UB2E1

Details:

UniProt Entry: P51965
Gene: UBE2E1
Class: Other E3 Components
Family: E2
Protein length: 193
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>P51965
MSDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT
LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY
HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH
DRMARQWTKR YAT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
31	192	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
38	193	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
47	193	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
50	188	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
51	187	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
120	135	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0070936	protein K48-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0010629	negative regulation of gene expression	Biological Process	IDA	PMID:39096901
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:8576257
GO:0032020	ISG15-protein conjugation	Biological Process	IBA	GO_REF:0000033
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:16307923
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-174057
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1169402
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:16307923
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16307923
GO:0042296	ISG15 transferase activity	Molecular Function	IBA	GO_REF:0000033

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