MECOM

Details:

UniProt Entry: Q03112
Gene: MECOM
Class: RING
Family: RING10
Protein length: 1230
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 6bw3

Protein Sequence ▾

>Q03112
MRSKGRARKL ATNNECVYGN YPEIPLEEMP DADGVASTPS LNIQEPCSPA TSSEAFTPKE
GSPYKAPIYI PDDIPIPAEF ELRESNMPGA GLGIWTKRKI EVGEKFGPYV GEQRSNLKDP
SYGWEILDEF YNVKFCIDAS QPDVGSWLKY IRFAGCYDQH NLVACQINDQ IFYRVVADIA
PGEELLLFMK SEDYPHETMA PDIHEERQYR CEDCDQLFES KAELADHQKF PCSTPHSAFS
MVEEDFQQKL ESENDLQEIH TIQECKECDQ VFPDLQSLEK HMLSHTEERE YKCDQCPKAF
NWKSNLIRHQ MSHDSGKHYE CENCAKVFTD PSNLQRHIRS QHVGARAHAC PECGKTFATS
SGLKQHKHIH SSVKPFICEV CHKSYTQFSN LCRHKRMHAD CRTQIKCKDC GQMFSTTSSL
NKHRRFCEGK NHFAAGGFFG QGISLPGTPA MDKTSMVNMS HANPGLADYF GANRHPAGLT
FPTAPGFSFS FPGLFPSGLY HRPPLIPASS PVKGLSSTEQ TNKSQSPLMT HPQILPATQD
ILKALSKHPS VGDNKPVELQ PERSSEERPF EKISDQSESS DLDDVSTPSG SDLETTSGSD
LESDIESDKE KFKENGKMFK DKVSPLQNLA SINNKKEYSN HSIFSPSLEE QTAVSGAVND
SIKAIASIAE KYFGSTGLVG LQDKKVGALP YPSMFPLPFF PAFSQSMYPF PDRDLRSLPL
KMEPQSPGEV KKLQKGSSES PFDLTTKRKD EKPLTPVPSK PPVTPATSQD QPLDLSMGSR
SRASGTKLTE PRKNHVFGGK KGSNVESRPA SDGSLQHARP TPFFMDPIYR VEKRKLTDPL
EALKEKYLRP SPGFLFHPQM SAIENMAEKL ESFSALKPEA SELLQSVPSM FNFRAPPNAL
PENLLRKGKE RYTCRYCGKI FPRSANLTRH LRTHTGEQPY RCKYCDRSFS ISSNLQRHVR
NIHNKEKPFK CHLCDRCFGQ QTNLDRHLKK HENGNMSGTA TSSPHSELES TGAILDDKED
AYFTEIRNFI GNSNHGSQSP RNVEERMNGS HFKDEKALVT SQNSDLLDDE EVEDEVLLDE
EDEDNDITGK TGKEPVTSNL HEGNPEDDYE ETSALEMSCK TSPVRYKEEE YKSGLSALDH
IRHFTDSLKM RKMEDNQYSE AELSSFSTSH VPEELKQPLH RKSKSQAYAM MLSLSDKESL
HSTSHSSSNV WHSMARAAAE SSAIQSISHV

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
43	193	Homologous_superfamily	SET domain superfamily	IPR046341	G3DSA:2.170.270.10
47	204	Domain	PRDM3, PR/SET domain	IPR044411	cd19214
78	196	Domain	SET domain	IPR001214	SM00317
78	190	Domain	SET domain	IPR001214	PS50280
79	186	Homologous_superfamily	SET domain superfamily	IPR046341	SSF82199
209	229	Domain	Zinc finger C2H2-type	IPR013087	SM00355
209	237	Domain	Zinc finger C2H2-type	IPR013087	PS50157
263	285	Domain	Zinc finger C2H2-type	IPR013087	SM00355
263	290	Domain	Zinc finger C2H2-type	IPR013087	PS50157
264	313	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
265	285	Domain	Zinc finger C2H2-type	IPR013087	PS00028
291	313	Domain	Zinc finger C2H2-type	IPR013087	PF00096
291	313	Domain	Zinc finger C2H2-type	IPR013087	SM00355
291	318	Domain	Zinc finger C2H2-type	IPR013087	PS50157
293	313	Domain	Zinc finger C2H2-type	IPR013087	PS00028
299	357	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
319	342	Domain	Zinc finger C2H2-type	IPR013087	SM00355
319	347	Domain	Zinc finger C2H2-type	IPR013087	PS50157
319	342	Domain	Zinc finger C2H2-type	IPR013087	PF00096
321	342	Domain	Zinc finger C2H2-type	IPR013087	PS00028
342	394	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
348	370	Domain	Zinc finger C2H2-type	IPR013087	PF00096
348	375	Domain	Zinc finger C2H2-type	IPR013087	PS50157
348	370	Domain	Zinc finger C2H2-type	IPR013087	SM00355
350	370	Domain	Zinc finger C2H2-type	IPR013087	PS00028
376	403	Domain	Zinc finger C2H2-type	IPR013087	PS50157
376	398	Domain	Zinc finger C2H2-type	IPR013087	SM00355
376	398	Domain	Zinc finger C2H2-type	IPR013087	PF00096
378	398	Domain	Zinc finger C2H2-type	IPR013087	PS00028
405	432	Domain	Zinc finger C2H2-type	IPR013087	SM00355
405	432	Domain	Zinc finger C2H2-type	IPR013087	PS50157
406	425	Domain	Zinc finger C2H2-type	IPR013087	PF00096
908	958	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
912	934	Domain	Zinc finger C2H2-type	IPR013087	SM00355
912	934	Domain	Zinc finger C2H2-type	IPR013087	PF00096
912	939	Domain	Zinc finger C2H2-type	IPR013087	PS50157
914	934	Domain	Zinc finger C2H2-type	IPR013087	PS00028
940	968	Domain	Zinc finger C2H2-type	IPR013087	PS50157
940	963	Domain	Zinc finger C2H2-type	IPR013087	PF00096
940	963	Domain	Zinc finger C2H2-type	IPR013087	SM00355
942	963	Domain	Zinc finger C2H2-type	IPR013087	PS00028
948	993	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
969	991	Domain	Zinc finger C2H2-type	IPR013087	SM00355
969	996	Domain	Zinc finger C2H2-type	IPR013087	PS50157
969	991	Domain	Zinc finger C2H2-type	IPR013087	PF00096
971	991	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000120
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0032259	methylation	Biological Process	IEA	GO_REF:0000043
GO:0043069	negative regulation of programmed cell death	Biological Process	IMP	PMID:10856240
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000108
GO:0046329	negative regulation of JNK cascade	Biological Process	IMP	PMID:10856240
GO:0051726	regulation of cell cycle	Biological Process	IDA	PMID:11568182
GO:0070828	heterochromatin organization	Biological Process	ISS	GO_REF:0000024
GO:0071425	hematopoietic stem cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0000118	histone deacetylase complex	Cellular Component	IDA	PMID:11568182
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5634802
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:10856240
GO:0008168	methyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046974	histone H3K9 methyltransferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0140938	histone H3 methyltransferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0140947	histone H3K9me2 methyltransferase activity	Molecular Function	IEA	GO_REF:0000116
GO:0140948	histone H3K9 monomethyltransferase activity	Molecular Function	IEA	GO_REF:0000003
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:15897867

Enzyme–Substrate Interactions ▾

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