UBE2K

Details:

UniProt Entry: P61086
Gene: UBE2K
Class: Other E3 Components
Family: E2
Protein length: 200
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P61086
MANIAVQRIK REFKEVLKSE ETSKNQIKVD LVDENFTELR GEIAGPPDTP YEGGRYQLEI
KIPETYPFNP PKVRFITKIW HPNISSVTGA ICLDILKDQW AAAMTLRTVL LSLQALLAAA
EPDDPQDAVV ANQYKQNPEM FKQTARLWAH VYAGAPVSSP EYTKKIENLC AMGFDRNAVI
VALSSKSWDV ETATELLLSN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	157	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
2	158	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
4	154	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
6	149	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
8	147	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
80	96	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183
157	198	Homologous_superfamily	UBA-like superfamily	IPR009060	SSF46934
160	200	Domain	Ubiquitin-associated domain	IPR015940	PS50030
162	199	Domain	Ubiquitin-associated domain	IPR015940	SM00165
162	197	Domain	Ubiquitin-associated domain	IPR015940	PF00627
163	200	Domain	Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain	IPR042599	cd14390

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:23386060
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Biological Process	IDA	PMID:24882218
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:24882218
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:8702625
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Biological Process	IDA	PMID:24882218
GO:0010994	free ubiquitin chain polymerization	Biological Process	IDA	PMID:24882218
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035458	cellular response to interferon-beta	Biological Process	IMP	PMID:24882218
GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	Biological Process	IMP	PMID:26707646
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IC	PMID:24882218
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8852129
GO:0032433	filopodium tip	Cellular Component	IEA	GO_REF:0000107
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:17500595
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:16714285
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	IDA	PMID:17873885
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000003

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