ZBT16

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
7	158	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
8	123	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
25	124	Domain	BTB/POZ domain	IPR000210	PF00651
34	126	Domain	BTB/POZ domain	IPR000210	SM00225
34	96	Domain	BTB/POZ domain	IPR000210	PS50097
404	426	Domain	Zinc finger C2H2-type	IPR013087	SM00355
404	431	Domain	Zinc finger C2H2-type	IPR013087	PS50157
406	426	Domain	Zinc finger C2H2-type	IPR013087	PS00028
419	470	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
432	459	Domain	Zinc finger C2H2-type	IPR013087	PS50157
432	454	Domain	Zinc finger C2H2-type	IPR013087	SM00355
434	454	Domain	Zinc finger C2H2-type	IPR013087	PS00028
461	488	Domain	Zinc finger C2H2-type	IPR013087	PS50157
461	483	Domain	Zinc finger C2H2-type	IPR013087	SM00355
463	483	Domain	Zinc finger C2H2-type	IPR013087	PS00028
490	512	Domain	Zinc finger C2H2-type	IPR013087	SM00355
490	517	Domain	Zinc finger C2H2-type	IPR013087	PS50157
492	512	Domain	Zinc finger C2H2-type	IPR013087	PS00028
492	512	Domain	Zinc finger C2H2-type	IPR013087	PF00096
499	555	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
518	540	Domain	Zinc finger C2H2-type	IPR013087	SM00355
518	545	Domain	Zinc finger C2H2-type	IPR013087	PS50157
520	540	Domain	Zinc finger C2H2-type	IPR013087	PS00028
546	568	Domain	Zinc finger C2H2-type	IPR013087	PF00096
546	568	Domain	Zinc finger C2H2-type	IPR013087	SM00355
546	573	Domain	Zinc finger C2H2-type	IPR013087	PS50157
548	568	Domain	Zinc finger C2H2-type	IPR013087	PS00028
555	609	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
574	596	Domain	Zinc finger C2H2-type	IPR013087	SM00355
574	596	Domain	Zinc finger C2H2-type	IPR013087	PF00096
574	601	Domain	Zinc finger C2H2-type	IPR013087	PS50157
576	596	Domain	Zinc finger C2H2-type	IPR013087	PS00028
596	648	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
602	629	Domain	Zinc finger C2H2-type	IPR013087	PS50157
602	624	Domain	Zinc finger C2H2-type	IPR013087	SM00355
630	657	Domain	Zinc finger C2H2-type	IPR013087	PS50157
630	652	Domain	Zinc finger C2H2-type	IPR013087	SM00355
632	652	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0008283	cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0001501	skeletal system development	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000107
GO:0008285	negative regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0009880	embryonic pattern specification	Biological Process	IEA	GO_REF:0000107
GO:0009952	anterior/posterior pattern specification	Biological Process	IEA	GO_REF:0000107
GO:0035136	forelimb morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0035137	hindlimb morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0043065	positive regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0048133	male germ-line stem cell asymmetric division	Biological Process	IEA	GO_REF:0000107
GO:0001823	mesonephros development	Biological Process	IEA	GO_REF:0000107
GO:0007417	central nervous system development	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0010557	positive regulation of macromolecule biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0030097	hemopoiesis	Biological Process	IEA	GO_REF:0000107
GO:0034504	protein localization to nucleus	Biological Process	IEA	GO_REF:0000120
GO:0035116	embryonic hindlimb morphogenesis	Biological Process	IEA	GO_REF:0000120
GO:0042733	embryonic digit morphogenesis	Biological Process	IEA	GO_REF:0000120
GO:0043931	ossification involved in bone maturation	Biological Process	IEA	GO_REF:0000120
GO:0045595	regulation of cell differentiation	Biological Process	IEA	GO_REF:0000117
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0051138	positive regulation of NK T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0051240	positive regulation of multicellular organismal process	Biological Process	IEA	GO_REF:0000117
GO:2000026	regulation of multicellular organismal development	Biological Process	IEA	GO_REF:0000117
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:12802276
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:10688654
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	NAS	PMID:9294197
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030099	myeloid cell differentiation	Biological Process	TAS	PMID:9294197
GO:0032332	positive regulation of chondrocyte differentiation	Biological Process	IMP	PMID:21547890
GO:0045600	positive regulation of fat cell differentiation	Biological Process	IMP	PMID:21547890
GO:0045778	positive regulation of ossification	Biological Process	IDA	PMID:21547890
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IDA	PMID:21547890
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000108
GO:0051216	cartilage development	Biological Process	IDA	PMID:21547890
GO:0061036	positive regulation of cartilage development	Biological Process	IDA	PMID:21547890
GO:0001673	male germ cell nucleus	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952630
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000044
GO:0016605	PML body	Cellular Component	IDA	PMID:9294197
GO:0016607	nuclear speck	Cellular Component	IDA	PMID:8541544
GO:0017053	transcription repressor complex	Cellular Component	IDA	PMID:12802276
GO:0032991	protein-containing complex	Cellular Component	IMP	PMID:10980608
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003690	double-stranded DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0019904	protein domain specific binding	Molecular Function	IEA	GO_REF:0000120
GO:0031703	type 2 angiotensin receptor binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001222	transcription corepressor binding	Molecular Function	IPI	PMID:10688654
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:10980608
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:8622986

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

ZBT16

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Enzyme–Substrate Interactions ▾