RING1

Details:

UniProt Entry: Q06587
Gene: RING1
Class: RING
Family: RING4
Protein length: 406
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q06587
MTTPANAQNA SKTWELSLYE LHRTPQEAIM DGTEIAVSPR SLHSELMCPI CLDMLKNTMT
TKECLHRFCS DCIVTALRSG NKECPTCRKK LVSKRSLRPD PNFDALISKI YPSREEYEAH
QDRVLIRLSR LHNQQALSSS IEEGLRMQAM HRAQRVRRPI PGSDQTTTMS GGEGEPGEGE
GDGEDVSSDS APDSAPGPAP KRPRGGGAGG SSVGTGGGGT GGVGGGAGSE DSGDRGGTLG
GGTLGPPSPP GAPSPPEPGG EIELVFRPHP LLVEKGEYCQ TRYVKTTGNA TVDHLSKYLA
LRIALERRQQ QEAGEPGGPG GGASDTGGPD GCGGEGGGAG GGDGPEEPAL PSLEGVSEKQ
YTIYIAPGGG AFTTLNGSLT LELVNEKFWK VSRPLELCYA PTKDPK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	117	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
7	173	Family	E3 ubiquitin-protein ligase RING1/RING2	IPR043540	PTHR46076
47	90	Domain	RING1 , RING finger, HC subclass	IPR042741	cd16739
48	88	Domain	Zinc finger, RING-type	IPR001841	PS50089
48	87	Domain	Zinc finger, RING-type	IPR001841	SM00184
64	73	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
282	400	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0009952	anterior/posterior pattern specification	Biological Process	IEA	GO_REF:0000107
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000120
GO:0048593	camera-type eye morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000120
GO:0006338	chromatin remodeling	Biological Process	IDA	PMID:16943429
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0001739	sex chromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000107
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0031519	PcG protein complex	Cellular Component	IBA	GO_REF:0000033
GO:0035102	PRC1 complex	Cellular Component	IEA	GO_REF:0000120
GO:0003682	chromatin binding	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:15386022
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0097027	ubiquitin-protein transferase activator activity	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾


Q9H4L7	SMRCD	Yes	No	No	No	—	No	E3-specific

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