COPA

Details:

UniProt Entry: P53621
Gene: COPA
Class: Other E3 Components
Family: Adaptor
Protein length: 1224
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P53621
MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW
NWQSRTCVCV LTGHNHYVMC AQFHPTEDLV VSASLDQTVR VWDISGLRKK NLSPGAVESD
VRGITGVDLF GTTDAVVKHV LEGHDRGVNW AAFHPTMPLI VSGADDRQVK IWRMNESKAW
EVDTCRGHYN NVSCAVFHPR QELILSNSED KSIRVWDMSK RTGVQTFRRD HDRFWVLAAH
PNLNLFAAGH DGGMIVFKLE RERPAYAVHG NMLHYVKDRF LRQLDFNSSK DVAVMQLRSG
SKFPVFNMSY NPAENAVLLC TRASNLENST YDLYTIPKDA DSQNPDAPEG KRSSGLTAVW
VARNRFAVLD RMHSLLIKNL KNEITKKVQV PNCDEIFYAG TGNLLLRDAD SITLFDVQQK
RTLASVKISK VKYVIWSADM SHVALLAKHA IVICNRKLDA LCNIHENIRV KSGAWDESGV
FIYTTSNHIK YAVTTGDHGI IRTLDLPIYV TRVKGNNVYC LDRECRPRVL TIDPTEFKFK
LALINRKYDE VLHMVRNAKL VGQSIIAYLQ KKGYPEVALH FVKDEKTRFS LALECGNIEI
ALEAAKALDD KNCWEKLGEV ALLQGNHQIV EMCYQRTKNF DKLSFLYLIT GNLEKLRKMM
KIAEIRKDMS GHYQNALYLG DVSERVRILK NCGQKSLAYL TAATHGLDEE AESLKETFDP
EKETIPDIDP NAKLLQPPAP IMPLDTNWPL LTVSKGFFEG TIASKGKGGA LAADIDIDTV
GTEGWGEDAE LQLDEDGFVE ATEGLGDDAL GKGQEEGGGW DVEEDLELPP ELDISPGAAG
GAEDGFFVPP TKGTSPTQIW CNNSQLPVDH ILAGSFETAM RLLHDQVGVI QFGPYKQLFL
QTYARGRTTY QALPCLPSMY GYPNRNWKDA GLKNGVPAVG LKLNDLIQRL QLCYQLTTVG
KFEEAVEKFR SILLSVPLLV VDNKQEIAEA QQLITICREY IVGLSVETER KKLPKETLEQ
QKRICEMAAY FTHSNLQPVH MILVLRTALN LFFKLKNFKT AATFARRLLE LGPKPEVAQQ
TRKILSACEK NPTDAYQLNY DMHNPFDICA ASYRPIYRGK PVEKCPLSGA CYSPEFKGQI
CRVTTVTEIG KDVIGLRISP LQFR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	1220	Family	Coatomer subunit alpha	IPR016391	PIRSF003354
1	320	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
2	37	Repeat	WD40 repeat	IPR001680	SM00320
5	316	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
5	39	Repeat	WD40 repeat	IPR001680	PS50082
40	79	Repeat	WD40 repeat	IPR001680	SM00320
45	79	Repeat	WD40 repeat	IPR001680	PF00400
47	88	Repeat	WD40 repeat	IPR001680	PS50082
82	121	Repeat	WD40 repeat	IPR001680	SM00320
84	121	Repeat	WD40 repeat	IPR001680	PF00400
89	130	Repeat	WD40 repeat	IPR001680	PS50082
108	122	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
124	163	Repeat	WD40 repeat	IPR001680	SM00320
126	163	Repeat	WD40 repeat	IPR001680	PF00400
131	165	Repeat	WD40 repeat	IPR001680	PS50082
150	164	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
150	164	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
194	233	Repeat	WD40 repeat	IPR001680	SM00320
201	242	Repeat	WD40 repeat	IPR001680	PS50082
212	291	Domain	Anaphase-promoting complex subunit 4, WD40 domain	IPR024977	PF12894
238	645	Homologous_superfamily	Cytochrome cd1-nitrite reductase-like, haem d1 domain superfamily	IPR011048	SSF51004
238	277	Repeat	WD40 repeat	IPR001680	SM00320
245	286	Repeat	WD40 repeat	IPR001680	PS50082
264	278	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
280	318	Repeat	WD40 repeat	IPR001680	SM00320
343	766	Domain	Coatomer, WD associated region	IPR006692	PF04053
815	1224	Domain	Coatomer, alpha subunit, C-terminal	IPR010714	PF06957

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006886	intracellular protein transport	Biological Process	IEA	GO_REF:0000120
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Biological Process	IEA	GO_REF:0000002
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000120
GO:0030157	pancreatic juice secretion	Biological Process	IDA	PMID:1429581
GO:0099612	protein localization to axon	Biological Process	IEA	GO_REF:0000107
GO:1902463	protein localization to cell leading edge	Biological Process	IEA	GO_REF:0000107
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	Biological Process	IBA	GO_REF:0000033
GO:0006891	intra-Golgi vesicle-mediated transport	Biological Process	IBA	GO_REF:0000033
GO:0007165	signal transduction	Biological Process	IEA	GO_REF:0000108
GO:0030663	COPI-coated vesicle membrane	Cellular Component	IEA	GO_REF:0000044
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030137	COPI-coated vesicle	Cellular Component	IEA	GO_REF:0000117
GO:0030426	growth cone	Cellular Component	IEA	GO_REF:0000117
GO:0030117	membrane coat	Cellular Component	IEA	GO_REF:0000002
GO:0030126	COPI vesicle coat	Cellular Component	IEA	GO_REF:0000120
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0005576	extracellular region	Cellular Component	IEA	GO_REF:0000120
GO:0005615	extracellular space	Cellular Component	IDA	PMID:1429581
GO:0005789	endoplasmic reticulum membrane	Cellular Component	TAS	Reactome:R-HSA-6811423
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-6807872
GO:0030133	transport vesicle	Cellular Component	TAS	Reactome:R-HSA-6807877
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19199708
GO:0005198	structural molecule activity	Molecular Function	IEA	GO_REF:0000002
GO:0003729	mRNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0005179	hormone activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16169070

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