SKP1

Details:

UniProt Entry: P63208
Gene: SKP1
Class: Other E3 Components
Family: Adaptor
Protein length: 163
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P63208
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ
WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC
KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	163	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
1	163	Family	S-phase kinase-associated protein 1	IPR016897	PIRSF028729
1	112	Family	S-phase kinase-associated protein 1-like	IPR001232	SM00512
2	67	Domain	SKP1 component, POZ domain	IPR016073	PF03931
3	70	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
4	159	Family	S-phase kinase-associated protein 1	IPR016897	PTHR11165
85	160	Homologous_superfamily	SKP1-like, dimerisation domain superfamily	IPR036296	SSF81382
113	160	Domain	SKP1 component, dimerisation	IPR016072	PF01466

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IDA	PMID:34480022
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34480022
GO:0061564	axon development	Biological Process	ISS	PMID:30304512
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:1904037	positive regulation of epithelial cell apoptotic process	Biological Process	IDA	PMID:34480022
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:12820959
GO:0006338	chromatin remodeling	Biological Process	IDA	PMID:16943429
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051457	maintenance of protein location in nucleus	Biological Process	IPI	PMID:21378169
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000104
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-1363328
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000107
GO:0031467	Cul7-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0031519	PcG protein complex	Cellular Component	IDA	PMID:16943429
GO:0005515	protein binding	Molecular Function	IPI	PMID:11238952
GO:0008013	beta-catenin binding	Molecular Function	IDA	PMID:12820959
GO:0019904	protein domain specific binding	Molecular Function	IPI	PMID:15996101
GO:0097602	cullin family protein binding	Molecular Function	IBA	GO_REF:0000033
GO:0140677	molecular function activator activity	Molecular Function	IDA	PMID:29997255
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:15145941
GO:1990444	F-box domain binding	Molecular Function	IPI	PMID:12820959
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:12820959
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IDA	PMID:12820959

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