UBC12

Details:

UniProt Entry: P61081
Gene: UBE2M
Class: Other E3 Components
Family: E2
Protein length: 183
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P61081
MIKLFSLKQQ KKEEESAGGT KGSSKKASAA QLRIQKDINE LNLPKTCDIS FSDPDDLLNF
KLVICPDEGF YKSGKFVFSF KVGQGYPHDP PKVKCETMVY HPNIDLEGNV CLNILREDWK
PVLTINSIIY GLQYLFLEPN PEDPLNKEAA EVLQNNRRLF EQNVQRSMRG GYIGSTYFER
CLK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
10	180	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
24	183	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
29	173	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
33	167	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
33	166	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
100	115	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032446	protein modification by small protein conjugation	Biological Process	IEA	GO_REF:0000117
GO:0150052	regulation of postsynapse assembly	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0036211	protein modification process	Biological Process	IMP	PMID:15694336
GO:0043687	post-translational protein modification	Biological Process	TAS	Reactome:R-HSA-597592
GO:0045116	protein neddylation	Biological Process	IBA	GO_REF:0000033
GO:0098793	presynapse	Cellular Component	IEA	GO_REF:0000107
GO:0098794	postsynapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-8952638
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:15361859
GO:0019788	NEDD8 transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0061654	NEDD8 conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000003

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