UBE3A

Details:

UniProt Entry: Q05086

Gene: UBE3A

Class: HECT

Family: HECT1

Protein length: 875

Database confidence: 0.875

InterPro: InterPro Entry

Mode of Action: Complex

AlphaFold Model: Link

PDB Structures: 1c4z, 1d5f, 1eqx, 2kr1, 4giz, 4xr8, 6sjv, 6slm, 6tgk, 6u19

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Start	End	Type	Name	InterPro	Source
3	875	Family	Ubiquitin-protein ligase E3A	IPR017134	PIRSF037201
24	87	Homologous_superfamily	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily	IPR042556	G3DSA:6.10.130.10
30	83	Domain	Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain	IPR032353	PF16558
129	873	Family	Ubiquitin-protein ligase E3A/B/C-like	IPR044611	PTHR45700
521	868	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
523	873	Domain	HECT domain	IPR000569	cd00078
545	875	Domain	HECT domain	IPR000569	SM00119
547	875	Domain	HECT domain	IPR000569	PS50237
577	874	Domain	HECT domain	IPR000569	PF00632

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000120
GO:0010604	positive regulation of macromolecule metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0030518	nuclear receptor-mediated steroid hormone signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0042752	regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000117
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0048513	animal organ development	Biological Process	IEA	GO_REF:0000117
GO:0048731	system development	Biological Process	IEA	GO_REF:0000117
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000104
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0001541	ovarian follicle development	Biological Process	IEA	GO_REF:0000107
GO:0030521	androgen receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:22980980
GO:0035037	sperm entry	Biological Process	IEA	GO_REF:0000107
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0060736	prostate gland growth	Biological Process	IEA	GO_REF:0000107
GO:0150032	positive regulation of protein localization to lysosome	Biological Process	IDA	PMID:28935770
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:22980980
GO:0006508	proteolysis	Biological Process	TAS	PMID:8221889
GO:0007420	brain development	Biological Process	TAS	PMID:8988171
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IDA	PMID:17108031
GO:0032570	response to progesterone	Biological Process	IDA	PMID:16772533
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0048167	regulation of synaptic plasticity	Biological Process	ISS	GO_REF:0000024
GO:0050804	modulation of chemical synaptic transmission	Biological Process	IEA	GO_REF:0000107
GO:0050847	progesterone receptor signaling pathway	Biological Process	IDA	PMID:16772533
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24105792
GO:1904262	negative regulation of TORC1 signaling	Biological Process	ISS	GO_REF:0000024
GO:1905528	positive regulation of Golgi lumen acidification	Biological Process	IEA	GO_REF:0000107
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000104
GO:0000502	proteasome complex	Cellular Component	IEA	GO_REF:0000043
GO:0008021	synaptic vesicle	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099524	postsynaptic cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003713	transcription coactivator activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:12207887
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y5K5	UCHL5	Yes	Yes	Yes	No	29426014, 28514442	EBI-16812280	E3-specific
Q8IXH7	NELFD	Yes	Yes	No	No	21988832	EBI-3940083	E3-specific
Q06830	PRDX1	Yes	Yes	No	No	—	No	E3-specific
Q15257	PTPA	Yes	Yes	No	No	—	No	E3-specific
O43166	SI1L1	Yes	Yes	No	No	—	No	E3-specific
Q9HD26	GOPC	Yes	Yes	No	No	—	No	E3-specific
Q16611	BAK	Yes	Yes	Yes	No	9881696	EBI-8664233	E3-specific
P26045	PTN3	Yes	Yes	No	No	—	No	E3-specific
Q14160	SCRIB	Yes	Yes	No	No	11027293	EBI-7410014	E3-specific
P06733	ENOA	Yes	No	No	No	—	No	E3-specific
Q8WTU0	DDI1	Yes	Yes	No	No	—	No	E3-specific
P33993	MCM7	Yes	Yes	No	No	—	No	E3-specific
P54727	RD23B	Yes	Yes	No	No	29426014	EBI-16807797	E3-specific
P04083	ANXA1	Yes	Yes	No	No	—	No	E3-specific
P54821	PRRX1	Yes	Yes	No	No	—	No	E3-specific
P51451	BLK	Yes	Yes	No	No	—	No	E3-specific
P54725	RD23A	Yes	Yes	No	No	29426014	EBI-16807755	Cluster-specific

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