@H](C)c3ccc(C#N)cc3)c3ccccc3)c[nH]c2c1
E3 Binder	CHEMBL3906525	ChEMBL	7.4	—	—	CCNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL4648912	ChEMBL	7.43	—	—	CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1
E3 Binder	CHEMBL5074479	ChEMBL	6.64	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)O
E3 Binder	CHEMBL5080878	ChEMBL	7.44	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
E3 Binder	CHEMBL4593074	ChEMBL	7.8	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)O)C(C)C
E3 Binder	CHEMBL5074760	ChEMBL	7.67	—	—	CC[C@H](C)[C@H](NC(=O)[C@@H]1CNC(=O)[C@@H](N)CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)C(C)C
E3 Binder	CHEMBL5092869	ChEMBL	7.65	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C
E3 Binder	CHEMBL5081656	ChEMBL	7.53	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C
E3 Binder	CHEMBL5090131	ChEMBL	7.75	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O
E3 Binder	CHEMBL5087442	ChEMBL	7.43	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
E3 Binder	CHEMBL5084183	ChEMBL	7.47	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H]1CNC(=O)[C@@H](N)CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(N)=O
E3 Binder	CHEMBL5088177	ChEMBL	7.5	—	—	CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
E3 Binder	CHEMBL4741587	ChEMBL	6.33	99E	—	CCc1c(C(=O)NCc2c(O)ccc3cccc(O)c23)[nH]c(C)c1C(C)=O
E3 Binder	CHEMBL3935734	ChEMBL	6.6	—	—	CCc1ccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)cc1
E3 Binder	CHEMBL3963381	ChEMBL	6.72	—	—	CCc1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL3769507	ChEMBL	6.11	H1B	—	CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O
E3 Binder	CHEMBL3910675	ChEMBL	7.05	—	—	CCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2
E3 Binder	CHEMBL4436408	ChEMBL	6.57	67B	—	CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1
E3 Binder	CHEMBL4542925	ChEMBL	6.22	—	—	CN1C(=O)[C@@]2(Cc3ccc(CCc4ccc(C[C@@]56SS[C@@](CO)(C(=O)N5C)N(C)C6=O)cc4)cc3)NC(=O)[C@]1(CO)SS2
E3 Binder	CHEMBL4555191	ChEMBL	6.12	—	—	CN1C(=O)[C@@]2(Cc3ccc(C[C@]45SS[C@](CO)(C(=O)N4C)N(C)C5=O)cc3)SS[C@]1(CO)C(=O)N2C
E3 Binder	CHEMBL4468788	ChEMBL	6.22	—	—	CN1C(=O)[C@]2(Cc3ccc(CCc4ccc(C[C@@]56SS[C@@](CO)(C(=O)N5C)N(C)C6=O)cc4)cc3)SS[C@@]1(CO)C(=O)N2C
E3 Binder	CHEMBL499593	ChEMBL	6.27	—	—	CN1C(=O)[C@]2(Cc3cn([C@]45C[C@@]67SS[C@@](CO)(C(=O)N6[C@H]4Nc4ccccc45)N(C)C7=O)c4ccccc34)SS[C@@]1(CO)C(=O)N2C
E3 Binder	CHEMBL4217213	ChEMBL	8.18	—	—	CNC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)c(C(F)F)cc34)nn2C2CCOCC2)C1
E3 Binder	CHEMBL4097025	ChEMBL	8.92	9U4	—	CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1
E3 Binder	CHEMBL5083020	ChEMBL	8.77	—	—	CNC(=O)Nc1cc2c(cc1F)[C@@]1(CC2)OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4173894	ChEMBL	6.62	—	—	CNC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O
E3 Binder	CHEMBL5083262	ChEMBL	7.96	—	—	CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5077158	ChEMBL	8.66	—	—	CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4582713	ChEMBL	7.14	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4282264	ChEMBL	7.87	6TF	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O
E3 Binder	CHEMBL4174931	ChEMBL	7.22	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C(F)(F)F)C1=O
E3 Binder	CHEMBL4166626	ChEMBL	7.6	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O
E3 Binder	CHEMBL4170186	ChEMBL	7.5	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@H](C2CC2)C(F)(F)F)C1=O
E3 Binder	CHEMBL5082755	ChEMBL	9.25	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)c(F)cc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4464962	ChEMBL	8.62	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL5090239	ChEMBL	9.31	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4457144	ChEMBL	8.72	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL4452911	ChEMBL	8.52	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C)C1=O
E3 Binder	CHEMBL4475351	ChEMBL	9.02	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4593536	ChEMBL	8.37	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(C)C)C1=O
E3 Binder	CHEMBL4449592	ChEMBL	8.59	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL4524352	ChEMBL	8.6	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O
E3 Binder	CHEMBL4552724	ChEMBL	8.43	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4584269	ChEMBL	7.92	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3OC[C@H]2C)C1=O
E3 Binder	CHEMBL5085891	ChEMBL	8.0	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cccnc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5078021	ChEMBL	8.01	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccncc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5084035	ChEMBL	7.89	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cnccc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5078353	ChEMBL	8.07	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ncccc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5089370	ChEMBL	6.37	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sc(C)c(C)c3OC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL5094423	ChEMBL	8.4	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4163183	ChEMBL	6.77	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O
E3 Binder	CHEMBL4439084	ChEMBL	8.12	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL4449940	ChEMBL	8.38	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4754103	ChEMBL	8.0	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O
E3 Binder	CHEMBL4177251	ChEMBL	6.92	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O
E3 Binder	CHEMBL4513653	ChEMBL	8.0	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O
E3 Binder	CHEMBL4472048	ChEMBL	7.34	—	—	CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O
E3 Binder	CHEMBL5073432	ChEMBL	7.92	—	—	CNC(=O)Nc1ccc2c(c1)COC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL5081689	ChEMBL	8.07	—	—	CNC(=O)Nc1ccc2c(c1)OCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O
E3 Binder	CHEMBL4061254	ChEMBL	7.28	—	—	CNC(=O)c1c[nH]c2c(C(C)C)nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12
E3 Binder	CHEMBL4073812	ChEMBL	6.44	—	—	CNC(=O)c1c[nH]c2cnc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12
E3 Binder	CHEMBL4208820	ChEMBL	9.92	—	—	CNC(=O)c1ccc(-c2cc3cccc(-c4nn(C5CCOCC5)c5c4CN(C(C)=O)CC5)c3cn2)cn1
E3 Binder	CHEMBL5221030	ChEMBL	9.1	—	—	CNC(=O)c1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)cc1
E3 Binder	CHEMBL5219712	ChEMBL	8.0	—	—	CNC(=O)c1cccc(CNC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)c1
E3 Binder	CHEMBL3915504	ChEMBL	7.16	—	—	CNC(=O)c1cccc(Nc2nn(CC3CC3)c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL4176737	ChEMBL	6.0	—	—	COC(=O)Nc1ccc2c(c1)CCC21NC(=O)N(CC(=O)N(Cc2ccccc2)[C@@H](C)C2CC2)C1=O
E3 Binder	CHEMBL4752387	ChEMBL	6.24	—	—	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cccc(OC)c5c4CCN3C[C@H]2CC[C@H]1O
E3 Binder	CHEMBL3926801	ChEMBL	6.85	—	—	COC(=O)c1ccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)cc1
E3 Binder	CHEMBL3907779	ChEMBL	6.96	—	—	COC(=O)c1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL3919629	ChEMBL	6.64	—	—	COCCn1nc(Nc2cccc(C)c2)c2c1CCN(C(C)=O)C2
E3 Binder	CHEMBL4171228	ChEMBL	6.26	8FV	—	COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12
E3 Binder	CHEMBL4173488	ChEMBL	6.96	EO4	—	COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12
E3 Binder	CHEMBL4457203	ChEMBL	6.38	—	—	COc1cc2c(cc1OC)-c1cc3cc(OC)c(OC)cc3c[n+]1CCC2.CS(=O)(=O)[O-]
E3 Binder	CHEMBL4573224	ChEMBL	6.38	—	—	COc1cc2c(cc1OC)-c1cc3ccc(OC)c(OC)c3c[n+]1CCC2.CS(=O)(=O)[O-]
E3 Binder	CHEMBL4759868	ChEMBL	6.16	—	—	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3NC1CC2
E3 Binder	CHEMBL5187549	ChEMBL	6.72	—	—	COc1ccc(C2(C(=O)N(C)CC(=O)Nc3cccc4[nH]ncc34)CCCCC2)cc1
E3 Binder	CHEMBL5191305	ChEMBL	6.66	—	—	COc1ccc(C2(C(=O)N(C)[C@H](C)C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5220447	ChEMBL	9.6	—	—	COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1
E3 Binder	CHEMBL5178312	ChEMBL	6.75	6TI	—	COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5184238	ChEMBL	6.77	—	—	COc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCCC2)cc1
E3 Binder	CHEMBL5174606	ChEMBL	7.3	—	—	COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCCC2)cc1
E3 Binder	CHEMBL5177811	ChEMBL	6.85	—	—	COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCCCC2)cc1
E3 Binder	CHEMBL5209027	ChEMBL	6.21	—	—	COc1ccc(C2(C(=O)N3CCOCC(Cc4cccc5[nH]ncc45)C3)CCOCC2)cc1
E3 Binder	CHEMBL5193672	ChEMBL	6.82	6YI	—	COc1ccc(C2(C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5180471	ChEMBL	6.04	—	—	COc1ccc(C2(C(=O)N3C[C@@H](O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5193437	ChEMBL	7.25	—	—	COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5207535	ChEMBL	6.58	—	—	COc1ccc(C2(C(=O)N3C[C@H](O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1
E3 Binder	CHEMBL5207333	ChEMBL	6.95	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CC(C)(C)OC(C)(C)C2)cc1Cl
E3 Binder	CHEMBL5192241	ChEMBL	7.08	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCC(F)(F)CC2)cc1Cl
E3 Binder	CHEMBL5192591	ChEMBL	7.03	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCN(C(C)=O)CC2)cc1Cl
E3 Binder	CHEMBL5179411	ChEMBL	6.83	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C2CCN(S(C)(=O)=O)CC2)cc1Cl
E3 Binder	CHEMBL3622373	ChEMBL	7.68	2LO	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C[C@H](C)N2CCOCC2)cc1Cl
E3 Binder	CHEMBL5177457	ChEMBL	6.05	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](C(F)(F)F)CC2)cc1Cl
E3 Binder	CHEMBL5186832	ChEMBL	7.32	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](O)CC2)cc1Cl
E3 Binder	CHEMBL5193321	ChEMBL	7.01	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl
E3 Binder	CHEMBL5199445	ChEMBL	6.81	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2C[C@H](O)C2)cc1Cl
E3 Binder	CHEMBL4867046	ChEMBL	6.54	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1
E3 Binder	CHEMBL4853072	ChEMBL	6.67	—	—	COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1Cl
E3 Binder	CHEMBL5285272	ChEMBL	7.68	—	—	COc1ccc(CCc2nc3ccc(-c4c(C)noc4C)cc3n2C[C@H](C)N2CCOCC2)cc1Cl
E3 Binder	CHEMBL5189469	ChEMBL	7.09	—	—	COc1ccc(N2C(=O)C[C@@H]2c2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl
E3 Binder	CHEMBL5177205	ChEMBL	7.31	—	—	COc1ccc(N2C(=O)C[C@H]2c2nc3cc(-c4c(C)noc4C)ccc3n2[C@H]2CC[C@H](OC)CC2)cc1Cl
E3 Binder	CHEMBL1700017	ChEMBL	6.8	C3I	—	COc1ccc(NC(=O)CN(C)C(=O)C2(c3ccccc3)CCCC2)cc1
E3 Binder	CHEMBL5221088	ChEMBL	8.3	—	—	COc1ccc(NC(=O)[C@H]2CCCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1
E3 Binder	CHEMBL5220135	ChEMBL	7.3	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C(C)(C)c2ccc(Cl)cc2)cc1
E3 Binder	CHEMBL5218875	ChEMBL	8.0	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCC2)cc1
E3 Binder	CHEMBL5219851	ChEMBL	8.1	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1
E3 Binder	CHEMBL5221117	ChEMBL	7.7	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccc(Cl)cc3)CCCCC2)cc1
E3 Binder	CHEMBL5219575	ChEMBL	7.0	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)cc1
E3 Binder	CHEMBL5219466	ChEMBL	8.7	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3cccc(Cl)c3)CCCC2)nc1
E3 Binder	CHEMBL5218485	ChEMBL	7.1	—	—	COc1ccc(NC(=O)[C@H]2CCCN2C(=O)C2(c3ccccc3)CCCC2)cc1
E3 Binder	CHEMBL5218882	ChEMBL	7.4	—	—	COc1ccc(NC(=O)[C@H]2CCN2C(=O)C2(c3ccc(Cl)cc3)CCCC2)cc1
E3 Binder	CHEMBL4080730	ChEMBL	6.0	—	—	COc1ccc(S(=O)(=O)N(Cc2ccc(CN3CCOCC3)cc2)C2CCC2)cc1OC
E3 Binder	CHEMBL4574165	ChEMBL	6.05	—	—	COc1ccc(S(=O)(=O)N(Cc2ccc(CN3CCOCC3)cc2)c2ccccc2)cc1OC
E3 Binder	CHEMBL1823895	ChEMBL	6.46	—	—	COc1ccc(S(=O)(=O)N(Cc2ccc3c(c2)C=CC(C)(C)O3)c2ccccc2)cc1OC
E3 Binder	CHEMBL1940227	ChEMBL	6.55	—	—	COc1ccc(S(=O)(=O)N(Cc2ccc3c(n2)C=CC(C)(C)O3)C2CCC2)cc1OC
E3 Binder	CHEMBL5183932	ChEMBL	7.32	—	—	COc1ccc2c(Cc3nc4cc(-c5c(C)noc5C)ccc4n3[C@H]3CC[C@H](O)CC3)cc(=O)oc2c1
E3 Binder	CHEMBL5089448	ChEMBL	6.62	OSN	—	COc1ccc2c(c1)N(CCC/C=C/c1cccc3c1N[C@H](C)CC(=O)N3)CCC2
E3 Binder	CHEMBL4163872	ChEMBL	6.29	—	—	COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1)cn2C(C)=O
E3 Binder	CHEMBL4171749	ChEMBL	7.31	EJ3	—	COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1F)cn2C(C)=O
E3 Binder	CHEMBL3917847	ChEMBL	6.47	—	—	COc1cccc(Nc2n[nH]c3c2CN(C(C)=O)CC3)c1
E3 Binder	CHEMBL5076857	ChEMBL	6.5	—	—	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O
E3 Binder	CHEMBL5088540	ChEMBL	6.65	—	—	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O
E3 Binder	CHEMBL4168543	ChEMBL	6.29	—	—	C[C@@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3ccccc32)C1=O
E3 Binder	CHEMBL3814752	ChEMBL	7.29	69E	—	C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(-c3cnn(C)c3)nn4C)c2N1
E3 Binder	CHEMBL4207557	ChEMBL	6.33	58N	—	C[C@@H]1CC(=O)Nc2cccc(-c3cnn(C(C)(C)C)c3)c2N1
E3 Binder	CHEMBL4171897	ChEMBL	6.0	—	—	C[C@H](C1CC1)N(Cc1ccccc1)C(=O)CN1C(=O)N[C@]2(CCc3ccccc32)C1=O
E3 Binder	CHEMBL4641354	ChEMBL	8.09	QS1	—	C[C@H](CN[C@@H](C(=O)Nc1ccc(-c2cnn(C)c2)cn1)c1ccccc1)c1ccc(C#N)cc1
E3 Binder	CHEMBL4452725	ChEMBL	6.7	—	—	Cc1cc(-c2ccc(/C=C3\C(=O)N(c4ccc(C(=O)O)cc4)N=C3C3CC3)o2)c([N+](=O)[O-])cc1C
E3 Binder	CHEMBL4461759	ChEMBL	6.8	—	—	Cc1cc(-c2ccc(/C=C3\C(=O)N(c4ccc(C(=O)O)cc4)N=C3C3CC3)s2)c(C(F)(F)F)cc1C
E3 Binder	CHEMBL5274024	ChEMBL	7.51	7OW	—	Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O
E3 Binder	CHEMBL4520444	ChEMBL	6.16	—	—	Cc1ccc(N2C(=O)/C(=C/C=C/c3ccco3)C(=O)NC2=S)cc1Cl
E3 Binder	CHEMBL4277102	ChEMBL	6.16	—	—	Cc1ccc(N2C(=O)/C(=C\C=C\c3ccco3)C(=O)NC2=S)cc1Cl
E3 Binder	CHEMBL3926851	ChEMBL	6.66	JW4	—	Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12
E3 Binder	CHEMBL4636484	ChEMBL	6.28	—	—	Cc1nc(C(=O)[C@H](NCCc2ccc(C#N)cc2)c2ccccc2)c2ccc(-c3cnn(C)c3)cn12
E3 Binder	CHEMBL5180576	ChEMBL	6.58	—	—	Cc1noc(C)c1-c1ccc2c(c1)nc(C1CC1c1ccccc1)n2[C@H]1CC[C@H](O)CC1
E3 Binder	CHEMBL3753333	ChEMBL	6.46	2LL	—	Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1
E3 Binder	CHEMBL5279037	ChEMBL	6.3	—	—	Cc1noc(C)c1-c1ccc2nc(CCc3ccccc3)n(CCN(C)C)c2c1
E3 Binder	CHEMBL4095153	ChEMBL	7.92	—	—	Cn1cc(-c2cc3c(cc2C(F)F)N(c2cc(N4CCOCC4)c4c(c2)n(C)c(=O)n4C)CCC3)cn1
E3 Binder	CHEMBL4072630	ChEMBL	6.0	—	—	Cn1cc(-c2cc3c(cc2C(F)F)N(c2ccc4c(c2)n(C)c(=O)n4C)CCC3)cn1
E3 Binder	CHEMBL4519167	ChEMBL	7.52	—	—	Cn1cc(-c2cc3c(cn2)[C@]2(CC3)NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1
E3 Binder	CHEMBL4636245	ChEMBL	6.92	—	—	Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)cc2)cn1
E3 Binder	CHEMBL4636118	ChEMBL	7.72	QSD	—	Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nc2)cn1
E3 Binder	CHEMBL4642909	ChEMBL	6.11	—	—	Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nn2)cn1
E3 Binder	CHEMBL4648100	ChEMBL	6.24	—	—	Cn1cc(-c2ccc3c(C(=O)C(NCCc4ccc(C#N)cc4)c4ccccc4)n[nH]c3c2)cn1
E3 Binder	CHEMBL4633516	ChEMBL	8.6	—	—	Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3c2)cn1
E3 Binder	CHEMBL4640553	ChEMBL	7.44	—	—	Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3n2)cn1
E3 Binder	CHEMBL4648384	ChEMBL	7.77	—	—	Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)cnn3c2)cn1
E3 Binder	CHEMBL4643833	ChEMBL	7.68	—	—	Cn1cc(-c2ccc3c(c2)CCN3C(=O)[C@H](NCCc2ccc(C#N)cc2)c2ccccc2)cn1
E3 Binder	CHEMBL4450724	ChEMBL	8.62	—	—	Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1
E3 Binder	CHEMBL4474109	ChEMBL	8.4	—	—	Cn1cc(-c2ccc3c(c2)CC[C@@]32OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1
E3 Binder	CHEMBL4587968	ChEMBL	8.74	—	—	Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1
E3 Binder	CHEMBL4567310	ChEMBL	8.89	—	—	Cn1cc(-c2ccc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)cn1
E3 Binder	CHEMBL4441280	ChEMBL	7.85	—	—	Cn1cc(-c2ccc3c(n2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1
E3 Binder	CHEMBL4639768	ChEMBL	7.01	—	—	Cn1cc(-c2ccn3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)cnc3c2)cn1
E3 Binder	CHEMBL4639561	ChEMBL	6.34	—	—	Cn1cc(-c2cnc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)cn2)cn1
E3 Binder	CHEMBL4456527	ChEMBL	8.0	—	—	Cn1cc(-c2cnc3c(c2)CC[C@]32NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)cn1
E3 Binder	CHEMBL4441544	ChEMBL	7.0	—	—	N#Cc1ccc(-c2ccc(/C=C3\SC(=S)N(CCc4ccccc4)C3=O)o2)cc1
E3 Binder	CHEMBL5220732	ChEMBL	9.6	—	—	N#Cc1ccc(C2(C(=O)N3CCC[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC2)cc1
E3 Binder	CHEMBL3774787	ChEMBL	7.96	—	—	N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C(=O)O)c2)NC1=O
E3 Binder	CHEMBL3774491	ChEMBL	7.66	—	—	N=C(N)NCCC[C@@H]1NC(=O)/C(=C/c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)O)C(=O)O)C(=O)O)c2)NC1=O
E3 Binder	CHEMBL4524766	ChEMBL	7.96	—	—	N=C(N)NCCC[C@@H]1NC(=O)/C(=C\c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C(=O)O)c2)NC1=O
E3 Binder	CHEMBL4447371	ChEMBL	7.66	—	—	N=C(N)NCCC[C@@H]1NC(=O)/C(=C\c2ccc(O)c(OCC[C@H](NC(=O)C[C@](O)(CC(=O)O)C(=O)O)C(=O)O)c2)NC1=O
E3 Binder	CHEMBL5219512	ChEMBL	9.2	—	—	O=C(Nc1ccc(O)cc1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5219678	ChEMBL	9.4	—	—	O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5219030	ChEMBL	9.8	—	—	O=C(Nc1ccc2[nH]ccc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5220332	ChEMBL	9.0	—	—	O=C(Nc1ccc2[nH]ncc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5220956	ChEMBL	9.5	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1
E3 Binder	CHEMBL5221053	ChEMBL	10.0	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(Cl)cc2)CCC1
E3 Binder	CHEMBL5219157	ChEMBL	9.9	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2ccc(F)cc2)CCC1
E3 Binder	CHEMBL5219693	ChEMBL	9.8	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5219177	ChEMBL	9.0	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1COCCN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1
E3 Binder	CHEMBL5220994	ChEMBL	10.1	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CC(F)(F)C1
E3 Binder	CHEMBL5219667	ChEMBL	9.7	—	—	O=C(Nc1ccc2[nH]ncc2n1)[C@H]1C[C@@H](F)CN1C(=O)C1(c2ccc(Cl)cc2)CCC1
E3 Binder	CHEMBL5219472	ChEMBL	7.7	—	—	O=C(Nc1ccc2[nH]nnc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL5219204	ChEMBL	7.8	—	—	O=C(Nc1cnc2[nH]ncc2c1)[C@H]1CCCN1C(=O)C1(c2cccc(Cl)c2)CCCC1
E3 Binder	CHEMBL3416536	ChEMBL	6.0	—	—	O=C(O)CCSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O
E3 Binder	CHEMBL1331211	ChEMBL	6.48	—	—	O=C(O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O
E3 Binder	CHEMBL2031566	ChEMBL	6.18	—	—	O=C(O)CSc1cc(NS(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc2c1O
E3 Binder	CHEMBL3421930	ChEMBL	6.96	—	—	O=C1C(Cc2ccccc2)C(=O)N(Cc2ccccc2)C(=O)N1Cc1ccccc1
E3 Binder	CHEMBL5220546	ChEMBL	9.1	—	—	O=C1Cc2cc(NC(=O)[C@H]3CCCN3C(=O)C3(c4cccc(Cl)c4)CCCC3)ccc2N1
E3 Binder	CHEMBL2030281	ChEMBL	6.29	—	—	O=S(=O)(Nc1cc(Sc2ncn[nH]2)c(O)c2ccccc12)c1ccc2ccccc2c1