ZN131

Details:

UniProt Entry: P52739
Gene: ZNF131
Class: RING
Family: RING6
Protein length: 623
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>P52739
MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA VLAACSKFFY
KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE EANDVWKAAE FLQMLEAIKA
LEVRNKENSA PLEENTTGKN EAKKRKIAET SNVITESLPS AESEPVEIEV EIAEGTIEVE
DEGIETLEEV ASAKQSVKYI QSTGSSDDSA LALLADITSK YRQGDRKGQI KEDGCPSDPT
SKQVEGIEIV ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE
SAWKQHLNCY HLEEGGVSKK QRTGKKIHVC QYCEKQFDHF GHFKEHLRKH TGEKPFECPN
CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV FNSWDQFKDH LVIHTGDKPN
HCTLCDLWFM QGNELRRHLS DAHNISERLV TEEVLSVETR VQTEPVTSMT IIEQVGKVHV
LPLLQVQVDS AQVTVEQVHP DLLQDSQVHD SHMSELPEQV QVSYLEVGRI QTEEGTEVHV
EELHVERVNQ MPVEVQTELL EADLDHVTPE IMNQEERESS QADAAEAARE DHEDAEDLET
KPTVDSEAEK AENEDRTALP VLE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	162	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
12	121	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	126	Domain	BTB/POZ domain	IPR000210	PF00651
34	129	Domain	BTB/POZ domain	IPR000210	SM00225
34	98	Domain	BTB/POZ domain	IPR000210	PS50097
259	298	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
261	283	Domain	Zinc finger C2H2-type	IPR013087	SM00355
261	288	Domain	Zinc finger C2H2-type	IPR013087	PS50157
263	283	Domain	Zinc finger C2H2-type	IPR013087	PS00028
288	311	Domain	Zinc finger C2H2-type	IPR013087	SM00355
288	316	Domain	Zinc finger C2H2-type	IPR013087	PS50157
290	311	Domain	Zinc finger C2H2-type	IPR013087	PS00028
323	374	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
328	350	Domain	Zinc finger C2H2-type	IPR013087	SM00355
328	355	Domain	Zinc finger C2H2-type	IPR013087	PS50157
330	350	Domain	Zinc finger C2H2-type	IPR013087	PS00028
356	386	Domain	Zinc finger C2H2-type	IPR013087	PS50157
356	376	Domain	Zinc finger C2H2-type	IPR013087	SM00355
389	438	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
392	419	Domain	Zinc finger C2H2-type	IPR013087	PS50157
392	414	Domain	Zinc finger C2H2-type	IPR013087	SM00355
394	414	Domain	Zinc finger C2H2-type	IPR013087	PS00028
420	443	Domain	Zinc finger C2H2-type	IPR013087	SM00355
422	443	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0045111	intermediate filament cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:31515488
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾

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