KCNC4

Details:

UniProt Entry: Q03721
Gene: KCNC4
Class: Other E3 Components
Family: Adaptor
Protein length: 635
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q03721
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT
RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP GVFAYVLNYY RTGKLHCPAD
VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ HRDAEEALDI FESPDGGGSG AGPSDEAGDD
ERELALQRLG PHEGGAGHGA GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI
TTFCLETHEA FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI
VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR FVRILRIFKL
TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY YAERIGARPS DPRGNDHTDF
KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM LVGALCALAG VLTIAMPVPV IVNNFGMYYS
LAMAKQKLPK KRKKHVPRPA QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS
KQNGDANAVL SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA
DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	29	Domain	Potassium channel, voltage dependent, Kv3, inactivation domain	IPR021105	PF11404
18	31	Family	Potassium channel, voltage dependent, Kv3.4	IPR005405	PR01583
33	161	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
36	151	Domain	BTB/POZ domain	IPR000210	SM00225
36	151	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
38	143	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
67	78	Family	Potassium channel, voltage dependent, Kv3.4	IPR005405	PR01583
93	103	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
94	107	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
109	124	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
127	148	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
175	186	Family	Potassium channel, voltage dependent, Kv3.4	IPR005405	PR01583
188	204	Family	Potassium channel, voltage dependent, Kv3.4	IPR005405	PR01583
204	363	Homologous_superfamily	Voltage-dependent channel domain superfamily	IPR027359	G3DSA:1.20.120.350
216	228	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
226	480	Domain	Ion transport domain	IPR005821	PF00520
356	364	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
380	394	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
460	471	Family	Potassium channel, voltage dependent, Kv	IPR003968	PR01491
485	499	Family	Potassium channel, voltage dependent, Kv3	IPR003974	PR01498
510	526	Family	Potassium channel, voltage dependent, Kv3.4	IPR005405	PR01583

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006811	monoatomic ion transport	Biological Process	IEA	GO_REF:0000120
GO:0006813	potassium ion transport	Biological Process	IEA	GO_REF:0000120
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0055085	transmembrane transport	Biological Process	IEA	GO_REF:0000002
GO:0071805	potassium ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0001508	action potential	Biological Process	IBA	GO_REF:0000033
GO:0007268	chemical synaptic transmission	Biological Process	TAS	PMID:1381835
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA	GO_REF:0000002
GO:0034702	monoatomic ion channel complex	Cellular Component	IEA	GO_REF:0000043
GO:0032590	dendrite membrane	Cellular Component	IBA	GO_REF:0000033
GO:0032809	neuronal cell body membrane	Cellular Component	IBA	GO_REF:0000033
GO:0042734	presynaptic membrane	Cellular Component	IBA	GO_REF:0000033
GO:0043679	axon terminus	Cellular Component	IBA	GO_REF:0000033
GO:0045211	postsynaptic membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	TAS	Reactome:R-HSA-1296127
GO:0005216	monoatomic ion channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA	GO_REF:0000002
GO:0005267	potassium channel activity	Molecular Function	IEA	GO_REF:0000043
GO:0022836	gated channel activity	Molecular Function	IEA	GO_REF:0000117
GO:0005251	delayed rectifier potassium channel activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:29507146
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.