FBXW4

Details:

UniProt Entry: P57775
Gene: FBXW4
Class: Other E3 Components
Family: Receptor
Protein length: 412
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P57775
MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR
FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ
MPWMQLEDDS LYISQANFIL AYQFRPDGAS LNRRPLGVFA GHDEDVCHFV LANSHIVSAG
GDGKIGIHKI HSTFTVKYSA HEQEVNCVDC KGGIIVSGSR DRTAKVWPLA SGRLGQCLHT
IQTEDRVWSI AISPLLSSFV TGTACCGHFS PLRIWDLNSG QLMTHLGSDF PPGAGVLDVM
YESPFTLLSC GYDTYVRYWD LRTSVRKCVM EWEEPHDSTL YCLQTDGNHL LATGSSYYGV
VRLWDRRQRA CLHAFPLTST PLSSPVYCLR LTTKHLYAAL SYNLHVLDFQ NP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
24	77	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
25	71	Domain	F-box domain	IPR001810	PS50181
29	72	Domain	F-box domain	IPR001810	PF12937
133	265	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
152	189	Repeat	WD40 repeat	IPR001680	SM00320
153	399	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
191	228	Repeat	WD40 repeat	IPR001680	SM00320
197	227	Repeat	WD40 repeat	IPR001680	PF00400
198	233	Repeat	WD40 repeat	IPR001680	PS50082
234	276	Repeat	WD40 repeat	IPR001680	SM00320
266	412	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
283	320	Repeat	WD40 repeat	IPR001680	SM00320
325	365	Repeat	WD40 repeat	IPR001680	SM00320
328	365	Repeat	WD40 repeat	IPR001680	PF00400

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0042733	embryonic digit morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0051216	cartilage development	Biological Process	IEA	GO_REF:0000107
GO:0060173	limb development	Biological Process	IEA	GO_REF:0000107
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	NAS	PMID:10945468
GO:0030326	embryonic limb morphogenesis	Biological Process	NAS	PMID:10405324
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10945468
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:22632967

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