RNF4

Details:

UniProt Entry: P78317
Gene: RNF4
Class: RING
Family: RING4
Protein length: 190
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 2ea6, 2xeu, 4ppe

Protein Sequence ▾

>P78317
MSTRKRRGGA INSRQAQKRT REATSTPEIS LEAEPIELVE TAGDEIVDLT CESLEPVVVD
LTHNDSVVIV DERRRPRRNA RRLPQDHADS CVVSSDDEEL SRDRDVYVTT HTPRNARDEG
ATGLRPSGTV SCPICMDGYS EIVQNGRLIV STECGHVFCS QCLRDSLKNA NTCPTCRKKI
NHKRYHPIYI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
127	180	Domain	RNF4, RING finger, HC subclass	IPR043295	cd16533
128	190	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
132	176	Domain	Zinc finger, RING-type	IPR001841	SM00184
132	177	Domain	Zinc finger, RING-type	IPR001841	PS50089
154	163	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000117
GO:0006974	DNA damage response	Biological Process	IDA	PMID:35013556
GO:0120186	negative regulation of protein localization to chromatin	Biological Process	IDA	PMID:35013556
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	ISS	GO_REF:0000024
GO:0046685	response to arsenic-containing substance	Biological Process	IDA	PMID:20943951
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070534	protein K63-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070936	protein K48-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0070979	protein K11-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0085020	protein K6-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0090169	regulation of spindle assembly	Biological Process	IMP	PMID:20212317
GO:0090234	regulation of kinetochore assembly	Biological Process	IMP	PMID:20212317
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:1990752	microtubule end	Cellular Component	IDA	GO_REF:0000052
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:10713105
GO:0031491	nucleosome binding	Molecular Function	ISS	GO_REF:0000024
GO:0032184	SUMO polymer binding	Molecular Function	IDA	PMID:35013556
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:24714598
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q8N907	DAND5	Yes	Yes	No	No	—	No	E3-specific
Q92674	CENPI	Yes	Yes	No	No	—	No	E3-specific
Q99814	EPAS1	Yes	Yes	No	No	—	No	E3-specific
P78317	RNF4	Yes	Yes	Yes	Yes	24714598	EBI-9979319	E3-specific
P08047	SP1	Yes	No	No	No	—	No	E3-specific

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Handle	—	PROTACpedia, PROTACDB3	6.0*	—	—	COc1ccc(Oc2ccc(N(Cc3ccccc3)C(=O)CCl)cc2)cc1

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