SKP1

Details:

UniProt Entry: P63208
Gene: SKP1
Class: Other E3 Components
Family: Adaptor
Protein length: 163
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P63208
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ
WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC
KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	163	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
1	163	Family	S-phase kinase-associated protein 1	IPR016897	PIRSF028729
1	112	Family	S-phase kinase-associated protein 1-like	IPR001232	SM00512
2	67	Domain	SKP1 component, POZ domain	IPR016073	PF03931
3	70	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
4	159	Family	S-phase kinase-associated protein 1	IPR016897	PTHR11165
85	160	Homologous_superfamily	SKP1-like, dimerisation domain superfamily	IPR036296	SSF81382
113	160	Domain	SKP1 component, dimerisation	IPR016072	PF01466

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IDA	PMID:34480022
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34480022
GO:0061564	axon development	Biological Process	ISS	PMID:30304512
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:1904037	positive regulation of epithelial cell apoptotic process	Biological Process	IDA	PMID:34480022
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:12820959
GO:0006338	chromatin remodeling	Biological Process	IDA	PMID:16943429
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051457	maintenance of protein location in nucleus	Biological Process	IPI	PMID:21378169
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000104
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-1363328
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000107
GO:0031467	Cul7-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0031519	PcG protein complex	Cellular Component	IDA	PMID:16943429
GO:0005515	protein binding	Molecular Function	IPI	PMID:11238952
GO:0008013	beta-catenin binding	Molecular Function	IDA	PMID:12820959
GO:0019904	protein domain specific binding	Molecular Function	IPI	PMID:15996101
GO:0097602	cullin family protein binding	Molecular Function	IBA	GO_REF:0000033
GO:0140677	molecular function activator activity	Molecular Function	IDA	PMID:29997255
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:15145941
GO:1990444	F-box domain binding	Molecular Function	IPI	PMID:12820959
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:12820959
GO:1990757	ubiquitin ligase activator activity	Molecular Function	IDA	PMID:12820959

Data Usage Statement and License Agreement

Ownership and Copyright

The E3 Ligome database, including all associated data, metadata, and documentation, is the intellectual property of Goethe University (PROXIDRUGs consortium) under the InnoDATA project.
The contents of this Database are protected under applicable copyright and database protection laws.

Prohibited Use

Use of the Database or any derivative works for commercial purposes without prior written consent from Dr. Ramachandra M. Bhaskara (Goethe University, Frankfurt and the PROXIDRUGs consortia).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Commercial purpose

The sale, lease, license, or other transfer of DATA or MODIFICATIONS to a for-profit organization. COMMERCIAL PURPOSES shall also include uses of DATA or MODIFICATIONS by any other organization, including RECIPIENT, to perform contract research to screen E3–substrate networks and compound libraries, to manufacture products for general sale or to conduct research activities that result in any sale, lease, license, or transfer of DATA or MODIFICATIONS for-profit organization.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Licensing

Unless otherwise stated, the Human E3 Ligome Database and all associated data are licensed under the Creative Commons Attribution 4.0 International License ( CC BY-NC-SA 4.0).
Contributors must agree to license their contributions under the same CC BY-NC-SA 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta, A., Cristiani, A., Nikte, S.V. et al. Multi-scale classification decodes the complexity of the human E3 ligome. Nat Commun 16, 11382 (2025).

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.