LG3BP

Details:

UniProt Entry: Q08380
Gene: LGALS3BP
Class: Other E3 Components
Family: Adaptor
Protein length: 585
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q08380
MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV
VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG
VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL
EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ
GYCASLFAIL LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM MLPEELFELQ
FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD
SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL
VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW
KAAIPSALDT NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
16	131	Homologous_superfamily	SRCR-like domain superfamily	IPR036772	G3DSA:3.10.250.10
21	128	Homologous_superfamily	SRCR-like domain superfamily	IPR036772	SSF56487
24	124	Domain	SRCR-like domain	IPR017448	SM00202
24	40	Domain	SRCR domain	IPR001190	PR00258
24	124	Domain	SRCR domain	IPR001190	PS50287
28	124	Domain	SRCR domain	IPR001190	PF00530
29	66	Domain	SRCR domain	IPR001190	PS00420
43	54	Domain	SRCR domain	IPR001190	PR00258
58	68	Domain	SRCR domain	IPR001190	PR00258
89	103	Domain	SRCR domain	IPR001190	PR00258
112	124	Domain	SRCR domain	IPR001190	PR00258
132	253	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
153	221	Domain	BTB/POZ domain	IPR000210	PS50097
260	360	Domain	BTB/Kelch-associated	IPR011705	SM00875
261	358	Domain	BTB/Kelch-associated	IPR011705	PF07707

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007155	cell adhesion	Biological Process	IEA	GO_REF:0000043
GO:0006968	cellular defense response	Biological Process	TAS	PMID:8034587
GO:0007165	signal transduction	Biological Process	TAS	PMID:8390986
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000108
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000002
GO:0005576	extracellular region	Cellular Component	IEA	GO_REF:0000043
GO:0031012	extracellular matrix	Cellular Component	HDA	PMID:20551380
GO:0005615	extracellular space	Cellular Component	IBA	GO_REF:0000033
GO:0031089	platelet dense granule lumen	Cellular Component	TAS	Reactome:R-HSA-481009
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0072562	blood microparticle	Cellular Component	HDA	PMID:22516433
GO:0005044	scavenger receptor activity	Molecular Function	TAS	PMID:8390986
GO:0005515	protein binding	Molecular Function	IPI	PMID:22939624

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.